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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
PR:000035427 -
http://purl.obolibrary.org/obo/PR_000035427
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000035427
PRO name
mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
Synonyms
PRO-Short-label
:
EXACT:
BUB1B/Phos:CDK1+PLK1
Other
:
RELATED:
BUBR1 phosphorylated
Definition
"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated at one or more CDK1 and PLK1 consensus sites. The phosphorylation at CDK1 site(s) is necessary for the phosphorylation at the PLK1 site(s) to occur. Example:
UniProtKB:O60566
, Thr-620,
MOD:00047
|(Ser-676,
MOD:00046
and/or Thr-680,
MOD:00047
)|(Thr-792,
MOD:00047
and/or Thr-1008,
MOD:00047
)." [
PMID:10593653
,
PMID:11030144
,
PMID:11792804
,
PMID:17276342
,
PMID:17376779
,
PMID:17785528
,
PMID:18440313
, PRO:KER]
PRO Category
modification
Parent
PR:000004855
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
PR:000037070
phosphoprotein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000035427
mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
BUB1B/Phos:CDK1+PLK1
organism-modification
PR:000035428
mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
hBUB1B/Phos:2
Yes
Yes
organism-modification
PR:000035430
mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog)
frog-BUB1B/Phos:2
Yes
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BUB1B/Phos:CDK1+PLK1
forms found in complexes
BUB1B/Phos:CDK1+PLK1
Component
Complexes
PR:000035428
hBUB1B/Phos:2
PR:000035577
BUB1:phosphoBUB1B complex (human)
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006974
DNA damage response
PR:000035428
hBUB1B/Phos:2
PMID:18440313
increased
GO:0008608
attachment of spindle microtubules to kinetochore
PR:000035428
hBUB1B/Phos:2
PMID:17785528
increased
GO:0051310
metaphase chromosome alignment
PR:000035428
hBUB1B/Phos:2
PMID:17376779
;
PMID:17785528
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004672
protein kinase activity
PR:000035428
hBUB1B/Phos:2
PMID:17376779
PR:000035430
frog-BUB1B/Phos:2
PMID:17998400
GO:0005515
protein binding
PR:000035428
hBUB1B/Phos:2
PMID:23079597
PR:000035428
hBUB1B/Phos:2
PMID:23079597
PR:000035428
hBUB1B/Phos:2
PMID:23079597
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0000776
kinetochore
PR:000035428
hBUB1B/Phos:2
PMID:17785528
