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Protein Ontology report - PLP-dependent alpha-oxoamine synthase
PR:000026124 - http://purl.obolibrary.org/obo/PR_000026124
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000026124   
  PRO namePLP-dependent alpha-oxoamine synthase 
  Synonyms
Other: EXACT:alpha-oxoamine synthase | OAS | POAS
  Definition"A protein that consist of a single copy of the Aminotransferase class I and II (Pfam:PF00155) domain. Alpha-oxoamine synthase corresponds to the alpha-division of pyridoxal-5'-phosphate (PLP)-dependent enzymes. Alpha-oxoamine synthase are involved in catalysis of the decarboxylative condensation of a carboxylic acid coenzyme A (CoA) thioester and an amino acid, with the amino acid being covalently bound to the PLP via a Schiff base at the beginning of the catalytic cycle." [PMID:15189147, PMID:17559874, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family3                                                  Organism-Family 0                                        
         Gene8                                                  Organism-Gene 33                                        
         Sequence5                                                  Organism-Sequence 24                                        
         Modification3                                                  Organism-Modification 16                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF800003
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000026124 PLP-dependent alpha-oxoamine synthase
hMCCC2/var:MCCB IVS3+5G->T

gene


PR:000007885 2-amino-3-ketobutyrate coenzyme A ligase
GCAT

organism-gene


PR:O75600 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (human)
hGCAT

organism-sequence


PR:O75600-1 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform h1 (human)
hGCAT/iso:h1

organism-sequence


PR:O75600-2 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform h2 (human)
hGCAT/iso:h2

organism-modification


PR:000047515 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, transit peptide removed form (human)
hGCAT/TransPep-

organism-modification


PR:000061492 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing 1 (human)
hGCAT/TransPep-/Pyrdox:1

organism-gene


PR:O88986 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (mouse)
mGCAT

organism-gene


PR:P0AB77 2-amino-3-ketobutyrate coenzyme A ligase (Escherichia coli K-12)
Ec-GCAT

organism-gene


PR:Q22768 T25B9.1 protein (worm)
GCAT (worm)

gene


PR:000022225 8-amino-7-oxononanoate synthase
bioF

organism-gene


PR:P12998 8-amino-7-oxononanoate synthase (Escherichia coli K-12)
Ec-bioF

organism-gene


PR:Q9XVI6 serine palmitoyltransferase 3 (worm)
bioF (worm)

organism-sequence


PR:Q9XVI6-1 serine palmitoyltransferase 3 isoform a (worm)
bioF/iso:a (worm)

organism-sequence


PR:Q9XVI6-2 serine palmitoyltransferase 3 isoform b (worm)
bioF/iso:b (worm)

modification


PR:000024311 8-amino-7-oxononanoate synthase, initiator methionine removed form
bioF/InitMet-

family


PR:000026125 5-aminolevulinate synthase
hMCCC2/var:MCCB IVS3+5G->T

gene


PR:000003916 5-aminolevulinate synthase, non-specific, mitochondrial
ALAS1

organism-gene


PR:P07997 5-aminolevulinate synthase, non-specific, mitochondrial (chicken)
chick-ALAS1

organism-gene


PR:P13195 5-aminolevulinate synthase, non-specific, mitochondrial (rat)
rALAS1

organism-sequence


PR:P13195-1 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (rat)
rALAS1/iso:1

organism-gene


PR:P13196 5-aminolevulinate synthase, non-specific, mitochondrial (human)
hALAS1

organism-sequence


PR:P13196-1 5-aminolevulinate synthase, non-specific, mitochondrial isoform h1 (human)
hALAS1/iso:h1

organism-sequence


PR:P13196-2 5-aminolevulinate synthase, non-specific, mitochondrial isoform h2 (human)
hALAS1/iso:h2

organism-modification


PR:000046304 5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed form (human)
hALAS1/TransPep-

organism-modification


PR:000046305 5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing form (human)
hALAS1/TransPep-/PyrdoxLys+

organism-modification


PR:000046305 5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing form (human)
hALAS1/TransPep-/PyrdoxLys+

organism-modification


PR:000066761 5-aminolevulinate synthase, non-specific, mitochondrial methylated 1 (human)
hALAS1/Me:1

organism-modification


PR:000078022 5-aminolevulinate synthase, non-specific, mitochondrial methylated 2 (human)
hALAS1/Me:2

organism-gene


PR:Q8VC19 5-aminolevulinate synthase, non-specific, mitochondrial (mouse)
mALAS1

organism-sequence


PR:Q8VC19-1 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (mouse)
mALAS1/iso:1

sequence


PR:000042113 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1
ALAS1/iso:1

organism-sequence


PR:P13195-1 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (rat)
rALAS1/iso:1

organism-sequence


PR:Q8VC19-1 5-aminolevulinate synthase, non-specific, mitochondrial isoform 1 (mouse)
mALAS1/iso:1

modification


PR:000018945 5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed form
ALAS1/TransPep-

organism-modification


PR:000046304 5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed form (human)
hALAS1/TransPep-

organism-modification


PR:000046305 5-aminolevulinate synthase, non-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing form (human)
hALAS1/TransPep-/PyrdoxLys+

gene


PR:000003917 5-aminolevulinate synthase, erythroid-specific, mitochondrial
ALAS2

organism-gene


PR:O14092 5-aminolevulinate synthase, mitochondrial (Schizosaccharomyces pombe 972h-)
Spom972h-ALAS2

organism-gene


PR:P08680 5-aminolevulinate synthase, erythroid-specific, mitochondrial (mouse)
mALAS2

organism-sequence


PR:P08680-1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (mouse)
mALAS2/iso:1

organism-gene


PR:P09950 5-aminolevulinate synthase, mitochondrial (yeast)
yALAS2

organism-gene


PR:P22557 5-aminolevulinate synthase, erythroid-specific, mitochondrial (human)
hALAS2

organism-sequence


PR:P22557-1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (human)
hALAS2/iso:1

organism-sequence


PR:P22557-2 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform h2 (human)
hALAS2/iso:h2

organism-sequence


PR:P22557-3 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform h3 (human)
hALAS2/iso:h3

organism-sequence


PR:P22557-4 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform h4 (human)
hALAS2/iso:h4

organism-modification


PR:000046306 5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing form (human)
hALAS2/TransPep-/PyrdoxLys+

organism-modification


PR:000085991 5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing 1 (human)
hALAS2/TransPep-/Pyrdox:1

organism-gene


PR:Q54UX3 5-aminolevulinate synthase (Dictyostelium discoideum)
Dicty-ALAS2

organism-gene


PR:Q63147 5-aminolevulinate synthase, erythroid-specific, mitochondrial (rat)
rALAS2

organism-sequence


PR:Q63147-1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (rat)
rALAS2/iso:1

organism-gene


PR:Q9YHT4 5-aminolevulinate synthase, erythroid-specific, mitochondrial (zebrafish)
z-ALAS2

sequence


PR:000039074 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1
ALAS2/iso:1

organism-sequence


PR:P08680-1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (mouse)
mALAS2/iso:1

organism-sequence


PR:P22557-1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (human)
hALAS2/iso:1

organism-sequence


PR:Q63147-1 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform 1 (rat)
rALAS2/iso:1

modification


PR:000018947 5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed form
ALAS2/TransPep-

organism-modification


PR:000046306 5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing form (human)
hALAS2/TransPep-/PyrdoxLys+

organism-modification


PR:000085991 5-aminolevulinate synthase, erythroid-specific, mitochondrial, transit peptide removed pyridoxal phosphate lysine-containing 1 (human)
hALAS2/TransPep-/Pyrdox:1

family


PR:000026126 eukaryotic serine palmitoyltransferase
fam:euk-SPT

gene


PR:000015596 serine palmitoyltransferase 1
SPTLC1

organism-gene


PR:D4A2H2 serine palmitoyltransferase 1 (rat)
rSPTLC1

organism-gene


PR:O15269 serine palmitoyltransferase 1 (human)
hSPTLC1

Yes
organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human)
hSPTLC1/iso:1

organism-sequence


PR:O15269-2 serine palmitoyltransferase 1 isoform h2 (human)
hSPTLC1/iso:h2

organism-modification


PR:000045580 serine palmitoyltransferase 1 phosphorylated 1 (human)
hSPTLC1/Phos:1

organism-modification


PR:000061744 serine palmitoyltransferase 1 pyridoxal phosphate lysine-containing form (human)
hSPTLC1/PyrdoxLys+

organism-modification


PR:000075626 serine palmitoyltransferase 1 cysteinylated 1 (human)
hSPTLC1/Cyst:1

organism-modification


PR:000078051 serine palmitoyltransferase 1 methylated 1 (human)
hSPTLC1/Me:1

organism-gene


PR:O35704 serine palmitoyltransferase 1 (mouse)
mSPTLC1
Yes
Yes
organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse)
mSPTLC1/iso:1
Yes
organism-gene


PR:O59682 serine palmitoyltransferase 1 (Schizosaccharomyces pombe 972h-)
Spom972h-SPTLC1

organism-gene


PR:P25045 serine palmitoyltransferase 1 (yeast)
ySPTLC1

organism-gene


PR:P91079 serine palmitoyltransferase 1 (worm)
SPTLC1 (worm)

organism-gene


PR:Q55FL5 serine palmitoyltransferase 1 (Dictyostelium discoideum)
Dicty-SPTLC1

organism-gene


PR:Q94IB8 long chain base biosynthesis protein 1 (Arabidopsis thaliana)
At-SPTLC1

sequence


PR:000022019 serine palmitoyltransferase 1 isoform 1
SPTLC1/iso:1

organism-sequence


PR:O15269-1 serine palmitoyltransferase 1 isoform 1 (human)
hSPTLC1/iso:1

organism-sequence


PR:O35704-1 serine palmitoyltransferase 1 isoform 1 (mouse)
mSPTLC1/iso:1
Yes
gene


PR:000015597 serine palmitoyltransferase 2
SPTLC2

organism-gene


PR:O15270 serine palmitoyltransferase 2 (human)
hSPTLC2

Yes
organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human)
hSPTLC2/iso:1

organism-modification


PR:000049342 serine palmitoyltransferase 2 pyridoxal phosphate lysine-containing 1 (human)
hSPTLC2/Pyrdox:1

organism-modification


PR:000073274 serine palmitoyltransferase 2 methylated 1 (human)
hSPTLC2/Me:1

organism-modification


PR:000083083 serine palmitoyltransferase 2 methylated 2 (human)
hSPTLC2/Me:2

organism-gene


PR:P97363 serine palmitoyltransferase 2 (mouse)
mSPTLC2
Yes
Yes
organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse)
mSPTLC2/iso:1
Yes
organism-gene


PR:Q3B7D2 serine palmitoyltransferase 2 (rat)
rSPTLC2

sequence


PR:000022020 serine palmitoyltransferase 2 isoform 1
SPTLC2/iso:1

organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human)
hSPTLC2/iso:1

organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse)
mSPTLC2/iso:1
Yes
gene


PR:000015598 serine palmitoyltransferase 3
SPTLC3

organism-gene


PR:Q8BG54 serine palmitoyltransferase 3 (mouse)
mSPTLC3

Yes
organism-gene


PR:Q9NUV7 serine palmitoyltransferase 3 (human)
hSPTLC3

Yes
organism-sequence


PR:Q9NUV7-1 serine palmitoyltransferase 3 isoform h1 (human)
hSPTLC3/iso:h1

organism-sequence


PR:Q9NUV7-2 serine palmitoyltransferase 3 isoform h2 (human)
hSPTLC3/iso:h2

organism-modification


PR:000049343 serine palmitoyltransferase 3 pyridoxal phosphate lysine-containing 1 (human)
hSPTLC3/Pyrdox:1

gene


PR:000026127 bacterial-type serine palmitoyltransferase
spt1

organism-gene


PR:A5VD79 serine palmitoyltransferase (Rhizorhabdus wittichii RW1)
spt1 (RHIWR)

organism-sequence


PR:A5VD79-1 bacterial-type serine palmitoyltransferase isoform 1 (Rhizorhabdus wittichii RW1)
spt1/iso:1 (RHIWR)

Yes
organism-gene


PR:A7BFV6 serine palmitoyltransferase (Sphingobacterium multivorum)
spt1 (SPHMU)

organism-sequence


PR:A7BFV6-1 serine palmitoyltransferase isoform 1 (Sphingobacterium multivorum)
spt1/iso:1 (SPHMU)

Yes
organism-gene


PR:Q93UV0 serine palmitoyltransferase (Sphingomonas paucimobilis)
spt1 (SPHPI)

organism-sequence


PR:Q93UV0-1 bacterial-type serine palmitoyltransferase isoform 1 (Sphingomonas paucimobilis)
spt1/iso:1 (SPHPI)

Yes
sequence


PR:000026128 bacterial-type serine palmitoyltransferase isoform 1
spt1/iso:1

organism-sequence


PR:A5VD79-1 bacterial-type serine palmitoyltransferase isoform 1 (Rhizorhabdus wittichii RW1)
spt1/iso:1 (RHIWR)

Yes
organism-sequence


PR:A7BFV6-1 serine palmitoyltransferase isoform 1 (Sphingobacterium multivorum)
spt1/iso:1 (SPHMU)

Yes
organism-sequence


PR:Q93UV0-1 bacterial-type serine palmitoyltransferase isoform 1 (Sphingomonas paucimobilis)
spt1/iso:1 (SPHPI)

Yes
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hMCCC2/var:MCCB IVS3+5G->T forms found in complexes   

hMCCC2/var:MCCB IVS3+5G->T Component
 Complexes
PR:A5VD79ZDASHZ1 spt1/iso:1 (RHIWR) PR:000026132 bacterial-type serine palmitoyltransferase complex (Rhizorhabdus wittichii RW1)
PR:A7BFV6ZDASHZ1 spt1/iso:1 (SPHMU) PR:000026169 bacterial-type serine palmitoyltransferase complex (Sphingobacterium multivorum)
PR:O15269 hSPTLC1 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O15270 hSPTLC2 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:O35704 mSPTLC1 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:P97363 mSPTLC2 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:Q8BG54 mSPTLC3 PR:000025762 serine palmitoyltransferase complex A (mouse)
PR:Q93UV0ZDASHZ1 spt1/iso:1 (SPHPI) PR:000026130 bacterial-type serine palmitoyltransferase complex (Sphingomonas paucimobilis)
PR:Q9NUV7 hSPTLC3 PR:000026145 serine palmitoyltransferase complex core 2 (human)
PR:000026146 serine palmitoyltransferase complex 3 (human)
PR:000026152 serine palmitoyltransferase complex 4 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:O35704 mSPTLC1 acts_upstream_of_or_withinGO:0006686 sphingomyelin biosynthetic process PMID:16216550
GO:0046511 sphinganine biosynthetic process PMID:19416652
GO:0046512 sphingosine biosynthetic process PMID:16216550
GO:0046513 ceramide biosynthetic process PMID:16216550
PR:O35704-1 mSPTLC1/iso:1 enablesNOT GO:0004758 serine C-palmitoyltransferase activity PMID:9363775
GO:0005515 protein binding PMID:18484747
PR:P97363 mSPTLC2 acts_upstream_of_or_withinGO:0006686 sphingomyelin biosynthetic process PMID:16216550
GO:0046512 sphingosine biosynthetic process PMID:16216550
GO:0046513 ceramide biosynthetic process PMID:16216550
PR:P97363-1 mSPTLC2/iso:1 acts_upstream_of_or_withinGO:0046511 sphinganine biosynthetic process PMID:9363775
enablesGO:0004758 serine C-palmitoyltransferase activity PMID:9363775
located_inGO:0005739 mitochondrion PMID:18614015