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Protein Ontology report - interleukin-1 receptor-associated kinase 4 isoform 1
PR:000027188 - http://purl.obolibrary.org/obo/PR_000027188
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000027188   
  PRO nameinterleukin-1 receptor-associated kinase 4 isoform 1 
  Synonyms
PRO-Short-label: EXACT:IRAK4/iso:1
  Definition"An interleukin-1 receptor-associated kinase 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NWZ3-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000001780 interleukin-1 receptor-associated kinase 4
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000027188
interleukin-1 receptor-associated kinase 4 isoform 1
IRAK4/iso:1
"An interleukin-1 receptor-associated kinase 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NWZ3-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:Q8R4K2-1
interleukin-1 receptor-associated kinase 4 isoform 1 (mouse)
mIRAK4/iso:1
"An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-sequence


PR:Q9NWZ3-1
interleukin-1 receptor-associated kinase 4 isoform 1 (human)
hIRAK4/iso:1
"An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000027191
interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
hIRAK4/iso:1/Phos:1
"An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PMID:17141195, PRO:CNA]

Yes
modification


PR:000027190
interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1
IRAK4/iso:1/Phos:1
"An interleukin-1 receptor-associated kinase 4 isoform 1 that has been phosphorylated by autocatalysis within the kinase activation loop following activation of the Toll-like receptor pathways. Example: UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PRO:CNA]

organism-modification


PR:000027191
interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
hIRAK4/iso:1/Phos:1
"An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PMID:17141195, PRO:CNA]

Yes
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IRAK4/iso:1 forms found in complexes   

IRAK4/iso:1 Component
 Complexes
PR:000027191 hIRAK4/iso:1/Phos:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)