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Protein Ontology report - methyl-CpG-binding protein 2 isoform 2
PR:000026059 - http://purl.obolibrary.org/obo/PR_000026059
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000026059   
  PRO namemethyl-CpG-binding protein 2 isoform 2 
  Synonyms
PRO-Short-label: EXACT:MECP2/iso:2
Other: EXACT:methyl-CpG-binding protein 2 isoform B
  Definition"A methyl-CpG-binding protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2D6-2 or a 1:1 ortholog thereof." [PMID:16141072, PRO:CNA] 
  PRO Categorysequence 
  ParentPR:000010277 methyl-CpG-binding protein 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 14                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000026059

methyl-CpG-binding protein 2 isoform 2

MECP2/iso:2


"A methyl-CpG-binding protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2D6-2 or a 1:1 ortholog thereof." [PMID:16141072, PRO:CNA]


organism-sequence



PR:P51608-2

methyl-CpG-binding protein 2 isoform 2 (human)

hMECP2/iso:2


"A methyl-CpG-binding protein 2 isoform 2 that is encoded in the genome of human." [PMID:15034579, PRO:CNA]


organism-sequence



PR:000060337

methyl-CpG-binding protein 2 isoform 2 sequence variant T170A (human)

hMECP2/iso:2/var:T170A


"A methyl-CpG-binding protein 2 isoform 2 (human) that has an Ala residue at the position equivalent to Thr-170 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Thr-170, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-9023413]


organism-sequence



PR:000060596

methyl-CpG-binding protein 2 isoform 2 sequence variant D133G (human)

hMECP2/iso:2/var:D133G


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a Gly residue at the position equivalent to Asp-133 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Asp-133, CHEBI:29947." [PRO:DNx, Reactome:R-HSA-9022499]


organism-sequence



PR:000060611

methyl-CpG-binding protein 2 isoform 2 sequence variant R318C (human)

hMECP2/iso:2/var:R318C


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a Cys residue at the position equivalent to Arg-318 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Arg-318, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-9005577]


organism-sequence



PR:000060861

methyl-CpG-binding protein 2 isoform 2 sequence variant T170M (human)

hMECP2/iso:2/var:T170M


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a Met residue at the position equivalent to Thr-170 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Thr-170, CHEBI:16044." [PRO:DNx, Reactome:R-HSA-9023409]


organism-sequence



PR:000061108

methyl-CpG-binding protein 2 isoform 2 sequence variant K317R (human)

hMECP2/iso:2/var:K317R


"A methyl-CpG-binding protein 2 isoform 2 (human) that has an Arg residue at the position equivalent to Lys-317 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Lys-317, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9005541]


organism-sequence



PR:000061395

methyl-CpG-binding protein 2 isoform 2 sequence variant R118W (human)

hMECP2/iso:2/var:R118W


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a Trp residue at the position equivalent to Arg-118 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Arg-118, CHEBI:29954." [PRO:DNx, Reactome:R-HSA-9023451]


organism-sequence



PR:000061996

methyl-CpG-binding protein 2 isoform 2 sequence variant K316E (human)

hMECP2/iso:2/var:K316E


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a Glu residue at the position equivalent to Lys-316 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Lys-316, CHEBI:29972." [PRO:DNx, Reactome:R-HSA-9005586]


organism-sequence



PR:000062182

methyl-CpG-binding protein 2 isoform 2 sequence variant P314R (human)

hMECP2/iso:2/var:P314R


"A methyl-CpG-binding protein 2 isoform 2 (human) that has an Arg residue at the position equivalent to Pro-314 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Pro-314, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-9005574]


organism-sequence



PR:000063480

methyl-CpG-binding protein 2 isoform 2 sequence variant R145H (human)

hMECP2/iso:2/var:R145H


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a His residue at the position equivalent to Arg-145 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Arg-145, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-9022479]


organism-sequence



PR:000063514

methyl-CpG-binding protein 2 isoform 2 sequence variant R318H (human)

hMECP2/iso:2/var:R318H


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a His residue at the position equivalent to Arg-318 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Arg-318, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-9005568]


organism-sequence



PR:000063613

methyl-CpG-binding protein 2 isoform 2 sequence variant R145C (human)

hMECP2/iso:2/var:R145C


"A methyl-CpG-binding protein 2 isoform 2 (human) that has a Cys residue at the position equivalent to Arg-145 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Arg-145, CHEBI:29950." [PRO:DNx, Reactome:R-HSA-9022489]


organism-modification



PR:000060981

methyl-CpG-binding protein 2 isoform 2 phosphorylated 1 (human)

hMECP2/iso:2/Phos:1


"A methyl-CpG-binding protein 2 isoform 2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-320 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Thr-320, MOD:00047." [PRO:DNx, Reactome:R-HSA-9005592]


organism-modification



PR:000062502

methyl-CpG-binding protein 2 isoform 2 phosphorylated 2 (human)

hMECP2/iso:2/Phos:2


"A methyl-CpG-binding protein 2 isoform 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-435 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Ser-435, MOD:00046." [PRO:DNx, Reactome:R-HSA-9007001]


organism-modification



PR:000063773

methyl-CpG-binding protein 2 isoform 2 phosphorylated 3 (human)

hMECP2/iso:2/Phos:3


"A methyl-CpG-binding protein 2 isoform 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-92 of the amino acid sequence represented by UniProtKB:P51608-2. UniProtKB:P51608-2, Ser-92, MOD:00046." [PRO:DNx, Reactome:R-HSA-9022333]


organism-sequence



PR:Q00566-2

methyl-CpG-binding protein 2 isoform 2 (rat)

rMECP2/iso:2


"A methyl-CpG-binding protein 2 isoform 2 that is encoded in the genome of rat." [PRO:CNA]


organism-sequence



PR:Q9Z2D6-2

methyl-CpG-binding protein 2 isoform 2 (mouse)

mMECP2/iso:2


"A methyl-CpG-binding protein 2 isoform 2 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9Z2D6-2 mMECP2/iso:2 enablesGO:0003682 chromatin binding MGI_ref:3805223; PMID:18334558
located_inGO:0000792 heterochromatin MGI_ref:3805223; PMID:18334558
GO:0005634 nucleus MGI_ref:3805223; PMID:18334558
GO:0005634 nucleus MGI_ref:3805223; PMID:18334558