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Protein Ontology report - TGF-beta 1 isoform 1, signal peptide removed form
PR:000025454 -
http://purl.obolibrary.org/obo/PR_000025454
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000025454
PRO name
TGF-beta 1 isoform 1, signal peptide removed form
Synonyms
PRO-Short-label
:
EXACT:
TGFB1/iso:1/SigPep-
Definition
"A TGF-beta 1 isoform 1 that has had the signal peptide removed." [PRO:DAN]
PRO Category
modification
Parent
PR:000000397
TGF-beta 1 isoform 1
PR:000018291
TGF-beta 1, signal peptide removed form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
3
Organism-Modification
4
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000025454
TGF-beta 1 isoform 1, signal peptide removed form
TGFB1/iso:1/SigPep-
"A TGF-beta 1 isoform 1 that has had the signal peptide removed." [PRO:DAN]
modification
PR:000000617
TGF-beta 1 isoform 1 latency associated peptide
TGFB1/iso:1/LAP
"A TGF-beta 1 isoform 1, signal peptide removed form that has had the C-terminal mature peptide removed and has been N-glycosylated mainly at either one of the two first consensus N-glycosylation sites. Example: UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:3162913, PRO:CNA, PRO:DAN]
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]
Yes
modification
PR:000000618
TGF-beta 1 isoform 1 inactive form
TGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example: UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:3162913, PMID:3185545, PRO:CNA, PRO:DAN]
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]
Yes
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000026335
hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3162913
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:2677679
;
PMID:3162913
GO:0042803
protein homodimerization activity
PMID:3162913
located_in
GO:0031012
extracellular matrix
PMID:17015622
;
PMID:8294500
GO:0032991
protein-containing complex
PMID:3162913
PR:000036526
hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160
located_in
GO:0032991
protein-containing complex
PMID:17015622
;
PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:1448117
;
PMID:2677679
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:1448117
located_in
GO:0032991
protein-containing complex
PMID:1448117
;
PMID:2677679
PR:000036529
mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856
located_in
GO:0031012
extracellular matrix
PMID:9008713
