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Protein Ontology report - epidermal growth factor receptor, signal peptide removed form (human)
PR:000028422 - http://purl.obolibrary.org/obo/PR_000028422
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / GPI
  PRO ID
PR:000028422   
  PRO nameepidermal growth factor receptor, signal peptide removed form (human) 
  Synonyms
PRO-Short-label: EXACT:hEGFR/SigPep-
PRO-proteoform-std: EXACT:UniProtKB:P00533, 25-1210
NARROW:UniProtKB:P00533-1, 25-1210
PRO-proteoform-ftid: NARROW:PRO_0000016665
  Definition"An epidermal growth factor receptor, signal peptide removed form in human. Example: UniProtKB:P00533-1, 25-1210." [PRO:DNx] 
  PRO Categoryorganism-modification 
  ParentPR:000019753 epidermal growth factor receptor, signal peptide removed form
PR:P00533 epidermal growth factor receptor (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification0                                                  Organism-Modification 34                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
organism-modification


PR:000028422
epidermal growth factor receptor, signal peptide removed form (human)
hEGFR/SigPep-
"An epidermal growth factor receptor, signal peptide removed form in human. Example: UniProtKB:P00533-1, 25-1210." [PRO:DNx]

Yes
organism-modification


PR:000027477
epidermal growth factor receptor isoform 1, signal peptide removed form (human)
hEGFR/iso:1/SigPep-
"An epidermal growth factor receptor isoform 1, signal peptide removed form in human. UniProtKB:P00533-1, 25-1210." [PMID:18789131, PRO:CNA]

organism-modification


PR:000027479
epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 (human)
hEGFR/iso:1/SigPep-/Phos:1
"An epidermal growth factor receptor isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048." [PMID:18789131, PRO:PD]
Yes
organism-modification


PR:000047261
epidermal growth factor receptor, signal peptide removed phosphorylated 1 (human)
hEGFR/SigPep-/Phos:1
"An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified by autocatalysis to include phosphotyrosine at positions 1092, 1110, 1172 and 1197 of the amino acid sequence represented by UniProtKB:P00533. UniProtKB:P00533, 25-1210, Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DAN, Reactome:R-HSA-180287]

organism-modification


PR:000047262
epidermal growth factor receptor, signal peptide removed phosphorylated 2 (human)
hEGFR/SigPep-/Phos:2
"An epidermal growth factor receptor, signal peptide removed form (human) that has been post-translationally modified to include phosphotyrosine at positions 1016, 1069, 1092, 1110, 1172 and 1197 of the amino acid sequence represented by UniProtKB:P00533. UniProtKB:P00533, 25-1210, Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-179803, Reactome:R-HSA-8869138]

organism-modification


PR:000049849
epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human)
hEGFR/SigPep-/Phos:3
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PMID:10347170, PRO:KER]
Yes
organism-modification


PR:000049850
epidermal growth factor receptor, signal peptide removed unphosphorylated 3 (human)
hEGFR/SigPep-/UnPhos:3
"An epidermal growth factor receptor, signal peptide removed form (human) that lacks phosphorylation on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, PR:000026291." [PMID:10347170, PRO:KER]

organism-modification


PR:000049851
epidermal growth factor receptor, signal peptide removed phosphorylated 4 (human)
hEGFR/SigPep-/Phos:4
"An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046." [PMID:10347170, PRO:KER]
Yes
organism-modification


PR:000049852
epidermal growth factor receptor, signal peptide removed unphosphorylated 4 (human)
hEGFR/SigPep-/UnPhos:4
"An epidermal growth factor receptor, signal peptide removed form (human) that lacks phosphorylation on the residue at the position equivalent to Ser-768 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-768, PR:000026291." [PMID:10347170, PRO:KER]

organism-modification


PR:000060975
epidermal growth factor receptor sequence variant A289V, signal peptide removed phosphorylated 1 (human)
hEGFR/var:A289V/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30015|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996334]

organism-modification


PR:000060991
epidermal growth factor receptor sequence variant G719C, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G719C/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Cys residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29950|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1177530]

organism-modification


PR:000061152
epidermal growth factor receptor sequence variant G719S, signal peptide removed form (human)
hEGFR/var:G719S/SigPep-
"An epidermal growth factor receptor (human) that has a Ser residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-1169418]

organism-modification


PR:000061330
epidermal growth factor receptor sequence variant A289D, signal peptide removed phosphorylated 1 (human)
hEGFR/var:A289D/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has an Asp residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:29958|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996340]

organism-modification


PR:000061460
epidermal growth factor receptor sequence variant T263P, signal peptide removed form (human)
hEGFR/var:T263P/SigPep-
"An epidermal growth factor receptor (human) that has a Pro residue at the position equivalent to Thr-263 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Thr-263, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-1996315]

organism-modification


PR:000061481
epidermal growth factor receptor sequence variant A289T, signal peptide removed form (human)
hEGFR/var:A289T/SigPep-
"An epidermal growth factor receptor (human) that has a Thr residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-1996306]

organism-modification


PR:000061628
epidermal growth factor receptor sequence variant G719A, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G719A/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has an Ala residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:46217|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1177528]

organism-modification


PR:000061782
epidermal growth factor receptor sequence variant A289V, signal peptide removed form (human)
hEGFR/var:A289V/SigPep-
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-1996321]

organism-modification


PR:000061821
epidermal growth factor receptor sequence variant R108K, signal peptide removed form (human)
hEGFR/var:R108K/SigPep-
"An epidermal growth factor receptor (human) that has a Lys residue at the position equivalent to Arg-108 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Arg-108, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-1996330]

organism-modification


PR:000061883
epidermal growth factor receptor sequence variant A289T, signal peptide removed phosphorylated 1 (human)
hEGFR/var:A289T/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Thr residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:30013|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996341]

organism-modification


PR:000062003
epidermal growth factor receptor sequence variant L858R, signal peptide removed phosphorylated 1 (human)
hEGFR/var:L858R/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Leu-858, CHEBI:29952|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1173211]

organism-modification


PR:000062613
epidermal growth factor receptor sequence variant T790M/L858R, signal peptide removed form (human)
hEGFR/var:(T790M/L858R)/SigPep-
"An epidermal growth factor receptor (human) that has a Met residue at the position equivalent to Thr-790 and an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Thr-790, CHEBI:16044|Leu-858, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-1181386]

organism-modification


PR:000062650
epidermal growth factor receptor sequence variant T790M/L858R, signal peptide removed phosphorylated 1 (human)
hEGFR/var:(T790M/L858R)/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Met residue at the position equivalent to Thr-790 and an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Thr-790, CHEBI:16044|Leu-858, CHEBI:29952|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1182984]

organism-modification


PR:000062715
epidermal growth factor receptor sequence variant L861Q, signal peptide removed phosphorylated 1 (human)
hEGFR/var:L861Q/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Gln residue at the position equivalent to Leu-861 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Leu-861, CHEBI:30011|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1177541]

organism-modification


PR:000062731
epidermal growth factor receptor sequence variant G719A, signal peptide removed form (human)
hEGFR/var:G719A/SigPep-
"An epidermal growth factor receptor (human) that has an Ala residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-1177532]

organism-modification


PR:000062845
epidermal growth factor receptor sequence variant G598V, signal peptide removed form (human)
hEGFR/var:G598V/SigPep-
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Gly-598 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-598, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-1996314]

organism-modification


PR:000063380
epidermal growth factor receptor sequence variant A289D, signal peptide removed form (human)
hEGFR/var:A289D/SigPep-
"An epidermal growth factor receptor (human) that has an Asp residue at the position equivalent to Ala-289 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Ala-289, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-1996327]

organism-modification


PR:000063452
epidermal growth factor receptor sequence variant G598V, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G598V/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Val residue at the position equivalent to Gly-598 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-598, CHEBI:30015|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996339]

organism-modification


PR:000063536
epidermal growth factor receptor sequence variant G719S, signal peptide removed phosphorylated 1 (human)
hEGFR/var:G719S/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Ser residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29999|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1169417]

organism-modification


PR:000063584
epidermal growth factor receptor sequence variant L861Q, signal peptide removed form (human)
hEGFR/var:L861Q/SigPep-
"An epidermal growth factor receptor (human) that has a Gln residue at the position equivalent to Leu-861 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Leu-861, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-1177542]

organism-modification


PR:000063750
epidermal growth factor receptor sequence variant G719C, signal peptide removed form (human)
hEGFR/var:G719C/SigPep-
"An epidermal growth factor receptor (human) that has a Cys residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Gly-719, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-1177531]

organism-modification


PR:000063826
epidermal growth factor receptor sequence variant R108K, signal peptide removed phosphorylated 1 (human)
hEGFR/var:R108K/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Lys residue at the position equivalent to Arg-108 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Arg-108, CHEBI:29967|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996338]

organism-modification


PR:000064048
epidermal growth factor receptor sequence variant T263P, signal peptide removed phosphorylated 1 (human)
hEGFR/var:T263P/SigPep-/Phos:1
"An epidermal growth factor receptor (human) that has a Pro residue at the position equivalent to Thr-263 of the amino acid sequence represented by UniProtKB:P00533-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, Tyr-1172, and Tyr-1197. Example: UniProtKB:P00533-1, 25-1210, Thr-263, CHEBI:50342|Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1172/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-1996336]

organism-modification


PR:000064466
epidermal growth factor receptor sequence variant L858R, signal peptide removed form (human)
hEGFR/var:L858R/SigPep-
"An epidermal growth factor receptor (human) that has an Arg residue at the position equivalent to Leu-858 of the amino acid sequence represented by UniProtKB:P00533-1 and that has had the signal peptide removed. Example: UniProtKB:P00533-1, 25-1210, Leu-858, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-1173212]

organism-modification


PR:000064533
epidermal growth factor receptor, signal peptide removed phosphorylated 6 (human)
hEGFR/SigPep-/Phos:6
"An epidermal growth factor receptor (human) that has had the signal peptide removed and that has been phosphorylated on the residues at the positions equivalent to Tyr-1016, Tyr-1069, Tyr-1092, Tyr-1110, and Tyr-1197 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Tyr-1016/Tyr-1069/Tyr-1092/Tyr-1110/Tyr-1197, MOD:00048." [PRO:DNx, Reactome:R-HSA-8864019]

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hEGFR/SigPep- forms found in complexes   

hEGFR/SigPep- Component
 Complexes
PR:000028422 hEGFR/SigPep- PR:000028451 L1-EGFR trans-heterodimer (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027479 hEGFR/iso:1/SigPep-/Phos:1
UniProtKB:P00533-1, 25-1210, Tyr-869, MOD:00048		 acts_upstream_of_or_withinGO:0034504 protein localization to nucleus PMID:18789131
located_inGO:0005634 nucleus PMID:18789131
PR:000049849 hEGFR/SigPep-/Phos:3
Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046		 enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
decreased GO:0005515 protein binding relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170
PR:000049851 hEGFR/SigPep-/Phos:4
Example: UniProtKB:P00533-1, 25-1210, Ser-768, MOD:00046		 enablesdecreased GO:0004713 protein tyrosine kinase activity relative to PR:000049852 hEGFR/SigPep-/UnPhos:4 PMID:10347170