back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
PR:000021975 - http://purl.obolibrary.org/obo/PR_000021975
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000021975   
  PRO nameinterleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 
  Synonyms
PRO-Short-label: EXACT:IRAK1/iso:1/Phos:1
Other: EXACT:interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 2 | p-IRAK1
  Definition"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example: UniProtKB:P51617-1, Thr-209, MOD:00047." [PMID:11960013, PMID:14625308, PRO:CNA, TLR:AMM] 
  CommentRequested by=TLR. 
  PRO Categorymodification 
  ParentPR:000021971 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000021975
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1
IRAK1/iso:1/Phos:1
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example: UniProtKB:P51617-1, Thr-209, MOD:00047." [PMID:11960013, PMID:14625308, PRO:CNA, TLR:AMM]

organism-modification


PR:000027178
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (mouse)
mIRAK1/iso:1/Phos:1
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q62406-1, Thr-209, MOD:00047." [PMID:12538665, TLR:AMM]

Yes
organism-modification


PR:000027494
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 (human)
hIRAK1/iso:1/Phos:1
"An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P51617-1, Thr-209, MOD:00047." [PRO:DNx, UniProtKB:P51617]
Yes
Yes
Back to top
IRAK1/iso:1/Phos:1 forms found in complexes   

IRAK1/iso:1/Phos:1 Component
 Complexes
PR:000027178 mIRAK1/iso:1/Phos:1 PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027494 hIRAK1/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000027494 hIRAK1/iso:1/Phos:1
UniProtKB:P51617-1, Thr-209, MOD:00047		 enablesGO:0005515 protein binding with PR:Q9NWZ3 hIRAK4 PMID:11960013
GO:0016301 kinase activity PMID:11960013