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Protein Ontology report - ribosomal protein S6 kinase alpha
PR:000029187 - http://purl.obolibrary.org/obo/PR_000029187
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000029187   
  PRO nameribosomal protein S6 kinase alpha 
  Synonyms
Other: EXACT:MAPK-activated protein kinase-1 | MAPKAP-K1 | p90 ribosomal S6 kinase | p90RSK | ribosomal protein S6 kinase II
  Definition"A protein that has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069) followed by a Protein kinase C terminal domain (Pfam:PF00433) and another copy of the a Protein kinase domain (Pfam:PF00069). Prototype members of this class act downstream of ERK1/2 signaling pahtway. There are two functional kinase domains that are activated in a sequential manner by a series of phosphorylations." [PMID:10411321, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 17                                        
         Sequence2                                                  Organism-Sequence 23                                        
         Modification0                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000606
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000029187

ribosomal protein S6 kinase alpha

Firm-sspA/SigPep-


"A protein that has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069) followed by a Protein kinase C terminal domain (Pfam:PF00433) and another copy of the a Protein kinase domain (Pfam:PF00069). Prototype members of this class act downstream of ERK1/2 signaling pahtway. There are two functional kinase domains that are activated in a sequential manner by a series of phosphorylations." [PMID:10411321, PRO:CNA]

Yes

gene



PR:000014282

ribosomal protein S6 kinase alpha-1

RPS6KA1


"A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P18652

ribosomal protein S6 kinase 2 alpha (chicken)

chick-RPS6KA1


"A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of chicken." [OMA:P18652, PRO:DNx]


organism-gene



PR:P18653

ribosomal protein S6 kinase alpha-1 (mouse)

mRPS6KA1


"A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of mouse." [OMA:P18653, PRO:DNx]


organism-gene



PR:Q15418

ribosomal protein S6 kinase alpha-1 (human)

hRPS6KA1


"A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15418]


organism-sequence



PR:Q15418-1

ribosomal protein S6 kinase alpha-1 isoform h1 (human)

hRPS6KA1/iso:h1


"A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-1." [PRO:DNx, UniProtKB:Q15418]


organism-sequence



PR:Q15418-2

ribosomal protein S6 kinase alpha-1 isoform h2 (human)

hRPS6KA1/iso:h2


"A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-2." [PRO:DNx, UniProtKB:Q15418]


organism-sequence



PR:Q15418-3

ribosomal protein S6 kinase alpha-1 isoform h3 (human)

hRPS6KA1/iso:h3


"A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-3." [PRO:DNx, UniProtKB:Q15418]


organism-sequence



PR:Q15418-4

ribosomal protein S6 kinase alpha-1 isoform h4 (human)

hRPS6KA1/iso:h4


"A ribosomal protein S6 kinase alpha-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15418-4." [PRO:DNx, UniProtKB:Q15418]


organism-modification



PR:000049123

ribosomal protein S6 kinase alpha-1 phosphorylated 1 (human)

hRPS6KA1/Phos:1


"A ribosomal protein S6 kinase alpha-1 (human) that has been post-translationally modified to include phosphoserine at positions 221, 363 and 380, and phosphothreonine at position 573 of the amino acid sequence represented by UniProtKB:Q15418. UniProtKB:Q15418, Ser-221/Ser-363/Ser-380, MOD:00046|Thr-573, MOD:00047." [PRO:DAN]


organism-modification



PR:000049124

ribosomal protein S6 kinase alpha-1 phosphorylated 2 (human)

hRPS6KA1/Phos:2


"A ribosomal protein S6 kinase alpha-1 (human) that has been post-translationally modified to include phosphoserine at positions 221, 363, 380 and 732, and phosphothreonine at positions 359 and 573 of the amino acid sequence represented by UniProtKB:Q15418. UniProtKB:Q15418, Ser-221/Ser-363/Ser-380/Ser-732, MOD:00046|Thr-359/Thr-573, MOD:00047." [PRO:DNx, Reactome:R-HSA-199829]


organism-modification



PR:000060698

ribosomal protein S6 kinase alpha-1 phosphorylated 3 (human)

hRPS6KA1/Phos:3


"A ribosomal protein S6 kinase alpha-1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-359, Ser-363, Ser-380, Thr-573, and Ser-732 of the amino acid sequence represented by UniProtKB:Q15418-1. Example: UniProtKB:Q15418-1, Thr-359/Thr-573, MOD:00047|Ser-363/Ser-380/Ser-732, MOD:00046." [PRO:DNx, Reactome:R-HSA-9619993]


organism-modification



PR:000060857

ribosomal protein S6 kinase alpha-1 phosphorylated 4 (human)

hRPS6KA1/Phos:4


"A ribosomal protein S6 kinase alpha-1 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-359, Ser-363, and Thr-573 of the amino acid sequence represented by UniProtKB:Q15418-1. Example: UniProtKB:Q15418-1, Thr-359/Thr-573, MOD:00047|Ser-363, MOD:00046." [PRO:DNx, Reactome:R-HSA-9619957]


organism-modification



PR:000067309

ribosomal protein S6 kinase alpha-1 phosphorylated 5 (human)

hRPS6KA1/Phos:5


"A ribosomal protein S6 kinase alpha-1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-45 of the amino acid sequence represented by UniProtKB:Q15418-1. Example: UniProtKB:Q15418-1, Ser-45, MOD:00046." [IEDB_epitope:609243, PRO:DNx]


organism-gene



PR:Q63531

ribosomal protein S6 kinase alpha-1 (rat)

rRPS6KA1


"A ribosomal protein S6 kinase alpha-1 that is encoded in the genome of rat." [OMA:Q63531, PRO:DNx]


gene



PR:000014283

ribosomal protein S6 kinase alpha-2

RPS6KA2


"A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q15349

ribosomal protein S6 kinase alpha-2 (human)

hRPS6KA2


"A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15349]


organism-sequence



PR:Q15349-1

ribosomal protein S6 kinase alpha-2 isoform 1 (human)

hRPS6KA2/iso:1


"A ribosomal protein S6 kinase alpha-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q15349-2

ribosomal protein S6 kinase alpha-2 isoform h2 (human)

hRPS6KA2/iso:h2


"A ribosomal protein S6 kinase alpha-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15349-2." [PRO:DNx, UniProtKB:Q15349]


organism-sequence



PR:Q15349-3

ribosomal protein S6 kinase alpha-2 isoform h3 (human)

hRPS6KA2/iso:h3


"A ribosomal protein S6 kinase alpha-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15349-3." [PRO:DNx, UniProtKB:Q15349]


organism-modification



PR:000049126

ribosomal protein S6 kinase alpha-2 phosphorylated 1 (human)

hRPS6KA2/Phos:1


"A ribosomal protein S6 kinase alpha-2 (human) that has been post-translationally modified to include phosphoserine at positions 218, 360 and 377, and phosphothreonine at position 570 of the amino acid sequence represented by UniProtKB:Q15349. UniProtKB:Q15349, Ser-218/Ser-360/Ser-377, MOD:00046|Thr-570, MOD:00047." [PRO:DNx, Reactome:R-HSA-444290]


organism-modification



PR:000049127

ribosomal protein S6 kinase alpha-2 phosphorylated 2 (human)

hRPS6KA2/Phos:2


"A ribosomal protein S6 kinase alpha-2 (human) that has been post-translationally modified to include phosphoserine at positions 218, 360, 377 and 730, and phosphothreonine at positions 356 and 570 of the amino acid sequence represented by UniProtKB:Q15349. UniProtKB:Q15349, Ser-218/Ser-360/Ser-377/Ser-730, MOD:00046|Thr-356/Thr-570, MOD:00047." [PRO:DNx, Reactome:R-HSA-199871]


organism-modification



PR:000061368

ribosomal protein S6 kinase alpha-2 phosphorylated 3 (human)

hRPS6KA2/Phos:3


"A ribosomal protein S6 kinase alpha-2 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-356, Ser-360, and Thr-570 of the amino acid sequence represented by UniProtKB:Q15349-1. Example: UniProtKB:Q15349-1, Thr-356/Thr-570, MOD:00047|Ser-360, MOD:00046." [PRO:DNx, Reactome:R-HSA-9619955]


organism-gene



PR:Q9WUT3

ribosomal protein S6 kinase alpha-2 (mouse)

mRPS6KA2


"A ribosomal protein S6 kinase alpha-2 that is encoded in the genome of mouse." [OMA:Q9WUT3, PRO:DNx]


organism-sequence



PR:Q9WUT3-1

ribosomal protein S6 kinase alpha-2 isoform 1 (mouse)

mRPS6KA2/iso:1


"A ribosomal protein S6 kinase alpha-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000040622

ribosomal protein S6 kinase alpha-2 isoform 1

RPS6KA2/iso:1


"A ribosomal protein S6 kinase alpha-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15349-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q15349-1

ribosomal protein S6 kinase alpha-2 isoform 1 (human)

hRPS6KA2/iso:1


"A ribosomal protein S6 kinase alpha-2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9WUT3-1

ribosomal protein S6 kinase alpha-2 isoform 1 (mouse)

mRPS6KA2/iso:1


"A ribosomal protein S6 kinase alpha-2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000014284

ribosomal protein S6 kinase alpha-3

RPS6KA3


"A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P18654

ribosomal protein S6 kinase alpha-3 (mouse)

mRPS6KA3


"A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of mouse." [OMA:P18654, PRO:DNx]


organism-sequence



PR:P18654-1

ribosomal protein S6 kinase alpha-3 isoform 1 (mouse)

mRPS6KA3/iso:1


"A ribosomal protein S6 kinase alpha-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:P51812

ribosomal protein S6 kinase alpha-3 (human)

hRPS6KA3


"A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P51812]


organism-sequence



PR:P51812-1

ribosomal protein S6 kinase alpha-3 isoform 1 (human)

hRPS6KA3/iso:1


"A ribosomal protein S6 kinase alpha-3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-modification



PR:000049129

ribosomal protein S6 kinase alpha-3 phosphorylated 1 (human)

hRPS6KA3/Phos:1


"A ribosomal protein S6 kinase alpha-3 (human) that has been post-translationally modified to include phosphoserine at positions 227, 369, 386, and 737, and phosphothreonine at position 365, and 577 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Ser-227/Ser-369/Ser-386/Ser-737, MOD:00046|Thr-365/Thr-577, MOD:00047." [PRO:DAN, Reactome:R-HSA-444286]


organism-modification



PR:000049130

ribosomal protein S6 kinase alpha-3 phosphorylated 2 (human)

hRPS6KA3/Phos:2


"A ribosomal protein S6 kinase alpha-3 (human) that has been post-translationally modified to include phosphoserine at positions 227, 369, 386 and 715, and phosphothreonine at positions 231 and 365 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Ser-227/Ser-369/Ser-386/Ser-715, MOD:00046|Thr-231/Thr-365, MOD:00047." [PRO:DNx, Reactome:R-HSA-199830]


organism-modification



PR:000062548

ribosomal protein S6 kinase alpha-3 phosphorylated 3 (human)

hRPS6KA3/Phos:3


"A ribosomal protein S6 kinase alpha-3 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-365, Ser-369, and Thr-577 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Thr-365/Thr-577, MOD:00047|Ser-369, MOD:00046." [PRO:DNx, Reactome:R-HSA-9619959]


organism-modification



PR:000070426

ribosomal protein S6 kinase alpha-3 phosphorylated 4 (human)

hRPS6KA3/Phos:4


"A ribosomal protein S6 kinase alpha-3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-227 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Ser-227, MOD:00046." [IEDB_epitope:926489, PRO:DNx]


organism-modification



PR:000072897

ribosomal protein S6 kinase alpha-3 cysteinylated 1 (human)

hRPS6KA3/Cyst:1


"A ribosomal protein S6 kinase alpha-3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-229 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Cys-229, MOD:00765." [IEDB_epitope:1334403, PRO:DNx]


organism-modification



PR:000074808

ribosomal protein S6 kinase alpha-3 methylated 1 (human)

hRPS6KA3/Me:1


"A ribosomal protein S6 kinase alpha-3 (human) that has been methylated on the residue at the position equivalent to Cys-560 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Cys-560, MOD:00660." [IEDB_epitope:1041809, PRO:DNx]


sequence



PR:000039683

ribosomal protein S6 kinase alpha-3 isoform 1

RPS6KA3/iso:1


"A ribosomal protein S6 kinase alpha-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51812-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P18654-1

ribosomal protein S6 kinase alpha-3 isoform 1 (mouse)

mRPS6KA3/iso:1


"A ribosomal protein S6 kinase alpha-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:P51812-1

ribosomal protein S6 kinase alpha-3 isoform 1 (human)

hRPS6KA3/iso:1


"A ribosomal protein S6 kinase alpha-3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


gene



PR:000014285

ribosomal protein S6 kinase alpha-4

RPS6KA4


"A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O75676

ribosomal protein S6 kinase alpha-4 (human)

hRPS6KA4


"A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O75676]


organism-sequence



PR:O75676-1

ribosomal protein S6 kinase alpha-4 isoform 1 (human)

hRPS6KA4/iso:1


"A ribosomal protein S6 kinase alpha-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75676-1." [PRO:DNx, UniProtKB:O75676]


organism-sequence



PR:O75676-2

ribosomal protein S6 kinase alpha-4 isoform h2 (human)

hRPS6KA4/iso:h2


"A ribosomal protein S6 kinase alpha-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75676-2." [PRO:DNx, UniProtKB:O75676]


organism-modification



PR:000045611

ribosomal protein S6 kinase alpha-4 phosphorylated 1 (human)

hRPS6KA4/Phos:1


"A ribosomal protein S6 kinase alpha-4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-196 of the amino acid sequence represented by UniProtKB:O75676-1. Example: UniProtKB:O75676-1, Ser-196, MOD:00046." [iPTMnet:O75676, PMID:17429437]


organism-gene



PR:Q9Z2B9

ribosomal protein S6 kinase alpha-4 (mouse)

mRPS6KA4


"A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of mouse." [OMA:Q9Z2B9, PRO:DNx]


gene



PR:000014286

ribosomal protein S6 kinase alpha-5

RPS6KA5


"A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA5 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O75582

ribosomal protein S6 kinase alpha-5 (human)

hRPS6KA5


"A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O75582]


organism-sequence



PR:O75582-1

ribosomal protein S6 kinase alpha-5 isoform 1 (human)

hRPS6KA5/iso:1


"A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-1." [PRO:DNx, UniProtKB:O75582]


organism-sequence



PR:O75582-2

ribosomal protein S6 kinase alpha-5 isoform h2 (human)

hRPS6KA5/iso:h2


"A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-2." [PRO:DNx, UniProtKB:O75582]


organism-sequence



PR:O75582-3

ribosomal protein S6 kinase alpha-5 isoform h3 (human)

hRPS6KA5/iso:h3


"A ribosomal protein S6 kinase alpha-5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75582-3." [PRO:DNx, UniProtKB:O75582]


organism-modification



PR:000045609

ribosomal protein S6 kinase alpha-5 phosphorylated 1 (human)

hRPS6KA5/Phos:1


"A ribosomal protein S6 kinase alpha-5 (human) that has been phosphorylated on the residue at the position equivalent to Thr-581 of the amino acid sequence represented by UniProtKB:O75582-1. Example: UniProtKB:O75582-1, Thr-581, MOD:00047." [iPTMnet:O75582, PMID:17429437]


organism-modification



PR:000049132

ribosomal protein S6 kinase alpha-5 phosphorylated 2 (human)

hRPS6KA5/Phos:2


"A ribosomal protein S6 kinase alpha-5 (human) that has been post-translationally modified to include phosphoserine at positions 212, 360 and 376, and phosphothreonine at position 581 of the amino acid sequence represented by UniProtKB:O75582. UniProtKB:O75582, Ser-212/Ser-360/Ser-376, MOD:00046|Thr-581, MOD:00047." [PRO:DNx, Reactome:R-HSA-198683]


organism-gene



PR:Q5F3L1

ribosomal protein S6 kinase alpha-5 (chicken)

chick-RPS6KA5


"A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of chicken." [OMA:Q5F3L1, PRO:DNx]


organism-gene



PR:Q8C050

ribosomal protein S6 kinase alpha-5 (mouse)

mRPS6KA5


"A ribosomal protein S6 kinase alpha-5 that is encoded in the genome of mouse." [OMA:MOUSE05119, PRO:DNx]


organism-sequence



PR:Q8C050-1

ribosomal protein S6 kinase alpha-5 isoform m2 (mouse)

mRPS6KA5/iso:m2


"A ribosomal protein S6 kinase alpha-5 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C050-1." [PRO:DNx, UniProtKB:Q8C050]


organism-sequence



PR:Q8C050-2

ribosomal protein S6 kinase alpha-5 isoform m1 (mouse)

mRPS6KA5/iso:m1


"A ribosomal protein S6 kinase alpha-5 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C050-2." [PRO:DNx, UniProtKB:Q8C050]


organism-modification



PR:000049841

ribosomal protein S6 kinase alpha-5 phosphorylated 1 (mouse)

mRPS6KA5/Phos:1


"A ribosomal protein S6 kinase alpha-5 (mouse) that has been phosphorylated on the residue at the position equivalent to Thr-645 of the amino acid sequence represented by UniProtKB:Q8C050-1. Example: UniProtKB:Q8C050-1, Thr-645, MOD:00047." [PMID:27998980, PRO:LN]


gene



PR:000014287

ribosomal protein S6 kinase alpha-6

RPS6KA6


"A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA6 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q6PFQ0

ribosomal protein S6 kinase alpha-6 (zebrafish)

z-RPS6KA6


"A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of zebrafish." [PRO:DNx]


organism-gene



PR:Q7TPS0

ribosomal protein S6 kinase alpha-6 (mouse)

mRPS6KA6


"A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of mouse." [OMA:MOUSE25189, PRO:DNx]


organism-sequence



PR:E9QK39

ribosomal protein S6 kinase alpha-6 isoform m4 (mouse)

mRPS6KA6/iso:m4


"A ribosomal protein S6 kinase alpha-6 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:E9QK39." [PRO:HJD]


organism-modification



PR:000049868

ribosomal protein S6 kinase alpha-6 isoform m4 phosphorylated 1 (mouse)

mRPS6KA6/iso:m4/Phos:1


"A ribosomal protein S6 kinase alpha-6 isoform m4 (mouse) that has been phosphorylated at position Ser-505. UniProtKB:E9QK39, Ser-505, MOD:00046." [PMID:21183079, PRO:HJD]


organism-sequence



PR:Q7TPS0-1

ribosomal protein S6 kinase alpha-6 isoform m1 (mouse)

mRPS6KA6/iso:m1


"A ribosomal protein S6 kinase alpha-6 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TPS0-1." [PRO:DNx, UniProtKB:Q7TPS0]


organism-sequence



PR:Q7TPS0-2

ribosomal protein S6 kinase alpha-6 isoform m2 (mouse)

mRPS6KA6/iso:m2


"A ribosomal protein S6 kinase alpha-6 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TPS0-2." [PRO:DNx, UniProtKB:Q7TPS0]


organism-sequence



PR:Q7TPS0-3

ribosomal protein S6 kinase alpha-6 isoform m3 (mouse)

mRPS6KA6/iso:m3


"A ribosomal protein S6 kinase alpha-6 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7TPS0-3." [PRO:DNx, UniProtKB:Q7TPS0]


organism-gene



PR:Q9UK32

ribosomal protein S6 kinase alpha-6 (human)

hRPS6KA6


"A ribosomal protein S6 kinase alpha-6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UK32]


organism-sequence



PR:Q9UK32-1

ribosomal protein S6 kinase alpha-6 isoform h1 (human)

hRPS6KA6/iso:h1


"A ribosomal protein S6 kinase alpha-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UK32-1." [PRO:DNx, UniProtKB:Q9UK32]


organism-sequence



PR:Q9UK32-2

ribosomal protein S6 kinase alpha-6 isoform h2 (human)

hRPS6KA6/iso:h2


"A ribosomal protein S6 kinase alpha-6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UK32-2." [PRO:DNx, UniProtKB:Q9UK32]


organism-modification



PR:000049133

ribosomal protein S6 kinase alpha-6 phosphorylated 1 (human)

hRPS6KA6/Phos:1


"A ribosomal protein S6 kinase alpha-6 (human) that has been phosphorylated on residues at positions equivalent to Ser-232, Ser-372, Ser-389, and Thr-581 of the amino acid sequence represented by UniProtKB:Q9UK32-1. Example: UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389, MOD:00046|Thr-581, MOD:00047." [PMID:15632195, PRO:DNx, PRO:KER]

Yes

organism-modification



PR:000049860

ribosomal protein S6 kinase alpha-6 unphosphorylated 1 (human)

hRPS6KA6/UnPhos:1


"A ribosomal protein S6 kinase alpha-6 (human) that lacks phosphorylation on residues at positions equivalent to Ser-232, Ser-372, Ser-389, Thr-581 of the amino acid sequence represented by UniProtKB:Q9UK32-1. Example: UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389/Thr-581, PR:000026291." [PMID:15632195, PRO:KER]


organism-modification



PR:000063107

ribosomal protein S6 kinase alpha-6 phosphorylated 2 (human)

hRPS6KA6/Phos:2


"A ribosomal protein S6 kinase alpha-6 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-368, Ser-372, Ser-389, Thr-581, and Ser-742 of the amino acid sequence represented by UniProtKB:Q9UK32-1. Example: UniProtKB:Q9UK32-1, Thr-368/Thr-581, MOD:00047|Ser-372/Ser-389/Ser-742, MOD:00046." [PRO:DNx, Reactome:R-HSA-9619985]


organism-modification



PR:000063168

ribosomal protein S6 kinase alpha-6 phosphorylated 3 (human)

hRPS6KA6/Phos:3


"A ribosomal protein S6 kinase alpha-6 (human) that has been phosphorylated on the residues at the positions equivalent to Thr-368, Ser-372, and Thr-581 of the amino acid sequence represented by UniProtKB:Q9UK32-1. Example: UniProtKB:Q9UK32-1, Thr-368/Thr-581, MOD:00047|Ser-372, MOD:00046." [PRO:DNx, Reactome:R-HSA-9619958]


organism-modification



PR:000064014

ribosomal protein S6 kinase alpha-6 phosphorylated 4 (human)

hRPS6KA6/Phos:4


"A ribosomal protein S6 kinase alpha-6 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-232, Thr-368, Ser-372, Ser-389, Thr-581, and Ser-742 of the amino acid sequence represented by UniProtKB:Q9UK32-1. Example: UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389/Ser-742, MOD:00046|Thr-368/Thr-581, MOD:00047." [PRO:DNx, Reactome:R-HSA-9619870]


gene



PR:000029914

ribosomal protein S6 kinase 2 alpha

rps6ka


"A ribosomal protein S6 kinase alpha that is a translation product of the frog rps6ka gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P10665

ribosomal protein S6 kinase 2 alpha (frog)

frog-rps6ka


"A ribosomal protein S6 kinase 2 alpha that is encoded in the genome of frog." [PMID:11231148, PRO:KER]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029187 Firm-sspA/SigPep-
There are two functional kinase domains that are activated in a sequential manner by a series of phosphorylations
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PIRSF:PIRSF000606
GO:0070371 ERK1 and ERK2 cascade PIRSF:PIRSF000606
PR:000049133 hRPS6KA6/Phos:1
Example: UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389, MOD:00046|Thr-581, MOD:00047
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000049860 hRPS6KA6/UnPhos:1 PMID:15632195
PR:P10665 frog-rps6ka enablesGO:0016301 kinase activity PMID:11231148