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Protein Ontology report - metal-dependent decarboxylating R-hydroxyacid dehydrogenase
PR:000026156 - http://purl.obolibrary.org/obo/PR_000026156
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000026156   
  PRO namemetal-dependent decarboxylating R-hydroxyacid dehydrogenase 
  Definition"A protein that is a standalone version of the Isocitrate/isopropylmalate dehydrogenase (Pfam:PF00180) domain. Members of this class have an evolutionarily distinct NAD(+)-binding domain." [PMID:8053675] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 26                                        
         Sequence5                                                  Organism-Sequence 15                                        
         Modification6                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000107
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000026156 metal-dependent decarboxylating R-hydroxyacid dehydrogenase
SPTSSB

gene


PR:000022989 isocitrate dehydrogenase [NADP]
icd

organism-gene


PR:P08200 isocitrate dehydrogenase [NADP] (Escherichia coli K-12)
Ec-icd

organism-sequence


PR:P08200-1 isocitrate dehydrogenase [NADP] isoform 1 (Escherichia coli K-12)
Ec-icd/iso:1

organism-modification


PR:000036730 isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Ac:1

organism-modification


PR:000036731 isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Phos:1
Yes
sequence


PR:000025138 isocitrate dehydrogenase [NADP] isoform 1
icd/iso:1

organism-sequence


PR:P08200-1 isocitrate dehydrogenase [NADP] isoform 1 (Escherichia coli K-12)
Ec-icd/iso:1

organism-modification


PR:000036730 isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Ac:1

organism-modification


PR:000036731 isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Phos:1
Yes
modification


PR:000025139 isocitrate dehydrogenase [NADP] isoform 1 unmodified form
icd/iso:1/UnMod

modification


PR:000025140 isocitrate dehydrogenase [NADP] isoform 1 acetylated 1
icd/iso:1/Ac:1

organism-modification


PR:000036730 isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Ac:1

modification


PR:000025141 isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1
icd/iso:1/Phos:1

organism-modification


PR:000036731 isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Phos:1
Yes
gene


PR:000023082 3-isopropylmalate dehydrogenase
leuB

organism-gene


PR:P04173 3-isopropylmalate dehydrogenase (yeast)
yleuB

organism-gene


PR:P18869 3-isopropylmalate dehydrogenase (Schizosaccharomyces pombe 972h-)
Spom972h-leuB

organism-gene


PR:P30125 3-isopropylmalate dehydrogenase (Escherichia coli K-12)
Ec-leuB

organism-gene


PR:Q2FWK2 3-isopropylmalate dehydrogenase (Staphylococcus aureus subsp. aureus NCTC 8325)
leuB (STAA8)

organism-gene


PR:Q9FMT1 3-isopropylmalate dehydrogenase 1, chloroplastic (Arabidopsis thaliana)
At-leuB

organism-sequence


PR:Q9FMT1-1 3-isopropylmalate dehydrogenase 1, chloroplastic isoform 1 (Arabidopsis thaliana)
At-leuB/iso:1

modification


PR:000024506 3-isopropylmalate dehydrogenase, initiator methionine removed form
leuB/InitMet-

family


PR:000026157 isocitrate dehydrogenase [NAD], mitochondrial
SPTSSB

gene


PR:000008889 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
IDH3A

organism-gene


PR:P50213 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (human)
hIDH3A

Yes
organism-sequence


PR:P50213-1 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 1 (human)
hIDH3A/iso:1

organism-sequence


PR:P50213-2 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 2 (human)
hIDH3A/iso:2

organism-modification


PR:000047943 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, transit peptide removed form (human)
hIDH3A/TransPep-

organism-modification


PR:000077630 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial methylated 1 (human)
hIDH3A/Me:1

organism-modification


PR:000085694 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial cysteinylated 1 (human)
hIDH3A/Cyst:1

organism-gene


PR:Q55BI2 isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial (Dictyostelium discoideum)
Dicty-IDH3A

organism-gene


PR:Q93714 probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (worm)
IDH3A (worm)

organism-gene


PR:Q99NA5 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (rat)
rIDH3A

organism-gene


PR:Q9D6R2 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (mouse)
mIDH3A

Yes
organism-sequence


PR:Q9D6R2-1 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 1 (mouse)
mIDH3A/iso:1
Yes
Yes
organism-sequence


PR:Q9D6R2-2 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 2 (mouse)
mIDH3A/iso:2

Yes
organism-gene


PR:Q9VWH4 probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (fruit fly)
fly-IDH3A

organism-sequence


PR:Q9VWH4-1 probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform D (fruit fly)
fly-IDH3A/iso:D

organism-sequence


PR:Q9VWH4-2 probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform A (fruit fly)
fly-IDH3A/iso:A

sequence


PR:000025352 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 1
IDH3A/iso:1

organism-sequence


PR:P50213-1 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 1 (human)
hIDH3A/iso:1

organism-sequence


PR:Q9D6R2-1 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 1 (mouse)
mIDH3A/iso:1
Yes
Yes
sequence


PR:000025353 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 2
IDH3A/iso:2

organism-sequence


PR:P50213-2 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 2 (human)
hIDH3A/iso:2

organism-sequence


PR:Q9D6R2-2 isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform 2 (mouse)
mIDH3A/iso:2

Yes
gene


PR:000008890 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
IDH3B

organism-gene


PR:O43837 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (human)
hIDH3B

Yes
organism-sequence


PR:O43837-1 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform B (human)
hIDH3B/iso:B

organism-sequence


PR:O43837-2 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform A (human)
hIDH3B/iso:A

organism-sequence


PR:O43837-3 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform C (human)
hIDH3B/iso:C

organism-modification


PR:000047944 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial, transit peptide removed form (human)
hIDH3B/TransPep-

organism-gene


PR:Q5ZKN9 isocitrate dehydrogenase [NAD] subunit, mitochondrial (chicken)
chick-IDH3B

organism-gene


PR:Q68FX0 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (rat)
rIDH3B

organism-sequence


PR:Q68FX0-1 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1 (rat)
rIDH3B/iso:1

organism-gene


PR:Q91VA7 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (mouse)
mIDH3B

Yes
organism-gene


PR:Q93353 probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (worm)
IDH3B (worm)

sequence


PR:000038193 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1
IDH3B/iso:1

organism-sequence


PR:O43837-1 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform B (human)
hIDH3B/iso:B

organism-sequence


PR:Q68FX0-1 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 1 (rat)
rIDH3B/iso:1

gene


PR:000008891 isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
IDH3G

organism-gene


PR:P41565 isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (rat)
rIDH3G

organism-gene


PR:P51553 isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (human)
hIDH3G

Yes
organism-sequence


PR:P51553-1 isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial isoform 1 (human)
hIDH3G/iso:1

organism-sequence


PR:P51553-2 isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial isoform h2 (human)
hIDH3G/iso:h2

organism-modification


PR:000047945 isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, transit peptide removed form (human)
hIDH3G/TransPep-

organism-gene


PR:P70404 isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (mouse)
mIDH3G

Yes
organism-sequence


PR:P70404-1 isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 (mouse)
mIDH3G/iso:1

organism-gene


PR:Q20049 isocitrate dehydrogenase [NAD] subunit, mitochondrial (worm)
IDH3G (worm)

organism-gene


PR:Q54B68 isocitrate dehydrogenase [NAD] regulatory subunit B, mitochondrial (Dictyostelium discoideum)
Dicty-IDH3G

sequence


PR:000039665 isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial isoform 1
IDH3G/iso:1

organism-sequence


PR:P51553-1 isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial isoform 1 (human)
hIDH3G/iso:1

organism-sequence


PR:P70404-1 isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 (mouse)
mIDH3G/iso:1

gene


PR:000026162 isocitrate dehydrogenase [NAD] subunit 1, mitochondrial
IDH1nad

organism-gene


PR:O13696 isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (Schizosaccharomyces pombe 972h-)
Spom972h-IDH1nad

organism-gene


PR:P28834 isocitrate dehydrogenase [NAD] subunit 1, mitochondrial (yeast)
yIDH1nad

Yes
modification


PR:000026645 isocitrate dehydrogenase [NAD] subunit 1, mitochondrial, transit peptide removed form
IDH1nad/TransPep-

gene


PR:000026164 isocitrate dehydrogenase [NAD] subunit 2, mitochondrial
IDH2nad

organism-gene


PR:P28241 isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (yeast)
yIDH2nad

Yes
organism-gene


PR:Q9USP8 isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (Schizosaccharomyces pombe 972h-)
Spom972h-IDH2nad

modification


PR:000026607 isocitrate dehydrogenase [NAD] subunit 2, mitochondrial, transit peptide removed form
IDH2nad/TransPep-

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SPTSSB forms found in complexes   

SPTSSB Component
 Complexes
PR:O43837 hIDH3B PR:000026161 mitochondrial isocitrate dehydrogenase complex (NAD+) (human)
PR:P28241 yIDH2nad PR:000026166 mitochondrial isocitrate dehydrogenase complex (NAD+) (yeast)
PR:P28834 yIDH1nad PR:000026166 mitochondrial isocitrate dehydrogenase complex (NAD+) (yeast)
PR:P50213 hIDH3A PR:000026161 mitochondrial isocitrate dehydrogenase complex (NAD+) (human)
PR:P51553 hIDH3G PR:000026161 mitochondrial isocitrate dehydrogenase complex (NAD+) (human)
PR:P70404 mIDH3G PR:000026071 mitochondrial isocitrate dehydrogenase complex (NAD+) (mouse)
PR:000026072 mitochondrial isocitrate dehydrogenase complex (NAD+) A (mouse)
PR:000026073 mitochondrial isocitrate dehydrogenase complex (NAD+) B (mouse)
PR:Q91VA7 mIDH3B PR:000026071 mitochondrial isocitrate dehydrogenase complex (NAD+) (mouse)
PR:000026072 mitochondrial isocitrate dehydrogenase complex (NAD+) A (mouse)
PR:000026073 mitochondrial isocitrate dehydrogenase complex (NAD+) B (mouse)
PR:Q9D6R2 mIDH3A PR:000026071 mitochondrial isocitrate dehydrogenase complex (NAD+) (mouse)
PR:Q9D6R2ZDASHZ1 mIDH3A/iso:1 PR:000026072 mitochondrial isocitrate dehydrogenase complex (NAD+) A (mouse)
PR:Q9D6R2ZDASHZ2 mIDH3A/iso:2 PR:000026073 mitochondrial isocitrate dehydrogenase complex (NAD+) B (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036731 Ec-icd/iso:1/Phos:1
UniProtKB:P08200-1, Ser-113, MOD:00046		 acts_upstream_of_or_withinGO:0006099 tricarboxylic acid cycle EcoCyc:ISOCITHASE-P
PR:Q9D6R2-1 mIDH3A/iso:1 located_inGO:0005739 mitochondrion MGI_ref:3852644; PMID:18614015
GO:0005739 mitochondrion MGI_ref:3852644; PMID:18614015