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Protein Ontology report - CD14 molecule, signal peptide removed form
PR:000018574 - http://purl.obolibrary.org/obo/PR_000018574
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000018574   
  PRO nameCD14 molecule, signal peptide removed form 
  Synonyms
PRO-Short-label: EXACT:CD14/SigPep-
  Definition"A CD14 molecule that has had the signal peptide removed." [PRO:DNx] 
  PRO Categorymodification 
  ParentPR:000001889 CD14 molecule
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification7                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000018574
CD14 molecule, signal peptide removed form
CD14/SigPep-
"A CD14 molecule that has had the signal peptide removed." [PRO:DNx]

modification


PR:000002146
CD14 molecule cleaved 1 soluble form
CD14/Clv:1/soluble
"A CD14 molecule, signal peptide removed form that lacks the GPI-anchor and has been processed by proteolytic cleavage to yield the N-terminal domain with extra C-terminal residues as compared to cleaved 2 form." [PMID:7519994]

organism-modification


PR:000036615
CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble
"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]
Yes
organism-modification


PR:000037469
CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble
"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]
Yes
modification


PR:000002148
CD14 molecule cleaved and GPI-anchored form
CD14/ClvPrd/anchored
"A CD14 molecule, signal peptide removed form that has been processed by proteolytic cleavage to yield the N-terminal domain that has been post-translationally modified to include a GPI-anchor." [PRO:CNA, PRO:DAN]

modification


PR:000036848
CD14 molecule cleaved 2
CD14/Clv:2
"A CD14 molecule, signal peptide removed form that lacks the propeptide. Example: UniProtKB:P08571, 20-345." [PRO:DAN]
Yes
modification


PR:000002147
CD14 molecule cleaved 2 soluble form
CD14/Clv:2/soluble
"A CD14 molecule cleaved 2 that lacks the GPI-anchor." [PMID:2779588]

Yes
organism-modification


PR:000029986
CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]

organism-modification


PR:000035703
CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]
Yes
Yes
modification


PR:000002149
CD14 molecule cleaved 2 GPI-anchored form
CD14/Clv:2/anchored
"A CD14 molecule cleaved 2 that is the mature membrane-bound form of this protein. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [PMID:3385210, PRO:CNA]

Yes
organism-modification


PR:000035702
CD14 molecule cleaved 2 GPI-anchored form (human)
hCD14/Clv:2/anchored
"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]
Yes
Yes
organism-modification


PR:000037470
CD14 molecule cleaved 2 GPI-anchored form (mouse)
mCD14/Clv:2/anchored
"A CD14 molecule cleaved 2 GPI-anchored form in mouse. UniProtKB:P10810, 16-336, Asn-336, MOD:00167." [PMID:10601848, PMID:18606699, PRO:CNA]

Yes
organism-modification


PR:000036946
CD14 molecule cleaved 2 (mouse)
mCD14/Clv:2
"A CD14 molecule cleaved 2 in mouse. This represents both the GPI-anchored and soluble forms. UniProtKB:P10810, 16-336." [PRO:DAN]

organism-modification


PR:000029986
CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]

organism-modification


PR:000037470
CD14 molecule cleaved 2 GPI-anchored form (mouse)
mCD14/Clv:2/anchored
"A CD14 molecule cleaved 2 GPI-anchored form in mouse. UniProtKB:P10810, 16-336, Asn-336, MOD:00167." [PMID:10601848, PMID:18606699, PRO:CNA]

organism-modification


PR:000037480
CD14 molecule cleaved 2 (human)
hCD14/Clv:2
"A CD14 molecule cleaved 2 in human. This represents both the GPI-anchored and soluble forms. UniProtKB:P08571, 20-345." [PRO:CNA, PRO:DAN]

Yes
organism-modification


PR:000035702
CD14 molecule cleaved 2 GPI-anchored form (human)
hCD14/Clv:2/anchored
"A CD14 molecule cleaved 2 GPI-anchored form in human. UniProtKB:P08571, 20-345, Asn-345, MOD:00167." [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]
Yes
Yes
organism-modification


PR:000035703
CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]
Yes
Yes
modification


PR:000036849
CD14 molecule cleaved and soluble form
CD14/ClvPrd/soluble
"A CD14 molecule, signal peptide removed form that has been processed by proteolytic cleavage to yield the N-terminal domain lacking a GPI-anchor." [PRO:DAN]

Yes
modification


PR:000002146
CD14 molecule cleaved 1 soluble form
CD14/Clv:1/soluble
"A CD14 molecule, signal peptide removed form that lacks the GPI-anchor and has been processed by proteolytic cleavage to yield the N-terminal domain with extra C-terminal residues as compared to cleaved 2 form." [PMID:7519994]

organism-modification


PR:000036615
CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble
"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]
Yes
organism-modification


PR:000037469
CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble
"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]
Yes
modification


PR:000002147
CD14 molecule cleaved 2 soluble form
CD14/Clv:2/soluble
"A CD14 molecule cleaved 2 that lacks the GPI-anchor." [PMID:2779588]

organism-modification


PR:000029986
CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]

organism-modification


PR:000035703
CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]
Yes
Yes
organism-modification


PR:000036850
CD14 molecule cleaved and soluble form (mouse)
mCD14/ClvPrd/soluble
"A CD14 molecule cleaved and soluble form in mouse." [PRO:DAN]

Yes
organism-modification


PR:000029986
CD14 molecule cleaved 2 soluble form (mouse)
mCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in mouse." [PRO:DAN]

organism-modification


PR:000037469
CD14 molecule cleaved 1 soluble form (mouse)
mCD14/Clv:1/soluble
"A CD14 molecule cleaved 1 soluble form in mouse. UniProtKB:P10810, 16-358." [PMID:10601848, PMID:18606699, PRO:CNA]

organism-modification


PR:000036945
CD14 molecule cleaved and soluble form (human)
hCD14/ClvPrd/soluble
"A CD14 molecule cleaved and soluble form in human." [PRO:DAN]

organism-modification


PR:000035703
CD14 molecule cleaved 2 soluble form (human)
hCD14/Clv:2/soluble
"A CD14 molecule cleaved 2 soluble form in human." [PRO:DNx, UniProtKB:P08571]

organism-modification


PR:000036615
CD14 molecule cleaved 1 soluble form (human)
hCD14/Clv:1/soluble
"A CD14 molecule cleaved 1 soluble form in human. UniProtKB:P08571, 20-367." [PMID:7519994, PRO:CNA]

organism-modification


PR:000050392
presepsin (human)
hPSEP
"A CD14 molecule, signal peptide removed form that has been cleaved by plasma proteases to yield a soluble 13kD N-terminal fragment in human." [PMID:16258819, PMID:21740312, PMID:25215141, PRO:DAN]

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CD14/SigPep- forms found in complexes   

CD14/SigPep- Component
 Complexes
PR:000002147 CD14/Clv:2/soluble PR:000025494 LPS:secreted CD14 alpha
PR:000025496 lipopolysaccharide receptor complex 2
PR:000025498 lipopolysaccharide receptor complex 4
PR:000002149 CD14/Clv:2/anchored PR:000025493 LPS:GPI-anchored CD14 complex
PR:000025495 lipopolysaccharide receptor complex 1
PR:000025497 lipopolysaccharide receptor complex 3
PR:000035702 hCD14/Clv:2/anchored PR:000025773 lipopolysaccharide receptor complex 3 (human)
PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035703 hCD14/Clv:2/soluble PR:000037463 LPS:secreted CD14 alpha (human)
PR:000037479 lipopolysaccharide receptor complex 4 (human)
PR:000036849 CD14/ClvPrd/soluble PR:000029989 LPS:secreted CD14 complex
PR:000036850 mCD14/ClvPrd/soluble PR:000037467 LPS:secreted CD14 complex (mouse)
PR:000037470 mCD14/Clv:2/anchored PR:000037468 LPS:GPI-anchored CD14 complex (mouse)
PR:000037476 lipopolysaccharide receptor complex 3 (mouse)
PR:000037480 hCD14/Clv:2 PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035702 hCD14/Clv:2/anchored
UniProtKB:P08571, 20-345, Asn-345, MOD:00167		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
located_inGO:0005886 plasma membrane Reactome:REACT_7740
GO:0005886 plasma membrane Reactome:REACT_7740
PR:000035703 hCD14/Clv:2/soluble acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
enablesGO:0001530 lipopolysaccharide binding PMID:9464818
located_inCL:0000129 microglial cell PMID:24659539
GO:0005576 extracellular region PMID:2779588; PMID:9665271
PR:000036615 hCD14/Clv:1/soluble
UniProtKB:P08571, 20-367		 located_inGO:0005576 extracellular region PMID:7519994
PR:000036848 CD14/Clv:2
Example: UniProtKB:P08571, 20-345		 acts_upstream_of_or_withinGO:0032147 activation of protein kinase activity MGI_ref:3836081; PMID:18854309
located_inGO:0005737 cytoplasm MGI_ref:3836081; PMID:18854309
GO:0016020 membrane MGI_ref:3836081; PMID:18854309
PR:000037469 mCD14/Clv:1/soluble
UniProtKB:P10810, 16-358		 located_inCL:0000129 microglial cell PMID:24659539