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Protein Ontology report - type II interferon
PR:000024990 - http://purl.obolibrary.org/obo/PR_000024990
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000024990   
  PRO nametype II interferon 
  Synonyms
Other: EXACT:IFN type II | interferon type II
RELATED:interferon gamma
  Definition"A protein that binds to a specific cell surface receptor complex known as the IFN-gamma receptor (IFNGR), a complex of two IFNGR1 and two IFNGR2 chains." [PMID:9607096, PRO:DAN, PRO:MSY] 
  CommentNote: Some references consider 'gamma' and 'type II' to be synonyms. This is likely because gamma is the only type II interferon identified. However, the classification criteria for each nomenclature system differ. 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000024990 type II interferon
rpsA/iso:1/Ac:1

gene


PR:000000017 interferon gamma
IFNG
Yes
organism-gene


PR:P01579 interferon gamma (human)
hIFNG

organism-sequence


PR:P01579-1 interferon gamma isoform 1 (human)
hIFNG/iso:1

organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000068116 interferon gamma, mature form (human)
hIFNG/mature

organism-gene


PR:P01580 interferon gamma (mouse)
mIFNG

organism-sequence


PR:P01580-1 interferon gamma isoform 1 (mouse)
mIFNG/iso:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-gene


PR:P01581 interferon gamma (rat)
rIFNG

organism-gene


PR:P49708 interferon gamma (chicken)
chick-IFNG

sequence


PR:000000100 interferon gamma isoform 1
IFNG/iso:1

organism-sequence


PR:P01579-1 interferon gamma isoform 1 (human)
hIFNG/iso:1

organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-sequence


PR:P01580-1 interferon gamma isoform 1 (mouse)
mIFNG/iso:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
modification


PR:000000445 interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-

modification


PR:000000446 interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+

modification


PR:000000447 interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2

organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
modification


PR:000018270 interferon gamma, signal peptide removed form
IFNG/SigPep-

modification


PR:000000445 interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-

modification


PR:000000446 interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+

modification


PR:000000447 interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2

organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000068116 interferon gamma, mature form (human)
hIFNG/mature

modification


PR:000018271 interferon gamma proteolytic cleavage product
IFNG/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000017 IFNG
It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions		 acts_upstream_of_or_withinGO:0006955 immune response PIRSF:PIRSF001936
GO:0032722 positive regulation of chemokine production PIRSF:PIRSF001936
PR:000036407 mIFNG/iso:1/SigPep-/GlycoRes+
UniProtKB:P01580-1, 23-155, MOD:00693		 acts_upstream_of_or_withinGO:0050776 regulation of immune response PMID:12882831
enablesGO:0005125 cytokine activity PMID:11027433; PMID:12925700; PMID:15240719
located_inGO:0005615 extracellular space PMID:11057672; PMID:11728336; PMID:15240714
PR:000036418 mIFNG/iso:1/SigPep-
UniProtKB:P01580-1, 23-155		 acts_upstream_of_or_withinGO:0050776 regulation of immune response PMID:11441112
enablesGO:0005125 cytokine activity PMID:11441112
PR:000036419 hIFNG/iso:1/SigPep-/NGlyco:1
UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160		 enablesGO:0005133 type II interferon receptor binding PMID:10986460
GO:0042803 protein homodimerization activity PMID:3109913
located_inGO:0005615 extracellular space PMID:6427223
PR:000036420 hIFNG/iso:1/ClvNGlyco:2
UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160		 enablesGO:0042803 protein homodimerization activity PMID:1902591
PR:P01580-1 mIFNG/iso:1 acts_upstream_of_or_withinGO:0032722 positive regulation of chemokine production PMID:12925700
GO:0042742 defense response to bacterium PMID:17661079