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PRO ID
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| PRO name | interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 1 |
| Synonyms | | PRO-Short-label: | EXACT: | IRAK1/iso:1/Phos:1 | | Other: | EXACT: | interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 2 | p-IRAK1 |
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| Definition | "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located at the N terminus of the kinase domain. This is the first step following the activation of the TLR/IL-1 receptor complex. This phosphorylation results in a conformational change of the kinase domain. Example: UniProtKB:P51617-1, Thr-209, MOD:00047." [PMID:11960013, PMID:14625308, PRO:CNA, TLR:AMM] |
| Comment | Requested by=TLR. |
| PRO Category | modification |
| Parent | PR:000021971 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
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| Terms by PRO Category |
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms | | Modification | 1 |
Organism-Modification |
2 | | | |
Term Hierarchy
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