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Protein Ontology report - vertebrate-like neuraminidase
PR:000022007 - http://purl.obolibrary.org/obo/PR_000022007
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000022007   
  PRO namevertebrate-like neuraminidase 
  Synonyms
Other: sialidase (BROAD)
  Definition"A protein that is a glycohydrolytic enzyme, which removes sialic acid residues from a variety of sialoglycoconjugates. Sialidases have highly conserved active site residues, the F/YRIV/P motif in the N-terminal part and the Asp boxes (consensus S/TXD(x)GxTW/F present as three to five repeat in the protein) similar to their viral and bacterial counter parts." [PMID:12374200
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 11                                        
         Sequence1                                                  Organism-Sequence 9                                        
         Modification1                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000022007

vertebrate-like neuraminidase

PRG2/iso:1/EMBP


"A protein that is a glycohydrolytic enzyme, which removes sialic acid residues from a variety of sialoglycoconjugates. Sialidases have highly conserved active site residues, the F/YRIV/P motif in the N-terminal part and the Asp boxes (consensus S/TXD(x)GxTW/F present as three to five repeat in the protein) similar to their viral and bacterial counter parts." [PMID:12374200]


gene



PR:000011145

sialidase-1

NEU1


"A vertebrate-like neuraminidase that is a translation product of the human NEU1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O35657

sialidase-1 (mouse)

mNEU1


"A sialidase-1 that is encoded in the genome of mouse." [OMA:O35657, PRO:DNx]


organism-gene



PR:Q99519

sialidase-1 (human)

hNEU1


"A sialidase-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99519]


organism-modification



PR:000048582

sialidase-1, signal peptide removed form (human)

hNEU1/SigPep-


"A sialidase-1 (human) that has had the signal peptide removed. UniProtKB:Q99519, 48-415." [PRO:DNx, Reactome:R-HSA-1605788]


organism-modification



PR:000064272

sialidase-1 sequence variant R303P, signal peptide removed form (human)

hNEU1/var:R303P/SigPep-


"A sialidase-1 (human) that has a Pro residue at the position equivalent to Arg-303 of the amino acid sequence represented by UniProtKB:Q99519 and that has had the signal peptide removed. UniProtKB:Q99519, 48-415, Arg-303, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5674182]


organism-modification



PR:000064587

sialidase-1 sequence variant R225P, signal peptide removed form (human)

hNEU1/var:R225P/SigPep-


"A sialidase-1 (human) that has a Pro residue at the position equivalent to Arg-225 of the amino acid sequence represented by UniProtKB:Q99519 and that has had the signal peptide removed. UniProtKB:Q99519, 48-415, Arg-225, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5674167]


organism-modification



PR:000072682

sialidase-1 hydroxylated 1 (human)

hNEU1/Hy:1


"A sialidase-1 (human) that has been hydroxylated on the residue at the position equivalent to Trp-240 of the amino acid sequence represented by UniProtKB:Q99519. UniProtKB:Q99519, Trp-240, MOD:01622." [IEDB_epitope:1321159, PRO:DNx]


organism-gene



PR:Q99PW3

sialidase-1 (rat)

rNEU1


"A sialidase-1 that is encoded in the genome of rat." [OMA:Q99PW3, PRO:DNx]


modification



PR:000020732

sialidase-1, signal peptide removed form

NEU1/SigPep-


"A sialidase-1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000048582

sialidase-1, signal peptide removed form (human)

hNEU1/SigPep-


"A sialidase-1 (human) that has had the signal peptide removed. UniProtKB:Q99519, 48-415." [PRO:DNx, Reactome:R-HSA-1605788]


organism-modification



PR:000064272

sialidase-1 sequence variant R303P, signal peptide removed form (human)

hNEU1/var:R303P/SigPep-


"A sialidase-1 (human) that has a Pro residue at the position equivalent to Arg-303 of the amino acid sequence represented by UniProtKB:Q99519 and that has had the signal peptide removed. UniProtKB:Q99519, 48-415, Arg-303, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5674182]


organism-modification



PR:000064587

sialidase-1 sequence variant R225P, signal peptide removed form (human)

hNEU1/var:R225P/SigPep-


"A sialidase-1 (human) that has a Pro residue at the position equivalent to Arg-225 of the amino acid sequence represented by UniProtKB:Q99519 and that has had the signal peptide removed. UniProtKB:Q99519, 48-415, Arg-225, CHEBI:50342." [PRO:DNx, Reactome:R-HSA-5674167]


gene



PR:000011146

sialidase-2

NEU2


"A vertebrate-like neuraminidase that is a translation product of the human NEU2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q64627

sialidase-2 (rat)

rNEU2


"A sialidase-2 that is encoded in the genome of rat." [OMA:Q64627, PRO:DNx]


organism-gene



PR:Q9JMH3

sialidase-2 (mouse)

mNEU2


"A sialidase-2 that is encoded in the genome of mouse." [OMA:Q9JMH3, PRO:DNx]


organism-gene



PR:Q9Y3R4

sialidase-2 (human)

hNEU2


"A sialidase-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y3R4]


gene



PR:000011147

sialidase-3

NEU3


"A vertebrate-like neuraminidase that is a translation product of the human NEU3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q99PW5

sialidase-3 (rat)

rNEU3


"A sialidase-3 that is encoded in the genome of rat." [OMA:Q99PW5, PRO:DNx]


organism-sequence



PR:Q99PW5-1

sialidase-3 isoform 1 (rat)

rNEU3/iso:1


"A sialidase-3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q9JMH7

sialidase-3 (mouse)

mNEU3


"A sialidase-3 that is encoded in the genome of mouse." [OMA:Q9JMH7, PRO:DNx]


organism-sequence



PR:Q9JMH7-1

sialidase-3 isoform 1 (mouse)

mNEU3/iso:1


"A sialidase-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q9UQ49

sialidase-3 (human)

hNEU3


"A sialidase-3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UQ49]


organism-sequence



PR:Q9UQ49-1

sialidase-3 isoform h1 (human)

hNEU3/iso:h1


"A sialidase-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQ49-1." [PRO:DNx, UniProtKB:Q9UQ49]


organism-sequence



PR:Q9UQ49-2

sialidase-3 isoform h2 (human)

hNEU3/iso:h2


"A sialidase-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQ49-2." [PRO:DNx, UniProtKB:Q9UQ49]


organism-modification



PR:000071989

sialidase-3 phosphorylated 1 (human)

hNEU3/Phos:1


"A sialidase-3 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-346 of the amino acid sequence represented by UniProtKB:Q9UQ49-1. Example: UniProtKB:Q9UQ49-1, Tyr-346, MOD:00048." [IEDB_epitope:2149157, PRO:DNx]


organism-modification



PR:000078640

sialidase-3 cysteinylated 1 (human)

hNEU3/Cyst:1


"A sialidase-3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-356 of the amino acid sequence represented by UniProtKB:Q9UQ49-1. Example: UniProtKB:Q9UQ49-1, Cys-356, MOD:00765." [IEDB_epitope:1055023, PRO:DNx]


organism-modification



PR:000083851

sialidase-3 cysteinylated 2 (human)

hNEU3/Cyst:2


"A sialidase-3 (human) that has been cysteinylated on the residue at the position equivalent to Cys-250 of the amino acid sequence represented by UniProtKB:Q9UQ49-1. Example: UniProtKB:Q9UQ49-1, Cys-250, MOD:00765." [IEDB_epitope:1337994, PRO:DNx]


sequence



PR:000043450

sialidase-3 isoform 1

NEU3/iso:1


"A sialidase-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JMH7-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q99PW5-1

sialidase-3 isoform 1 (rat)

rNEU3/iso:1


"A sialidase-3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9JMH7-1

sialidase-3 isoform 1 (mouse)

mNEU3/iso:1


"A sialidase-3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000011148

sialidase-4

NEU4


"A vertebrate-like neuraminidase that is a translation product of the human NEU4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q8BZL1

sialidase-4 (mouse)

mNEU4


"A sialidase-4 that is encoded in the genome of mouse." [OMA:Q8BZL1, PRO:DNx]


organism-sequence



PR:Q8BZL1-1

sialidase-4 isoform m2 (mouse)

mNEU4/iso:m2


"A sialidase-4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BZL1-1." [PRO:DNx, UniProtKB:Q8BZL1]


organism-sequence



PR:Q8BZL1-2

sialidase-4 isoform m1 (mouse)

mNEU4/iso:m1


"A sialidase-4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BZL1-2." [PRO:DNx, UniProtKB:Q8BZL1]


organism-gene



PR:Q8WWR8

sialidase-4 (human)

hNEU4


"A sialidase-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8WWR8]


organism-sequence



PR:Q8WWR8-1

sialidase-4 isoform h1 (human)

hNEU4/iso:h1


"A sialidase-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WWR8-1." [PRO:DNx, UniProtKB:Q8WWR8]


organism-sequence



PR:Q8WWR8-2

sialidase-4 isoform h2 (human)

hNEU4/iso:h2


"A sialidase-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WWR8-2." [PRO:DNx, UniProtKB:Q8WWR8]


organism-sequence



PR:Q8WWR8-3

sialidase-4 isoform h3 (human)

hNEU4/iso:h3


"A sialidase-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WWR8-3." [PRO:DNx, UniProtKB:Q8WWR8]