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Protein Ontology report - mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
PR:000035427 - http://purl.obolibrary.org/obo/PR_000035427
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000035427   
  PRO namemitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form 
  Synonyms
PRO-Short-label: EXACT:BUB1B/Phos:CDK1+PLK1
Other: RELATED:BUBR1 phosphorylated
  Definition"A mitotic checkpoint serine/threonine-protein kinase BUB1 beta that has been phosphorylated at one or more CDK1 and PLK1 consensus sites. The phosphorylation at CDK1 site(s) is necessary for the phosphorylation at the PLK1 site(s) to occur. Example: UniProtKB:O60566, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)." [PMID:10593653, PMID:11030144, PMID:11792804, PMID:17276342, PMID:17376779, PMID:17785528, PMID:18440313, PRO:KER] 
  PRO Categorymodification 
  ParentPR:000004855 mitotic checkpoint serine/threonine-protein kinase BUB1 beta
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000035427 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form
BUB1B/Phos:CDK1+PLK1

organism-modification


PR:000035428 mitotic checkpoint serine/threonine-protein kinase BUB1 beta phosphorylated 2 (human)
hBUB1B/Phos:2
Yes
Yes
organism-modification


PR:000035430 mitotic checkpoint serine/threonine-protein kinase BUB1 beta CDK1- and PLK1-phosphorylated form (frog)
frog-BUB1B/Phos:2
Yes
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BUB1B/Phos:CDK1+PLK1 forms found in complexes   

BUB1B/Phos:CDK1+PLK1 Component
 Complexes
PR:000035428 hBUB1B/Phos:2 PR:000035577 BUB1:phosphoBUB1B complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035428 hBUB1B/Phos:2
Example: UniProtKB:O60566-1, Thr-620, MOD:00047|(Ser-676, MOD:00046 and/or Thr-680, MOD:00047)|(Thr-792, MOD:00047 and/or Thr-1008, MOD:00047)		 acts_upstream_of_or_withinGO:0006974 DNA damage response PMID:18440313
increased GO:0008608 attachment of spindle microtubules to kinetochore relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17785528
increased GO:0051310 metaphase chromosome alignment relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779; PMID:17785528
enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17376779
increased GO:0005515 protein binding with PR:O43683 BUB1 PMID:23079597
increased GO:0005515 protein binding with PR:Q15172 hPPP2R5A PMID:23079597
increased GO:0005515 protein binding relative to PR:000035425 frog-BUB1B/PhosRes- PMID:23079597
located_inGO:0000776 kinetochore PMID:17785528
PR:000035430 frog-BUB1B/Phos:2
UniProtKB:Q8JGT8, Thr-605, MOD:00047|MOD:00696		 enablesincreased GO:0004672 protein kinase activity relative to PR:000035425 frog-BUB1B/PhosRes- PMID:17998400