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sequence
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 PR:000026190 |
   neural cell adhesion molecule L1 isoform 1
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   L1CAM/iso:1
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  "A neural cell adhesion molecule L1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32004-1 or a 1:1 ortholog thereof." [PRO:CNx]
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organism-sequence
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 PR:P32004-1 |
   neural cell adhesion molecule L1 isoform 1 (human)
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   hL1CAM/iso:1
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  "A neural cell adhesion molecule L1 isoform 1 that is encoded in the genome of human." [PRO:CNx]
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organism-modification
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 PR:000026222 |
   neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human)
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   hL1CAM/iso:1/SigPep-/Phos:1
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  "A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]
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organism-sequence
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 PR:Q6PGJ3 |
   neural cell adhesion molecule L1 isoform 1 (mouse)
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   mL1CAM/iso:1
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  "A neural cell adhesion molecule L1 isoform 1 that is encoded in the genome of mouse." [PRO:CNx]
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modification
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 PR:000026192 |
   neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1
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   L1CAM/iso:1/SigPep-/Phos:1
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  "A neural cell adhesion molecule L1 isoform 1 that has been phosphorylated on the tyrosine residue of the tyrosine based sorting motif. The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. Example: UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]
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organism-modification
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 PR:000026222 |
   neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human)
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   hL1CAM/iso:1/SigPep-/Phos:1
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  "A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]
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modification
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 PR:000026686 |
   neural cell adhesion molecule L1 isoform 1, signal peptide removed form
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   L1CAM/iso:1/SigPep-
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  "A neural cell adhesion molecule L1 isoform 1 that has had the signal peptide removed." [PRO:DNx]
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