back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1
PR:000026192 - http://purl.obolibrary.org/obo/PR_000026192
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000026192   
  PRO nameneural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 
  Synonyms
PRO-Short-label: EXACT:L1CAM/iso:1/SigPep-/Phos:1
  Definition"A neural cell adhesion molecule L1 isoform 1 that has been phosphorylated on the tyrosine residue of the tyrosine based sorting motif. The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. Example: UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000026190 neural cell adhesion molecule L1 isoform 1
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000026192
neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1
L1CAM/iso:1/SigPep-/Phos:1
"A neural cell adhesion molecule L1 isoform 1 that has been phosphorylated on the tyrosine residue of the tyrosine based sorting motif. The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. Example: UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]

organism-modification


PR:000026222
neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human)
hL1CAM/iso:1/SigPep-/Phos:1
"A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]