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Protein Ontology report - neural cell adhesion molecule L1 isoform 1
PR:000026190 - http://purl.obolibrary.org/obo/PR_000026190
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000026190   
  PRO nameneural cell adhesion molecule L1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:L1CAM/iso:1
  Definition"A neural cell adhesion molecule L1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32004-1 or a 1:1 ortholog thereof." [PRO:CNx] 
  PRO Categorysequence 
  ParentPR:000002066 neural cell adhesion molecule L1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000026190

neural cell adhesion molecule L1 isoform 1

L1CAM/iso:1


"A neural cell adhesion molecule L1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P32004-1 or a 1:1 ortholog thereof." [PRO:CNx]


organism-sequence



PR:P32004-1

neural cell adhesion molecule L1 isoform 1 (human)

hL1CAM/iso:1


"A neural cell adhesion molecule L1 isoform 1 that is encoded in the genome of human." [PRO:CNx]


organism-modification



PR:000026222

neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human)

hL1CAM/iso:1/SigPep-/Phos:1


"A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]


organism-sequence



PR:Q6PGJ3

neural cell adhesion molecule L1 isoform 1 (mouse)

mL1CAM/iso:1


"A neural cell adhesion molecule L1 isoform 1 that is encoded in the genome of mouse." [PRO:CNx]


modification



PR:000026192

neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1

L1CAM/iso:1/SigPep-/Phos:1


"A neural cell adhesion molecule L1 isoform 1 that has been phosphorylated on the tyrosine residue of the tyrosine based sorting motif. The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. Example: UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]


organism-modification



PR:000026222

neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human)

hL1CAM/iso:1/SigPep-/Phos:1


"A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PMID:12082080, PRO:CNA]


modification



PR:000026686

neural cell adhesion molecule L1 isoform 1, signal peptide removed form

L1CAM/iso:1/SigPep-


"A neural cell adhesion molecule L1 isoform 1 that has had the signal peptide removed." [PRO:DNx]