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Protein Ontology report - mediator of RNA polymerase II transcription subunit 28 isoform 1
PR:000025609 - http://purl.obolibrary.org/obo/PR_000025609
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000025609   
  PRO namemediator of RNA polymerase II transcription subunit 28 isoform 1 
  Synonyms
PRO-Short-label: EXACT:MED28/iso:1
  Definition"A mediator of RNA polymerase II transcription subunit 28 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H204-1 or a 1:1 ortholog thereof." [PRO:JAN] 
  PRO Categorysequence 
  ParentPR:000010300 mediator of RNA polymerase II transcription subunit 28
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000025609
mediator of RNA polymerase II transcription subunit 28 isoform 1
MED28/iso:1
"A mediator of RNA polymerase II transcription subunit 28 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H204-1 or a 1:1 ortholog thereof." [PRO:JAN]

organism-sequence


PR:Q920D3-1
mediator of RNA polymerase II transcription subunit 28 isoform 1 (mouse)
mMED28/iso:1
"A mediator of RNA polymerase II transcription subunit 28 isoform 1 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]
Yes
Yes
organism-sequence


PR:Q9H204-1
mediator of RNA polymerase II transcription subunit 28 isoform 1 (human)
hMED28/iso:1
"A mediator of RNA polymerase II transcription subunit 28 isoform 1 that is encoded in the genome of human." [PRO:JAN]

organism-modification


PR:000025633
mediator of RNA polymerase II transcription subunit 28 isoform 1 phosphorylated 1 (human)
hMED28/iso:1/Phos:1
"A mediator of RNA polymerase II transcription subunit 28 isoform 1 phosphorylated 1 in human. UniProtKB:Q9H204-1, Tyr-64, MOD:00048." [PMID:16899217, PRO:JAN]
Yes
modification


PR:000025611
mediator of RNA polymerase II transcription subunit 28 isoform 1 phosphorylated 1
MED28/iso:1/Phos:1
"A mediator of RNA polymerase II transcription subunit 28 isoform 1 that has been phosphorylated by Src-family kinases upon CD3 stimulation. Example: UniProtKB:Q9H204-1, Tyr-64, MOD:00048." [PMID:16899217, PRO:JAN]

organism-modification


PR:000025633
mediator of RNA polymerase II transcription subunit 28 isoform 1 phosphorylated 1 (human)
hMED28/iso:1/Phos:1
"A mediator of RNA polymerase II transcription subunit 28 isoform 1 phosphorylated 1 in human. UniProtKB:Q9H204-1, Tyr-64, MOD:00048." [PMID:16899217, PRO:JAN]
Yes
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MED28/iso:1 forms found in complexes   

MED28/iso:1 Component
 Complexes
PR:Q920D3ZDASHZ1 mMED28/iso:1 PR:000028902 mediator complex, MED26-containing (mouse)
PR:000028957 mediator complex, CDK8-containing (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025633 hMED28/iso:1/Phos:1
UniProtKB:Q9H204-1, Tyr-64, MOD:00048		 enablesGO:0005515 protein binding with PR:P62993 adapter protein GRB2 (human) PMID:16899217
PR:Q920D3-1 mMED28/iso:1 located_inGO:0016592 mediator complex MGI_ref:4462751; PMID:20508642