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Documentation
Protein Ontology report - type II interferon
PR:000024990 -
http://purl.obolibrary.org/obo/PR_000024990
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000024990
PRO name
type II interferon
Synonyms
Other
:
EXACT:
IFN type II | interferon type II
RELATED:
interferon gamma
Definition
"A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains." [
PMID:9607096
, PRO:DAN, PRO:MSY]
Comment
Note: Some references consider 'gamma' and 'type II' to be synonyms. This is likely because gamma is the only type II interferon identified. However, the classification criteria for each nomenclature system differ.
PRO Category
family
Parent
PR:000000001
protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
1
Organism-Family
0
Gene
1
Organism-Gene
4
Sequence
1
Organism-Sequence
2
Modification
5
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
family
PR:000024990
type II interferon
rpsA/iso:1/Ac:1
"A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains." [PMID:9607096, PRO:DAN, PRO:MSY]
gene
PR:000000017
interferon gamma
IFNG
"A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions." [PRO:CNA]
Yes
organism-gene
PR:P01579
interferon gamma (human)
hIFNG
"An interferon gamma that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01579]
organism-sequence
PR:P01579-1
interferon gamma isoform 1 (human)
hIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-modification
PR:000068116
interferon gamma, mature form (human)
hIFNG/mature
"An interferon gamma (human) that has had the signal peptide and propeptide removed. UniProtKB:P01579, 24-161." [PRO:DNx, Reactome:R-HSA-629621]
organism-gene
PR:P01580
interferon gamma (mouse)
mIFNG
"An interferon gamma that is encoded in the genome of mouse." [OMA:P01580, PRO:DNx]
organism-sequence
PR:P01580-1
interferon gamma isoform 1 (mouse)
mIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-gene
PR:P01581
interferon gamma (rat)
rIFNG
"An interferon gamma that is encoded in the genome of rat." [OMA:P01581, PRO:DNx]
organism-gene
PR:P49708
interferon gamma (chicken)
chick-IFNG
"An interferon gamma that is encoded in the genome of chicken." [OMA:P49708, PRO:DNx]
sequence
PR:000000100
interferon gamma isoform 1
IFNG/iso:1
"An interferon gamma that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01579-1 or a 1:1 ortholog thereof." [PRO:CNA]
organism-sequence
PR:P01579-1
interferon gamma isoform 1 (human)
hIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-sequence
PR:P01580-1
interferon gamma isoform 1 (mouse)
mIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
modification
PR:000000445
interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-
"An interferon gamma isoform 1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000446
interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PMID:3109913, PRO:CNA]
modification
PR:000000447
interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1, signal peptide removed glycosylated form that is a mature protein with N-linked glycosylation and partial proteolytic degradation of the C-terminus. Example: UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PRO:CNA, PRO:DAN]
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
modification
PR:000018270
interferon gamma, signal peptide removed form
IFNG/SigPep-
"An interferon gamma that has had the signal peptide removed." [PRO:DNx]
modification
PR:000000445
interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-
"An interferon gamma isoform 1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000446
interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PMID:3109913, PRO:CNA]
modification
PR:000000447
interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1, signal peptide removed glycosylated form that is a mature protein with N-linked glycosylation and partial proteolytic degradation of the C-terminus. Example: UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PRO:CNA, PRO:DAN]
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-modification
PR:000068116
interferon gamma, mature form (human)
hIFNG/mature
"An interferon gamma (human) that has had the signal peptide and propeptide removed. UniProtKB:P01579, 24-161." [PRO:DNx, Reactome:R-HSA-629621]
modification
PR:000018271
interferon gamma proteolytic cleavage product
IFNG/ClvPrd
"An interferon gamma that has been processed by proteolytic cleavage." [PRO:DNx]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000017
IFNG
It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions
acts_upstream_of_or_within
GO:0006955
immune response
PIRSF:PIRSF001936
GO:0032722
positive regulation of chemokine production
PIRSF:PIRSF001936
PR:000036407
mIFNG/iso:1/SigPep-/GlycoRes+
UniProtKB:P01580-1, 23-155, MOD:00693
acts_upstream_of_or_within
GO:0050776
regulation of immune response
PMID:12882831
enables
GO:0005125
cytokine activity
PMID:11027433
;
PMID:12925700
;
PMID:15240719
located_in
GO:0005615
extracellular space
PMID:11057672
;
PMID:11728336
;
PMID:15240714
PR:000036418
mIFNG/iso:1/SigPep-
UniProtKB:P01580-1, 23-155
acts_upstream_of_or_within
GO:0050776
regulation of immune response
PMID:11441112
enables
GO:0005125
cytokine activity
PMID:11441112
PR:000036419
hIFNG/iso:1/SigPep-/NGlyco:1
UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160
enables
GO:0005133
type II interferon receptor binding
PMID:10986460
GO:0042803
protein homodimerization activity
PMID:3109913
located_in
GO:0005615
extracellular space
PMID:6427223
PR:000036420
hIFNG/iso:1/ClvNGlyco:2
UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160
enables
GO:0042803
protein homodimerization activity
PMID:1902591
PR:P01580-1
mIFNG/iso:1
acts_upstream_of_or_within
GO:0032722
positive regulation of chemokine production
PMID:12925700
GO:0042742
defense response to bacterium
PMID:17661079
