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Protein Ontology report - Toll/interleukin-1 receptor domain-containing adapter protein isoform 1
PR:000027185 - http://purl.obolibrary.org/obo/PR_000027185
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000027185   
  PRO nameToll/interleukin-1 receptor domain-containing adapter protein isoform 1 
  Synonyms
PRO-Short-label: EXACT:TIRAP/iso:1
  Definition"A Toll/interleukin-1 receptor domain-containing adapter protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58753-1 or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 1                                        
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000027185
Toll/interleukin-1 receptor domain-containing adapter protein isoform 1
TIRAP/iso:1
"A Toll/interleukin-1 receptor domain-containing adapter protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58753-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P58753-1
Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human)
hTIRAP/iso:1
"A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes
organism-modification


PR:000027214
Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
hTIRAP/iso:1/Phos:1
"A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 in human. UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048)." [PMID:16439361, PMID:18070880, PRO:CNA]

Yes
modification


PR:000027213
Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1
TIRAP/iso:1/Phos:1
"A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that has been post-translationally modified to include phosphorylated Tyr residues within the TIR domain as a result of tyrosine kinase activation (like Bruton tyrosine kinase). Example: UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048)." [PMID:16439361, PRO:CNA]

organism-modification


PR:000027214
Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
hTIRAP/iso:1/Phos:1
"A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 in human. UniProtKB:P58753-1, (Tyr-86, MOD:00048 or Tyr-106, MOD:00048 or Tyr-159, MOD:00048)." [PMID:16439361, PMID:18070880, PRO:CNA]

Yes
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TIRAP/iso:1 forms found in complexes   

TIRAP/iso:1 Component
 Complexes
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753ZDASHZ1 hTIRAP/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)