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Protein Ontology report - isocitrate dehydrogenase [NADP]
PR:000022989 - http://purl.obolibrary.org/obo/PR_000022989
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000022989   
  PRO nameisocitrate dehydrogenase [NADP] 
  Synonyms
PRO-Short-label: EXACT:icd
Other: EXACT:IDH | IDP | NADP(+)-specific ICDH | oxalosuccinate decarboxylase
RELATED:icdA | icdE
  Definition"A metal-dependent decarboxylating R-hydroxyacid dehydrogenase that is a translation product of the Escherichia coli K-12 icd gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000026156 metal-dependent decarboxylating R-hydroxyacid dehydrogenase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 1                                        
         Sequence1                                                  Organism-Sequence 1                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000022989
isocitrate dehydrogenase [NADP]
icd
"A metal-dependent decarboxylating R-hydroxyacid dehydrogenase that is a translation product of the Escherichia coli K-12 icd gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P08200
isocitrate dehydrogenase [NADP] (Escherichia coli K-12)
Ec-icd
"An isocitrate dehydrogenase [NADP] that is encoded in the genome of Escherichia coli K-12." [PRO:CNA]

organism-sequence


PR:P08200-1
isocitrate dehydrogenase [NADP] isoform 1 (Escherichia coli K-12)
Ec-icd/iso:1
"An isocitrate dehydrogenase [NADP] isoform 1 that is encoded in the genome of Escherichia coli K-12." [PRO:DNx, UniProtKB:P08200]

organism-modification


PR:000036730
isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Ac:1
"An isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 in Escherichia coli K-12. UniProtKB:P08200-1, Lys-142, MOD:00064." [EcoCyc:ISOCITDEH-SUBUNIT, PRO:CNA]

organism-modification


PR:000036731
isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Phos:1
"An isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 in Escherichia coli K-12. UniProtKB:P08200-1, Ser-113, MOD:00046." [EcoCyc:ISOCITHASE-P, PRO:CNA]
Yes
sequence


PR:000025138
isocitrate dehydrogenase [NADP] isoform 1
icd/iso:1
"An isocitrate dehydrogenase [NADP] that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08200-1 or a 1:1 ortholog thereof." [EcoCyc:ISOCITDEH-SUBUNIT]

organism-sequence


PR:P08200-1
isocitrate dehydrogenase [NADP] isoform 1 (Escherichia coli K-12)
Ec-icd/iso:1
"An isocitrate dehydrogenase [NADP] isoform 1 that is encoded in the genome of Escherichia coli K-12." [PRO:DNx, UniProtKB:P08200]

organism-modification


PR:000036730
isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Ac:1
"An isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 in Escherichia coli K-12. UniProtKB:P08200-1, Lys-142, MOD:00064." [EcoCyc:ISOCITDEH-SUBUNIT, PRO:CNA]

organism-modification


PR:000036731
isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Phos:1
"An isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 in Escherichia coli K-12. UniProtKB:P08200-1, Ser-113, MOD:00046." [EcoCyc:ISOCITHASE-P, PRO:CNA]
Yes
modification


PR:000025139
isocitrate dehydrogenase [NADP] isoform 1 unmodified form
icd/iso:1/UnMod
"An isocitrate dehydrogenase [NADP] isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [EcoCyc:ISOCITDEH-SUBUNIT]

modification


PR:000025140
isocitrate dehydrogenase [NADP] isoform 1 acetylated 1
icd/iso:1/Ac:1
"An isocitrate dehydrogenase [NADP] isoform 1 that has been acetylated at the position equivalent to Lys-142 of the amino acid sequence represented by UniProtKB:P08200-1. Example: UniProtKB:P08200-1, Lys-142, MOD:00064." [EcoCyc:ISOCITDEH-SUBUNIT]

organism-modification


PR:000036730
isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Ac:1
"An isocitrate dehydrogenase [NADP] isoform 1 acetylated 1 in Escherichia coli K-12. UniProtKB:P08200-1, Lys-142, MOD:00064." [EcoCyc:ISOCITDEH-SUBUNIT, PRO:CNA]

modification


PR:000025141
isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1
icd/iso:1/Phos:1
"An isocitrate dehydrogenase [NADP] isoform 1 that has been phosphorylated by aceK on a Ser residue involved in substrate binding, leading to inactivation of isocitrate dehydrogenase. Example: UniProtKB:P08200-1, Ser-113, MOD:00046." [EcoCyc:ISOCITHASE-P, PMID:3112144]

organism-modification


PR:000036731
isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 (Escherichia coli K-12)
Ec-icd/iso:1/Phos:1
"An isocitrate dehydrogenase [NADP] isoform 1 phosphorylated 1 in Escherichia coli K-12. UniProtKB:P08200-1, Ser-113, MOD:00046." [EcoCyc:ISOCITHASE-P, PRO:CNA]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036731 Ec-icd/iso:1/Phos:1
UniProtKB:P08200-1, Ser-113, MOD:00046		 acts_upstream_of_or_withinGO:0006099 tricarboxylic acid cycle EcoCyc:ISOCITHASE-P