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PRO ID
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| PRO name | neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human) |
| Synonyms | | PRO-Short-label: | EXACT: | hL1CAM/iso:1/SigPep-/Phos:1 | | PRO-proteoform-std: | EXACT: | UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048 | | PRO-proteoform-ftid: | EXACT: | PRO_0000015022, Tyr-1176, MOD:00048 |
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| Definition | "A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA] |
| Comment | Note: Tyr-1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. |
| PRO Category | organism-modification |
| Parent | PR:000026192 neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1
PR:P32004 neural cell adhesion molecule L1 (human)
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| Taxon | NCBITaxon:9606 Homo sapiens |
Term Hierarchy
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