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Protein Ontology report - cell adhesion molecule CEACAM1, signal peptide removed form
PR:000018399 -
http://purl.obolibrary.org/obo/PR_000018399
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000018399
PRO name
cell adhesion molecule CEACAM1, signal peptide removed form
Synonyms
PRO-Short-label
:
EXACT:
CEACAM1/SigPep-
Definition
"A cell adhesion molecule CEACAM1 that has had the signal peptide removed." [
PMID:8500759
, PRO:KRC]
PRO Category
modification
Parent
PR:000001328
cell adhesion molecule CEACAM1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
15
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000018399
cell adhesion molecule CEACAM1, signal peptide removed form
CEACAM1/SigPep-
"A cell adhesion molecule CEACAM1 that has had the signal peptide removed." [PMID:8500759, PRO:KRC]
union
PR:000044490
CEACAM1a-2 N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2/NGlycoAsp+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of allele CEACAM1a in mouse with two copies of the Ig domain and includes at least one N-glycosylasparagine." [PRO:KRC]
Yes
organism-modification
PR:000044488
CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+
"A CEACAM1a-2S, signal peptide removed form (mouse) that includes at least one N-glycosylasparagine. UniProtKB:P31809-4, 35-278, MOD:00160." [PMID:8380065, PRO:KRC]
organism-modification
PR:000044499
CEACAM1a-2L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2L/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-2L in mouse and includes at least one N-glycosylasparagine. UniProtKB:P31809-3, 35-278, MOD:00160." [PRO:KRC, UniProtKB:P31809]
organism-modification
PR:000044462
CEACAM1a-2S, signal peptide removed form (mouse)
mCEACAM1a/iso:2S/SigPep-
"A CEACAM1a-2S (mouse) that has had the signal peptide removed. UniProtKB:P31809-4, 35-278." [PMID:1648219, PRO:DAN, PRO:KRC, UniProtKB:P31809]
organism-modification
PR:000044488
CEACAM1a-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+
"A CEACAM1a-2S, signal peptide removed form (mouse) that includes at least one N-glycosylasparagine. UniProtKB:P31809-4, 35-278, MOD:00160." [PMID:8380065, PRO:KRC]
Yes
organism-modification
PR:000044463
CEACAM1a-4L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform Long in mouse and includes at least one N-glycosylasparagine. UniProtKB:P31809-1, 35-521, MOD:00160." [PMID:1648219, PMID:8896983, PRO:KRC, UniProtKB:P31809]
Yes
organism-modification
PR:000044464
CEACAM1a-4L, signal peptide removed N-glycosylated and phosphorylated 1 (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoPhos:1
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform Long in mouse, includes at least one N-glycosylasparagine, and has been phosphorylated on Tyr-488 and Tyr-515 residues. UniProtKB:P31809-1, 35-521, Tyr-488/Tyr-515, MOD:00048|MOD:00160." [PMID:1648219, PMID:8896983, PMID:9047385, PMID:9867848, PRO:KRC, UniProtKB:P31809]
Yes
organism-modification
PR:000044465
CEACAM1a-4S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform Short in mouse and includes at least one N-glycosylasparagine. UniProtKB:P31809-2, 35-458, MOD:00160." [PMID:11483763, PMID:1648219, PMID:2164599, PMID:8896983, PRO:KRC, UniProtKB:P31809]
Yes
organism-modification
PR:000044468
CEACAM1b-4S, signal peptide removed form (mouse)
mCEACAM1a/iso:4S/SigPep-
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1b-4S of allele CEACAM1b in mouse. UniProtKB:Q61351, 35-278." [PMID:8500759, PRO:KRC, UniProtKB:P31809]
organism-modification
PR:000044469
CEACAM1a-4C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-4C1 of allele CEACAM1a in mouse and includes at least one N-glycosylasparagine. UniProtKB:Q3LFS5, 35-458, MOD:00160." [PMID:19358828, PRO:KRC]
Yes
organism-modification
PR:000044470
CEACAM1a-2C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-2C1 of allele CEACAM1a in mouse and includes at least one N-glycosylasparagine. UniProtKB:Q3LFS6, 35-270, MOD:00160." [PMID:19358828, PRO:KRC]
Yes
organism-modification
PR:000044471
CEACAM1a-2, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-2 of allele CEACAM1a in mouse and includes at least one N-glycosylasparagine. UniProtKB:Q3LFS7, 35-236, MOD:00160." [PMID:19358828, PRO:KRC]
Yes
organism-modification
PR:000044472
CEACAM1b-2S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1b/iso:2S/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1b-2S of allele CEACAM1b in mouse and includes at least one N-glycosylasparagine. UniProtKB:Q99232, 35-278, MOD:00160." [PMID:1985902, PRO:KRC]
Yes
union
PR:000044489
CEACAM1a-4 N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4/NGlycoAsp+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of allele CEACAM1a in mouse with four copies of the Ig domain and includes at least one N-glycosylasparagine." [PRO:KRC]
Yes
organism-modification
PR:000044463
CEACAM1a-4L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform Long in mouse and includes at least one N-glycosylasparagine. UniProtKB:P31809-1, 35-521, MOD:00160." [PMID:1648219, PMID:8896983, PRO:KRC, UniProtKB:P31809]
organism-modification
PR:000044465
CEACAM1a-4S, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform Short in mouse and includes at least one N-glycosylasparagine. UniProtKB:P31809-2, 35-458, MOD:00160." [PMID:11483763, PMID:1648219, PMID:2164599, PMID:8896983, PRO:KRC, UniProtKB:P31809]
organism-modification
PR:000044499
CEACAM1a-2L, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2L/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-2L in mouse and includes at least one N-glycosylasparagine. UniProtKB:P31809-3, 35-278, MOD:00160." [PRO:KRC, UniProtKB:P31809]
organism-modification
PR:000044501
CEACAM1b-4, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1b/iso:4/SigPep-/NGlycoAsn+
"A CEACAM1b-4 (mouse) that has had the signal peptide removed and that includes at least one N-glycosylasparagine." [PMID:1648219, PRO:KRC, UniProtKB:P31809]
Yes
organism-modification
PR:000044502
CEACAM1a-C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:C1/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form in mouse that lacks the transmembrane domain, and includes at least one N-glycosylasparagine." [PRO:KRC]
Yes
organism-modification
PR:000044469
CEACAM1a-4C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-4C1 of allele CEACAM1a in mouse and includes at least one N-glycosylasparagine. UniProtKB:Q3LFS5, 35-458, MOD:00160." [PMID:19358828, PRO:KRC]
organism-modification
PR:000044470
CEACAM1a-2C1, signal peptide removed N-glycosylasparagine form (mouse)
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-2C1 of allele CEACAM1a in mouse and includes at least one N-glycosylasparagine. UniProtKB:Q3LFS6, 35-270, MOD:00160." [PMID:19358828, PRO:KRC]
organism-modification
PR:000044512
CEACAM1a-2L, signal peptide removed and phosphorylated 1 (mouse)
mCEACAM1a/iso:2L/SigPep-/Phos:1
"A cell adhesion molecule CEACAM1, signal peptide removed form that is the signal cleavage product of isoform CEACAM1a-2L and has been phosphorylated in Tyr residues within the two ITIM motifs in mouse. UniProtKB:P31809-3, 35-278, Tyr-308/Tyr-335, MOD:00048." [PMID:17081782, PRO:KRC, UniProtKB:P31809]
organism-modification
PR:000046685
cell adhesion molecule CEACAM1, signal peptide removed form (human)
hCEACAM1/SigPep-
"A cell adhesion molecule CEACAM1 (human) that has had the signal peptide removed. UniProtKB:P13688, 35-526." [PRO:DNx, Reactome:R-HSA-197701]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000044463
mCEACAM1a/iso:4L/SigPep-/NGlycoAsn+
UniProtKB:P31809-1, 35-521, MOD:00160
acts_upstream_of_or_within
GO:0032703
negative regulation of interleukin-2 production
MGI_ref:3693042;
PMID:17081782
GO:0042130
negative regulation of T cell proliferation
MGI_ref:5451119;
PMID:23123061
GO:0042130
negative regulation of T cell proliferation
MGI_ref:5451119;
PMID:23123061
located_in
GO:0009897
external side of plasma membrane
MGI_ref:3693042;
PMID:17081782
PR:000044464
mCEACAM1a/iso:4L/SigPep-/NGlycoPhos:1
UniProtKB:P31809-1, 35-521, Tyr-488/Tyr-515, MOD:00048|MOD:00160
enables
GO:0005515
protein binding
with
PR:P29351
70Z-SHP (mouse)
MGI_ref:1326994;
PMID:9867848
GO:0005515
protein binding
with
PR:P29351
70Z-SHP (mouse)
MGI_ref:1326994;
PMID:9867848
GO:0005515
protein binding
with
PR:P35235
mPTPN11
MGI_ref:1326994;
PMID:9867848
PR:000044465
mCEACAM1a/iso:4S/SigPep-/NGlycoAsn+
UniProtKB:P31809-2, 35-458, MOD:00160
acts_upstream_of_or_within
GO:0002639
positive regulation of immunoglobulin production
MGI_ref:5451119;
PMID:23123061
GO:0016338
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
MGI_ref:5608586;
PMID:1633107
GO:0042102
positive regulation of T cell proliferation
MGI_ref:5451119;
PMID:23123061
GO:0046718
symbiont entry into host cell
MGI_ref:49235;
PMID:1719235
GO:0048541
Peyer's patch development
MGI_ref:5451119;
PMID:23123061
GO:0070237
positive regulation of activation-induced cell death of T cells
MGI_ref:5451119;
PMID:23123061
GO:0070886
positive regulation of calcineurin-NFAT signaling cascade
MGI_ref:5451119;
PMID:23123061
GO:2000516
positive regulation of CD4-positive, alpha-beta T cell activation
MGI_ref:5451119;
PMID:23123061
GO:2000563
positive regulation of CD4-positive, alpha-beta T cell proliferation
MGI_ref:5451119;
PMID:23123061
GO:2001187
positive regulation of CD8-positive, alpha-beta T cell activation
MGI_ref:5451119;
PMID:23123061
enables
GO:0001618
virus receptor activity
MGI_ref:49235;
PMID:1719235
GO:0046790
virion binding
MGI_ref:3053174;
PMID:8380065
located_in
GO:0009897
external side of plasma membrane
MGI_ref:81180;
PMID:8896983
GO:0009897
external side of plasma membrane
MGI_ref:81180;
PMID:8896983
PR:000044469
mCEACAM1a/iso:4C1/SigPep-/NGlycoAsn+
UniProtKB:Q3LFS5, 35-458, MOD:00160
acts_upstream_of_or_within
GO:0044793
host-mediated suppression of viral proces
MGI_ref:3848729;
PMID:19358828
located_in
GO:0005615
extracellular space
MGI_ref:3848729;
PMID:19358828
PR:000044470
mCEACAM1a/iso:2C1/SigPep-/NGlycoAsn+
UniProtKB:Q3LFS6, 35-270, MOD:00160
located_in
GO:0005615
extracellular space
MGI_ref:3848729;
PMID:19358828
PR:000044471
mCEACAM1a/iso:2/SigPep-/NGlycoAsn+
UniProtKB:Q3LFS7, 35-236, MOD:00160
located_in
GO:0005615
extracellular space
MGI_ref:3848729;
PMID:19358828
PR:000044472
mCEACAM1b/iso:2S/SigPep-/NGlycoAsn+
UniProtKB:Q99232, 35-278, MOD:00160
enables
NOT
GO:0046790
virion binding
MGI_ref:3053174;
PMID:8380065
PR:000044488
mCEACAM1a/iso:2S/SigPep-/NGlycoAsn+
UniProtKB:P31809-4, 35-278, MOD:00160
enables
GO:0046790
virion binding
MGI_ref:3053174;
PMID:8380065
PR:000044489
mCEACAM1a/iso:4/NGlycoAsp+
acts_upstream_of_or_within
GO:0044794
host-mediated activation of viral process
MGI_ref:2148352;
PMID:11483763
enables
NOT
GO:0001618
virus receptor activity
MGI_ref:5608587;
PMID:2164599
located_in
GO:0016020
membrane
MGI_ref:73162;
PMID:1648219
GO:0016020
membrane
MGI_ref:73162;
PMID:1648219
GO:0016020
membrane
MGI_ref:73162;
PMID:1648219
GO:0031526
brush border membrane
MGI_ref:73162;
PMID:1648219
PR:000044490
mCEACAM1a/iso:2/NGlycoAsp+
acts_upstream_of_or_within
GO:0044793
host-mediated suppression of viral proces
MGI_ref:2148352;
PMID:11483763
enables
NOT
GO:0001618
virus receptor activity
MGI_ref:5608587;
PMID:2164599
located_in
GO:0016020
membrane
MGI_ref:63233;
PMID:8402684
GO:0016020
membrane
MGI_ref:63233;
PMID:8402684
GO:0031526
brush border membrane
MGI_ref:73162;
PMID:1648219
PR:000044501
mCEACAM1b/iso:4/SigPep-/NGlycoAsn+
located_in
GO:0031526
brush border membrane
MGI_ref:73162;
PMID:1648219
PR:000044502
mCEACAM1a/iso:C1/SigPep-/NGlycoAsn+
located_in
GO:0005615
extracellular space
MGI_ref:3848729;
PMID:19358828
