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Protein Ontology report - sterol regulatory element-binding protein
PR:000028988 - http://purl.obolibrary.org/obo/PR_000028988
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000028988   
  PRO namesterol regulatory element-binding protein 
  Synonyms
Other: EXACT:sterol regulatory element-binding transcription factor
RELATED:SRE | SREBF | SREBP
  Definition"A protein that is a transmembrane protein where the N- and C-termini are both cytosolic, and the N terminus contains a basic helix-loop-helix domain (Pfam:PF00010) and functions as a transcription factor when cleaved off." [PMID:17303406
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 9                                        
         Sequence1                                                  Organism-Sequence 16                                        
         Modification5                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000028988

sterol regulatory element-binding protein

CDK19/iso:1


"A protein that is a transmembrane protein where the N- and C-termini are both cytosolic, and the N terminus contains a basic helix-loop-helix domain (Pfam:PF00010) and functions as a transcription factor when cleaved off." [PMID:17303406]


gene



PR:000015611

sterol regulatory element-binding protein 1

SREBF1


"A sterol regulatory element-binding protein that is a translation product of the human SREBF1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P36956

sterol regulatory element-binding protein 1 (human)

hSREBF1


"A sterol regulatory element-binding protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36956]


organism-sequence



PR:P36956-1

sterol regulatory element-binding protein 1 isoform 1 (human)

hSREBF1/iso:1


"A sterol regulatory element-binding protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028630

sterol regulatory element-binding protein 1 isoform 1 acetylated 1 (human)

hSREBF1/iso:1/Ac:1


"A sterol regulatory element-binding protein 1 isoform 1 acetylated 1 in human. UniProtKB:P36956-1, Lys-324/Lys-333, MOD:00064." [KAT:P36956, PMID:12640139, PRO:PD]


organism-sequence



PR:P36956-2

sterol regulatory element-binding protein 1 isoform hSREBP-1B (human)

hSREBF1/iso:hSREBP-1B


"A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-2." [PRO:DNx, UniProtKB:P36956]


organism-sequence



PR:P36956-3

sterol regulatory element-binding protein 1 isoform hSREBP-1C (human)

hSREBF1/iso:hSREBP-1C


"A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-3." [PRO:DNx, UniProtKB:P36956]


organism-sequence



PR:P36956-4

sterol regulatory element-binding protein 1 isoform h4 (human)

hSREBF1/iso:h4


"A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-4." [PRO:DNx, UniProtKB:P36956]


organism-sequence



PR:P36956-5

sterol regulatory element-binding protein 1 isoform hSREBP-1aDelta (human)

hSREBF1/iso:hSREBP-1aDelta


"A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-5." [PRO:DNx, UniProtKB:P36956]


organism-sequence



PR:P36956-6

sterol regulatory element-binding protein 1 isoform hSREBP-1cDelta (human)

hSREBF1/iso:hSREBP-1cDelta


"A sterol regulatory element-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-6." [PRO:DNx, UniProtKB:P36956]


organism-modification



PR:000045767

sterol regulatory element-binding protein 1 phosphorylated 1 (human)

hSREBF1/Phos:1


"A sterol regulatory element-binding protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-117 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Ser-117, MOD:00046." [iPTMnet:P36956, PMID:10915800]


organism-modification



PR:000070261

sterol regulatory element-binding protein 1 methylated 1 (human)

hSREBF1/Me:1


"A sterol regulatory element-binding protein 1 (human) that has been methylated on the residue at the position equivalent to Cys-656 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Cys-656, MOD:00660." [IEDB_epitope:1031335, PRO:DNx]


organism-modification



PR:000072398

sterol regulatory element-binding protein 1 deaminated 1 (human)

hSREBF1/Deam:1


"A sterol regulatory element-binding protein 1 (human) that has been deaminated on the residue at the position equivalent to Gln-101 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Gln-101, MOD:00685." [IEDB_epitope:1854320, PRO:DNx]


organism-modification



PR:000073406

sterol regulatory element-binding protein 1 deaminated 2 (human)

hSREBF1/Deam:2


"A sterol regulatory element-binding protein 1 (human) that has been deaminated on the residue at the position equivalent to Gln-437 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Gln-437, MOD:00685." [IEDB_epitope:1355351, PRO:DNx]


organism-modification



PR:000083130

sterol regulatory element-binding protein 1 methylated 2 (human)

hSREBF1/Me:2


"A sterol regulatory element-binding protein 1 (human) that has been methylated on the residue at the position equivalent to Cys-898 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Cys-898, MOD:00660." [IEDB_epitope:1042555, PRO:DNx]


organism-modification



PR:000083933

sterol regulatory element-binding protein 1 deaminated 3 (human)

hSREBF1/Deam:3


"A sterol regulatory element-binding protein 1 (human) that has been deaminated on the residue at the position equivalent to Asn-501 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Asn-501, MOD:00684." [IEDB_epitope:1975855, PRO:DNx]


organism-modification



PR:000084058

sterol regulatory element-binding protein 1 deaminated 4 (human)

hSREBF1/Deam:4


"A sterol regulatory element-binding protein 1 (human) that has been deaminated on the residue at the position equivalent to Gln-91 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Gln-91, MOD:00685." [IEDB_epitope:1988346, PRO:DNx]


organism-modification



PR:000084129

sterol regulatory element-binding protein 1 phosphorylated 2 (human)

hSREBF1/Phos:2


"A sterol regulatory element-binding protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-728 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Thr-728, MOD:00047." [IEDB_epitope:1349043, PRO:DNx]


organism-modification



PR:000084428

sterol regulatory element-binding protein 1 deaminated 5 (human)

hSREBF1/Deam:5


"A sterol regulatory element-binding protein 1 (human) that has been deaminated on the residue at the position equivalent to Asn-844 of the amino acid sequence represented by UniProtKB:P36956-1. Example: UniProtKB:P36956-1, Asn-844, MOD:00684." [IEDB_epitope:1348723, PRO:DNx]


organism-gene



PR:P56720

sterol regulatory element-binding protein 1 (rat)

rSREBF1


"A sterol regulatory element-binding protein 1 that is encoded in the genome of rat." [OMA:P56720, PRO:DNx]


organism-sequence



PR:P56720-1

sterol regulatory element-binding protein 1 isoform rSREBP-1C (rat)

rSREBF1/iso:rSREBP-1C


"A sterol regulatory element-binding protein 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56720-1." [PRO:DNx, UniProtKB:P56720]


organism-sequence



PR:P56720-2

sterol regulatory element-binding protein 1 isoform rSREBP-1A (rat)

rSREBF1/iso:rSREBP-1A


"A sterol regulatory element-binding protein 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56720-2." [PRO:DNx, UniProtKB:P56720]


organism-gene



PR:Q9WTN3

sterol regulatory element-binding protein 1 (mouse)

mSREBF1


"A sterol regulatory element-binding protein 1 that is encoded in the genome of mouse." [OMA:Q9WTN3, PRO:CNA]


organism-sequence



PR:Q9WTN3-1

sterol regulatory element-binding protein 1 isoform 1 (mouse)

mSREBF1/iso:1


"A sterol regulatory element-binding protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTN3-1." [PMID:16141072, PRO:HJD]

Yes

organism-sequence



PR:Q9WTN3-2

sterol regulatory element-binding protein 1 isoform 2 (mouse)

mSREBF1/iso:2


"A sterol regulatory element-binding protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTN3-2." [PMID:10052151, PRO:HJD]


organism-sequence



PR:Q9WTN3-3

sterol regulatory element-binding protein 1 isoform 3 (mouse)

mSREBF1/iso:3


"A sterol regulatory element-binding protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTN3-3." [PRO:HJD]

Yes

organism-sequence



PR:Q9WTN3-4

sterol regulatory element-binding protein 1 isoform 4 (mouse)

mSREBF1/iso:4


"A sterol regulatory element-binding protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9WTN3-4." [PMID:10052151, PRO:HJD]


sequence



PR:000028627

sterol regulatory element-binding protein 1 isoform 1

SREBF1/iso:1


"A sterol regulatory element-binding protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36956-1 or a 1:1 ortholog thereof." [PMID:12640139, PRO:PD]


organism-sequence



PR:P36956-1

sterol regulatory element-binding protein 1 isoform 1 (human)

hSREBF1/iso:1


"A sterol regulatory element-binding protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028630

sterol regulatory element-binding protein 1 isoform 1 acetylated 1 (human)

hSREBF1/iso:1/Ac:1


"A sterol regulatory element-binding protein 1 isoform 1 acetylated 1 in human. UniProtKB:P36956-1, Lys-324/Lys-333, MOD:00064." [KAT:P36956, PMID:12640139, PRO:PD]


modification



PR:000028629

sterol regulatory element-binding protein 1 isoform 1 acetylated 1

SREBF1/iso:1/Ac:1


"A sterol regulatory element-binding protein 1 isoform 1 that is acetylated on Lys residues located within the core DNA binding domain. Example: UniProtKB:P36956-1, Lys-324/Lys-333, MOD:00064." [KAT:P36956, PMID:12640139, PRO:PD]


organism-modification



PR:000028630

sterol regulatory element-binding protein 1 isoform 1 acetylated 1 (human)

hSREBF1/iso:1/Ac:1


"A sterol regulatory element-binding protein 1 isoform 1 acetylated 1 in human. UniProtKB:P36956-1, Lys-324/Lys-333, MOD:00064." [KAT:P36956, PMID:12640139, PRO:PD]


modification



PR:000021563

sterol regulatory element-binding protein 1 proteolytic cleavage product

SREBF1/ClvPrd


"A sterol regulatory element-binding protein 1 that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000015612

sterol regulatory element-binding protein 2

SREBF2


"A sterol regulatory element-binding protein that is a translation product of the human SREBF2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:A3KNA7

sterol regulatory element-binding protein 2 (zebrafish)

z-SREBF2


"A sterol regulatory element-binding protein 2 that is encoded in the genome of zebrafish." [PRO:CNA]


organism-gene



PR:Q12772

sterol regulatory element-binding protein 2 (human)

hSREBF2


"A sterol regulatory element-binding protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q12772]


organism-sequence



PR:Q12772-1

sterol regulatory element-binding protein 2 isoform h1 (human)

hSREBF2/iso:h1


"A sterol regulatory element-binding protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12772-1." [PRO:DNx, UniProtKB:Q12772]


organism-sequence



PR:Q12772-2

sterol regulatory element-binding protein 2 isoform h2 (human)

hSREBF2/iso:h2


"A sterol regulatory element-binding protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12772-2." [PRO:DNx, UniProtKB:Q12772]


organism-modification



PR:000070498

sterol regulatory element-binding protein 2 methylated 1 (human)

hSREBF2/Me:1


"A sterol regulatory element-binding protein 2 (human) that has been methylated on the residue at the position equivalent to Cys-762 of the amino acid sequence represented by UniProtKB:Q12772-1. Example: UniProtKB:Q12772-1, Cys-762, MOD:00660." [IEDB_epitope:1047056, PRO:DNx]


organism-modification



PR:000082335

sterol regulatory element-binding protein 2 methylated 2 (human)

hSREBF2/Me:2


"A sterol regulatory element-binding protein 2 (human) that has been methylated on the residue at the position equivalent to Cys-874 of the amino acid sequence represented by UniProtKB:Q12772-1. Example: UniProtKB:Q12772-1, Cys-874, MOD:00660." [IEDB_epitope:1047565, PRO:DNx]


organism-gene



PR:Q3T1I5

sterol regulatory element-binding protein 2 (rat)

rSREBF2


"A sterol regulatory element-binding protein 2 that is encoded in the genome of rat." [OMA:Q3T1I5, PRO:DNx]


organism-gene



PR:Q3U1N2

sterol regulatory element-binding protein 2 (mouse)

mSREBF2


"A sterol regulatory element-binding protein 2 that is encoded in the genome of mouse." [OMA:Q3U1N2, PRO:DNx]


organism-sequence



PR:Q3U1N2-1

sterol regulatory element-binding protein 2 isoform m1 (mouse)

mSREBF2/iso:m1


"A sterol regulatory element-binding protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3U1N2-1." [PRO:DNx, UniProtKB:Q3U1N2]


organism-sequence



PR:Q3U1N2-2

sterol regulatory element-binding protein 2 isoform m2 (mouse)

mSREBF2/iso:m2


"A sterol regulatory element-binding protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3U1N2-2." [PRO:DNx, UniProtKB:Q3U1N2]


organism-modification



PR:000085746

processed sterol regulatory element-binding protein 2 (mouse)

mSREBF2/processed


"A sterol regulatory element-binding protein 2 (mouse) that corresponds to the N-terminal portion after proteolytic cleavage by site 2 protease (aka MBTPS2 and S2P). UniProtKB:Q3U1N2, 1-473." [PRO:DAN, UniProtKB:Q3U1N2]


modification



PR:000021564

sterol regulatory element-binding protein 2 proteolytic cleavage product

SREBF2/ClvPrd


"A sterol regulatory element-binding protein 2 that has been processed by proteolytic cleavage." [PRO:DNx]


organism-modification



PR:000085746

processed sterol regulatory element-binding protein 2 (mouse)

mSREBF2/processed


"A sterol regulatory element-binding protein 2 (mouse) that corresponds to the N-terminal portion after proteolytic cleavage by site 2 protease (aka MBTPS2 and S2P). UniProtKB:Q3U1N2, 1-473." [PRO:DAN, UniProtKB:Q3U1N2]


gene



PR:000028989

sre1-type sterol regulatory element-binding protein 1

sre1


"A sterol regulatory element-binding protein that is a translation product of the Schizosaccharomyces pombe 972h- sre1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:000044709

sterol regulatory element-binding protein 1 (Schizosaccharomyces pombe)

Spom-sre1


"An sre1-type sterol regulatory element-binding protein 1 that is encoded in the genome of Schizosaccharomyces pombe." [PRO:DAN]


organism-gene



PR:Q9UUD1

sterol regulatory element-binding protein 1 (Schizosaccharomyces pombe 972h-)

Spom972h-sre1


"An sre1-type sterol regulatory element-binding protein 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:CNA, UniProtKB:Q9UUD1]


organism-modification



PR:000028992

Sre1N (Schizosaccharomyces pombe)

Spom-sre1/Clv:1


"An sre1-type sterol regulatory element-binding protein 1 cleaved 1 in Schizosaccharomyces pombe. This form is the N-terminal domain of the membrane protein sre1 that is cleaved off upon activation (e.g. by hypoxia). UniProtKB:Q9UUD1, 1-440." [PMID:22017871, PomBase:AL]


organism-gene



PR:Q9UUD1

sterol regulatory element-binding protein 1 (Schizosaccharomyces pombe 972h-)

Spom972h-sre1


"An sre1-type sterol regulatory element-binding protein 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:CNA, UniProtKB:Q9UUD1]


modification



PR:000028990

sre1-type sterol regulatory element-binding protein 1 proteolytic cleavage product

sre1/ClvPrd


"An sre1-type sterol regulatory element-binding protein 1 that has been processed by proteolytic cleavage." [PRO:CNA, PRO:DAN]


modification



PR:000028991

sre1-type sterol regulatory element-binding protein 1 cleaved 1

sre1/Clv:1


"An sre1-type sterol regulatory element-binding protein 1 that has been processed by proteolytic cleavage yielding the N-terminal domain. Example: UniProtKB:Q9UUD1, 1-440." [PMID:22017871, PRO:CNA]


organism-modification



PR:000028992

Sre1N (Schizosaccharomyces pombe)

Spom-sre1/Clv:1


"An sre1-type sterol regulatory element-binding protein 1 cleaved 1 in Schizosaccharomyces pombe. This form is the N-terminal domain of the membrane protein sre1 that is cleaved off upon activation (e.g. by hypoxia). UniProtKB:Q9UUD1, 1-440." [PMID:22017871, PomBase:AL]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9WTN3-1 mSREBF1/iso:1 enablesGO:0000976 transcription cis-regulatory region binding MGI_ref:2177036; PMID:11739104
PR:Q9WTN3-3 mSREBF1/iso:3 enablesGO:0000976 transcription cis-regulatory region binding MGI_ref:2177036; PMID:11739104