back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - basic helix-loop-helix transcription factor HAND
PR:000027804 - http://purl.obolibrary.org/obo/PR_000027804
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000027804   
  PRO namebasic helix-loop-helix transcription factor HAND 
  Synonyms
Other: EXACT:HAND
  Definition"A protein that belongs to the clade A of the bHLH proteins (see PMID:20219281) with with a C-terminal copy of the helix-loop-helix DNA-binding domain (Pfam:PF00010), and it is the translation product of the human HAND1 or HAND2 genes, or 1:1 orthologs thereof." [PMID:12909338, PMID:20219281, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 9                                        
         Sequence2                                                  Organism-Sequence 7                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000027804

basic helix-loop-helix transcription factor HAND

mHAND1/iso:1/PhosRes-


"A protein that belongs to the clade A of the bHLH proteins (see PMID:20219281) with with a C-terminal copy of the helix-loop-helix DNA-binding domain (Pfam:PF00010), and it is the translation product of the human HAND1 or HAND2 genes, or 1:1 orthologs thereof." [PMID:12909338, PMID:20219281, PRO:CNA]


gene



PR:000008439

heart- and neural crest derivatives-expressed protein 1

HAND1


"A basic helix-loop-helix transcription factor HAND that is a translation product of the human HAND1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O96004

heart- and neural crest derivatives-expressed protein 1 (human)

hHAND1


"A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O96004]


organism-sequence



PR:O96004-1

heart- and neural crest derivatives-expressed protein 1 isoform 1 (human)

hHAND1/iso:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-gene



PR:P97832

heart- and neural crest derivatives-expressed protein 1 (rat)

rHAND1


"A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of rat." [OMA:P97832, PRO:DNx]


organism-sequence



PR:P97832-1

heart- and neural crest derivatives-expressed protein 1 isoform 1 (rat)

rHAND1/iso:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-gene



PR:Q64279

heart- and neural crest derivatives-expressed protein 1 (mouse)

mHAND1


"A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of mouse." [OMA:Q64279, PRO:DNx]


organism-sequence



PR:Q64279-1

heart- and neural crest derivatives-expressed protein 1 isoform 1 (mouse)

mHAND1/iso:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of mouse." [PMID:7791788, PRO:CNA]


organism-modification



PR:000027800

heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 (mouse)

mHAND1/iso:1/Phos:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)." [PMID:17891141, PRO:HJD]


organism-modification



PR:000027802

heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form (mouse)

mHAND1/iso:1/PhosRes-


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form in mouse." [PMID:17891141, PRO:HJD]


organism-modification



PR:000085716

heart- and neural crest derivatives-expressed protein 1 phosphorylated 1 (mouse)

mHAND1/Phos:1


"A heart- and neural crest derivatives-expressed protein 1 (mouse) that has been phosphorylated at the Ser and/or Thr residues within the KER[RQ]RTxS motif located at the N terminus of the bHLH domain. Example: UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)." [PMID:21559426, PRO:DAN]


organism-gene



PR:Q90691

heart- and neural crest derivatives-expressed protein 1 (chicken)

chick-HAND1


"A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of chicken." [OMA:Q90691, PRO:DNx]


sequence



PR:000027797

heart- and neural crest derivatives-expressed protein 1 isoform 1

HAND1/iso:1


"A heart- and neural crest derivatives-expressed protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64279-1 or a 1:1 ortholog thereof." [PMID:17891141, PMID:7791788, PRO:CNA]


organism-sequence



PR:O96004-1

heart- and neural crest derivatives-expressed protein 1 isoform 1 (human)

hHAND1/iso:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P97832-1

heart- and neural crest derivatives-expressed protein 1 isoform 1 (rat)

rHAND1/iso:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-sequence



PR:Q64279-1

heart- and neural crest derivatives-expressed protein 1 isoform 1 (mouse)

mHAND1/iso:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of mouse." [PMID:7791788, PRO:CNA]


organism-modification



PR:000027800

heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 (mouse)

mHAND1/iso:1/Phos:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)." [PMID:17891141, PRO:HJD]


organism-modification



PR:000027802

heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form (mouse)

mHAND1/iso:1/PhosRes-


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form in mouse." [PMID:17891141, PRO:HJD]


modification



PR:000027799

heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1

HAND1/iso:1/Phos:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that has been phosphorylated at the Ser and/or Thr residues within the KER[RQ]RTxS motif located at the N terminus of the bHLH domain. Example: UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)." [PMID:17891141, PRO:HJD]


organism-modification



PR:000027800

heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 (mouse)

mHAND1/iso:1/Phos:1


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)." [PMID:17891141, PRO:HJD]


modification



PR:000027801

heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form

HAND1/iso:1/PhosRes-


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 that lacks phosphorylated residues." [PRO:CNA]


organism-modification



PR:000027802

heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form (mouse)

mHAND1/iso:1/PhosRes-


"A heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form in mouse." [PMID:17891141, PRO:HJD]


gene



PR:000008440

heart- and neural crest derivatives-expressed protein 2

HAND2


"A basic helix-loop-helix transcription factor HAND that is a translation product of the human HAND2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P57102

heart- and neural crest derivatives-expressed protein 2 (zebrafish)

z-HAND2


"A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of zebrafish." [OMA:P57102, PRO:DNx]


organism-gene



PR:P61295

heart- and neural crest derivatives-expressed protein 2 (rat)

rHAND2


"A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of rat." [OMA:P61295, PRO:DNx]


organism-sequence



PR:P61295-1

heart- and neural crest derivatives-expressed protein 2 isoform 1 (rat)

rHAND2/iso:1


"A heart- and neural crest derivatives-expressed protein 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:P61296

heart- and neural crest derivatives-expressed protein 2 (human)

hHAND2


"A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P61296]


organism-sequence



PR:P61296-1

heart- and neural crest derivatives-expressed protein 2 isoform 1 (human)

hHAND2/iso:1


"A heart- and neural crest derivatives-expressed protein 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:P61296-2

heart- and neural crest derivatives-expressed protein 2 isoform h2 (human)

hHAND2/iso:h2


"A heart- and neural crest derivatives-expressed protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61296-2." [PRO:DNx, UniProtKB:P61296]


organism-gene



PR:Q61039

heart- and neural crest derivatives-expressed protein 2 (mouse)

mHAND2


"A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of mouse." [OMA:Q61039, PRO:DNx]


organism-sequence



PR:Q61039-1

heart- and neural crest derivatives-expressed protein 2 isoform 1 (mouse)

mHAND2/iso:1


"A heart- and neural crest derivatives-expressed protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q90690

heart- and neural crest derivatives-expressed protein 2 (chicken)

chick-HAND2


"A heart- and neural crest derivatives-expressed protein 2 that is encoded in the genome of chicken." [OMA:Q90690, PRO:DNx]


sequence



PR:000039937

heart- and neural crest derivatives-expressed protein 2 isoform 1

HAND2/iso:1


"A heart- and neural crest derivatives-expressed protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61296-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P61295-1

heart- and neural crest derivatives-expressed protein 2 isoform 1 (rat)

rHAND2/iso:1


"A heart- and neural crest derivatives-expressed protein 2 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:P61296-1

heart- and neural crest derivatives-expressed protein 2 isoform 1 (human)

hHAND2/iso:1


"A heart- and neural crest derivatives-expressed protein 2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q61039-1

heart- and neural crest derivatives-expressed protein 2 isoform 1 (mouse)

mHAND2/iso:1


"A heart- and neural crest derivatives-expressed protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]