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RACE-PRO
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Protein Ontology report - smad4 isoform 1 monoubiquitinated 2
PR:000025957 -
http://purl.obolibrary.org/obo/PR_000025957
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000025957
PRO name
smad4 isoform 1 monoubiquitinated 2
Synonyms
PRO-Short-label
:
EXACT:
SMAD4/iso:1/MonoUbiq:2
Other
:
RELATED:
mono-ubiquitinated smad4
Definition
"A smad4 isoform 1 that has been monoubiquitinated on a lysine residue within the MH2 domain by E3 ubiquitin-protein ligase TRIM33. Example:
UniProtKB:Q13485-1
, Lys-519,
MOD:01148
." [
PMID:18783722
]
PRO Category
modification
Parent
PR:000000366
smad4 isoform 1
PR:000037077
ubiquitinated protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000025957
smad4 isoform 1 monoubiquitinated 2
SMAD4/iso:1/MonoUbiq:2
"A smad4 isoform 1 that has been monoubiquitinated on a lysine residue within the MH2 domain by E3 ubiquitin-protein ligase TRIM33. Example: UniProtKB:Q13485-1, Lys-519, MOD:01148." [PMID:18783722]
organism-modification
PR:000025958
mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
hSMAD4/iso:1/MonoUbiq:2
"A smad4 isoform 1 monoubiquitinated 2 in human. UniProtKB:Q13485-1, Lys-519, MOD:01148." [PMID:19135894]
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025958
hSMAD4/iso:1/MonoUbiq:2
UniProtKB:Q13485-1, Lys-519, MOD:01148
acts_upstream_of_or_within
GO:0030512
negative regulation of transforming growth factor beta receptor signaling pathway
PMID:19135894
enables
NOT
GO:0046332
SMAD binding
PMID:19135894
