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Protein Ontology report - ribosomal protein S6 kinase alpha
PR:000029187 - http://purl.obolibrary.org/obo/PR_000029187
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000029187   
  PRO nameribosomal protein S6 kinase alpha 
  Synonyms
Other: EXACT:MAPK-activated protein kinase-1 | MAPKAP-K1 | p90 ribosomal S6 kinase | p90RSK | ribosomal protein S6 kinase II
  Definition"A protein that has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069) followed by a Protein kinase C terminal domain (Pfam:PF00433) and another copy of the a Protein kinase domain (Pfam:PF00069). Prototype members of this class act downstream of ERK1/2 signaling pahtway. There are two functional kinase domains that are activated in a sequential manner by a series of phosphorylations." [PMID:10411321, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 17                                        
         Sequence2                                                  Organism-Sequence 23                                        
         Modification0                                                  Organism-Modification 24                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000606
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000029187 ribosomal protein S6 kinase alpha
Firm-sspA/SigPep-
Yes
gene


PR:000014282 ribosomal protein S6 kinase alpha-1
RPS6KA1

organism-gene


PR:P18652 ribosomal protein S6 kinase 2 alpha (chicken)
chick-RPS6KA1

organism-gene


PR:P18653 ribosomal protein S6 kinase alpha-1 (mouse)
mRPS6KA1

organism-gene


PR:Q15418 ribosomal protein S6 kinase alpha-1 (human)
hRPS6KA1

organism-sequence


PR:Q15418-1 ribosomal protein S6 kinase alpha-1 isoform h1 (human)
hRPS6KA1/iso:h1

organism-sequence


PR:Q15418-2 ribosomal protein S6 kinase alpha-1 isoform h2 (human)
hRPS6KA1/iso:h2

organism-sequence


PR:Q15418-3 ribosomal protein S6 kinase alpha-1 isoform h3 (human)
hRPS6KA1/iso:h3

organism-sequence


PR:Q15418-4 ribosomal protein S6 kinase alpha-1 isoform h4 (human)
hRPS6KA1/iso:h4

organism-modification


PR:000049123 ribosomal protein S6 kinase alpha-1 phosphorylated 1 (human)
hRPS6KA1/Phos:1

organism-modification


PR:000049124 ribosomal protein S6 kinase alpha-1 phosphorylated 2 (human)
hRPS6KA1/Phos:2

organism-modification


PR:000060698 ribosomal protein S6 kinase alpha-1 phosphorylated 3 (human)
hRPS6KA1/Phos:3

organism-modification


PR:000060857 ribosomal protein S6 kinase alpha-1 phosphorylated 4 (human)
hRPS6KA1/Phos:4

organism-modification


PR:000067309 ribosomal protein S6 kinase alpha-1 phosphorylated 5 (human)
hRPS6KA1/Phos:5

organism-gene


PR:Q63531 ribosomal protein S6 kinase alpha-1 (rat)
rRPS6KA1

gene


PR:000014283 ribosomal protein S6 kinase alpha-2
RPS6KA2

organism-gene


PR:Q15349 ribosomal protein S6 kinase alpha-2 (human)
hRPS6KA2

organism-sequence


PR:Q15349-1 ribosomal protein S6 kinase alpha-2 isoform 1 (human)
hRPS6KA2/iso:1

organism-sequence


PR:Q15349-2 ribosomal protein S6 kinase alpha-2 isoform h2 (human)
hRPS6KA2/iso:h2

organism-sequence


PR:Q15349-3 ribosomal protein S6 kinase alpha-2 isoform h3 (human)
hRPS6KA2/iso:h3

organism-modification


PR:000049126 ribosomal protein S6 kinase alpha-2 phosphorylated 1 (human)
hRPS6KA2/Phos:1

organism-modification


PR:000049127 ribosomal protein S6 kinase alpha-2 phosphorylated 2 (human)
hRPS6KA2/Phos:2

organism-modification


PR:000061368 ribosomal protein S6 kinase alpha-2 phosphorylated 3 (human)
hRPS6KA2/Phos:3

organism-gene


PR:Q9WUT3 ribosomal protein S6 kinase alpha-2 (mouse)
mRPS6KA2

organism-sequence


PR:Q9WUT3-1 ribosomal protein S6 kinase alpha-2 isoform 1 (mouse)
mRPS6KA2/iso:1

sequence


PR:000040622 ribosomal protein S6 kinase alpha-2 isoform 1
RPS6KA2/iso:1

organism-sequence


PR:Q15349-1 ribosomal protein S6 kinase alpha-2 isoform 1 (human)
hRPS6KA2/iso:1

organism-sequence


PR:Q9WUT3-1 ribosomal protein S6 kinase alpha-2 isoform 1 (mouse)
mRPS6KA2/iso:1

gene


PR:000014284 ribosomal protein S6 kinase alpha-3
RPS6KA3

organism-gene


PR:P18654 ribosomal protein S6 kinase alpha-3 (mouse)
mRPS6KA3

organism-sequence


PR:P18654-1 ribosomal protein S6 kinase alpha-3 isoform 1 (mouse)
mRPS6KA3/iso:1

organism-gene


PR:P51812 ribosomal protein S6 kinase alpha-3 (human)
hRPS6KA3

organism-sequence


PR:P51812-1 ribosomal protein S6 kinase alpha-3 isoform 1 (human)
hRPS6KA3/iso:1

organism-modification


PR:000049129 ribosomal protein S6 kinase alpha-3 phosphorylated 1 (human)
hRPS6KA3/Phos:1

organism-modification


PR:000049130 ribosomal protein S6 kinase alpha-3 phosphorylated 2 (human)
hRPS6KA3/Phos:2

organism-modification


PR:000062548 ribosomal protein S6 kinase alpha-3 phosphorylated 3 (human)
hRPS6KA3/Phos:3

organism-modification


PR:000070426 ribosomal protein S6 kinase alpha-3 phosphorylated 4 (human)
hRPS6KA3/Phos:4

organism-modification


PR:000072897 ribosomal protein S6 kinase alpha-3 cysteinylated 1 (human)
hRPS6KA3/Cyst:1

organism-modification


PR:000074808 ribosomal protein S6 kinase alpha-3 methylated 1 (human)
hRPS6KA3/Me:1

sequence


PR:000039683 ribosomal protein S6 kinase alpha-3 isoform 1
RPS6KA3/iso:1

organism-sequence


PR:P18654-1 ribosomal protein S6 kinase alpha-3 isoform 1 (mouse)
mRPS6KA3/iso:1

organism-sequence


PR:P51812-1 ribosomal protein S6 kinase alpha-3 isoform 1 (human)
hRPS6KA3/iso:1

gene


PR:000014285 ribosomal protein S6 kinase alpha-4
RPS6KA4

organism-gene


PR:O75676 ribosomal protein S6 kinase alpha-4 (human)
hRPS6KA4

organism-sequence


PR:O75676-1 ribosomal protein S6 kinase alpha-4 isoform 1 (human)
hRPS6KA4/iso:1

organism-sequence


PR:O75676-2 ribosomal protein S6 kinase alpha-4 isoform h2 (human)
hRPS6KA4/iso:h2

organism-modification


PR:000045611 ribosomal protein S6 kinase alpha-4 phosphorylated 1 (human)
hRPS6KA4/Phos:1

organism-gene


PR:Q9Z2B9 ribosomal protein S6 kinase alpha-4 (mouse)
mRPS6KA4

gene


PR:000014286 ribosomal protein S6 kinase alpha-5
RPS6KA5

organism-gene


PR:O75582 ribosomal protein S6 kinase alpha-5 (human)
hRPS6KA5

organism-sequence


PR:O75582-1 ribosomal protein S6 kinase alpha-5 isoform 1 (human)
hRPS6KA5/iso:1

organism-sequence


PR:O75582-2 ribosomal protein S6 kinase alpha-5 isoform h2 (human)
hRPS6KA5/iso:h2

organism-sequence


PR:O75582-3 ribosomal protein S6 kinase alpha-5 isoform h3 (human)
hRPS6KA5/iso:h3

organism-modification


PR:000045609 ribosomal protein S6 kinase alpha-5 phosphorylated 1 (human)
hRPS6KA5/Phos:1

organism-modification


PR:000049132 ribosomal protein S6 kinase alpha-5 phosphorylated 2 (human)
hRPS6KA5/Phos:2

organism-gene


PR:Q5F3L1 ribosomal protein S6 kinase alpha-5 (chicken)
chick-RPS6KA5

organism-gene


PR:Q8C050 ribosomal protein S6 kinase alpha-5 (mouse)
mRPS6KA5

organism-sequence


PR:Q8C050-1 ribosomal protein S6 kinase alpha-5 isoform m2 (mouse)
mRPS6KA5/iso:m2

organism-sequence


PR:Q8C050-2 ribosomal protein S6 kinase alpha-5 isoform m1 (mouse)
mRPS6KA5/iso:m1

organism-modification


PR:000049841 ribosomal protein S6 kinase alpha-5 phosphorylated 1 (mouse)
mRPS6KA5/Phos:1

gene


PR:000014287 ribosomal protein S6 kinase alpha-6
RPS6KA6

organism-gene


PR:Q6PFQ0 ribosomal protein S6 kinase alpha-6 (zebrafish)
z-RPS6KA6

organism-gene


PR:Q7TPS0 ribosomal protein S6 kinase alpha-6 (mouse)
mRPS6KA6

organism-sequence


PR:E9QK39 ribosomal protein S6 kinase alpha-6 isoform m4 (mouse)
mRPS6KA6/iso:m4

organism-modification


PR:000049868 ribosomal protein S6 kinase alpha-6 isoform m4 phosphorylated 1 (mouse)
mRPS6KA6/iso:m4/Phos:1

organism-sequence


PR:Q7TPS0-1 ribosomal protein S6 kinase alpha-6 isoform m1 (mouse)
mRPS6KA6/iso:m1

organism-sequence


PR:Q7TPS0-2 ribosomal protein S6 kinase alpha-6 isoform m2 (mouse)
mRPS6KA6/iso:m2

organism-sequence


PR:Q7TPS0-3 ribosomal protein S6 kinase alpha-6 isoform m3 (mouse)
mRPS6KA6/iso:m3

organism-gene


PR:Q9UK32 ribosomal protein S6 kinase alpha-6 (human)
hRPS6KA6

organism-sequence


PR:Q9UK32-1 ribosomal protein S6 kinase alpha-6 isoform h1 (human)
hRPS6KA6/iso:h1

organism-sequence


PR:Q9UK32-2 ribosomal protein S6 kinase alpha-6 isoform h2 (human)
hRPS6KA6/iso:h2

organism-modification


PR:000049133 ribosomal protein S6 kinase alpha-6 phosphorylated 1 (human)
hRPS6KA6/Phos:1
Yes
organism-modification


PR:000049860 ribosomal protein S6 kinase alpha-6 unphosphorylated 1 (human)
hRPS6KA6/UnPhos:1

organism-modification


PR:000063107 ribosomal protein S6 kinase alpha-6 phosphorylated 2 (human)
hRPS6KA6/Phos:2

organism-modification


PR:000063168 ribosomal protein S6 kinase alpha-6 phosphorylated 3 (human)
hRPS6KA6/Phos:3

organism-modification


PR:000064014 ribosomal protein S6 kinase alpha-6 phosphorylated 4 (human)
hRPS6KA6/Phos:4

gene


PR:000029914 ribosomal protein S6 kinase 2 alpha
rps6ka

organism-gene


PR:P10665 ribosomal protein S6 kinase 2 alpha (frog)
frog-rps6ka
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029187 Firm-sspA/SigPep-
There are two functional kinase domains that are activated in a sequential manner by a series of phosphorylations		 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PIRSF:PIRSF000606
GO:0070371 ERK1 and ERK2 cascade PIRSF:PIRSF000606
PR:000049133 hRPS6KA6/Phos:1
Example: UniProtKB:Q9UK32-1, Ser-232/Ser-372/Ser-389, MOD:00046|Thr-581, MOD:00047		 enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000049860 hRPS6KA6/UnPhos:1 PMID:15632195
PR:P10665 frog-rps6ka enablesGO:0016301 kinase activity PMID:11231148