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Protein Ontology report - TGF-beta 2 proteolytic cleavage product
PR:000018293 - http://purl.obolibrary.org/obo/PR_000018293
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000018293   
  PRO nameTGF-beta 2 proteolytic cleavage product 
  Synonyms
PRO-Short-label: EXACT:TGFB2/ClvPrd
  Definition"A TGF-beta 2 that has been processed by proteolytic cleavage." [PRO:DNx] 
  PRO Categorymodification 
  ParentPR:000000183 TGF-beta 2
PR:000018264 proteolytic cleavage product
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification6                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
modification



PR:000018293

TGF-beta 2 proteolytic cleavage product

TGFB2/ClvPrd


"A TGF-beta 2 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000629

TGF-beta 2 isoform A cleaved 1

TGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A that has been processed by proteolytic cleavage and released from the latent complex. This form, cross-linked to an identical chain, is the active mature protein." [PMID:3476488]


organism-modification



PR:000036530

TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]

Yes

modification



PR:000000630

TGF-beta 2 isoform A cleaved 2

TGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent removal of the C-terminal mature protein. This chain is referred as to the latency associated peptide (LAP)." [PRO:CNA]


organism-modification



PR:000036531

TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in mouse. UniProtKB:P27090-1, 20-302." [PMID:14985127, PRO:CNA]

Yes

organism-modification



PR:000036532

TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]

Yes

modification



PR:000000631

TGF-beta 2 isoform A cleaved 3

TGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:10224129]


organism-modification



PR:000036533

TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]

Yes

modification



PR:000000632

TGF-beta 2 isoform B cleaved 1

TGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature peptide." [PMID:1777240]


organism-modification



PR:000036534

TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]

Yes

modification



PR:000000633

TGF-beta 2 isoform B cleaved 2

TGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:1777240]


organism-modification



PR:000036535

TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000036530 hTGFB2/iso:A/Clv:1 PMID:3162913
GO:0008285 negative regulation of cell population proliferationPR:000036530 hTGFB2/iso:A/Clv:1 PMID:15944186

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0001540 amyloid-beta bindingPR:000036530 hTGFB2/iso:A/Clv:1 PMID:16227582
GO:0005160 transforming growth factor beta receptor bindingPR:000036530 hTGFB2/iso:A/Clv:1 PMID:16227582
GO:0005515 protein bindingPR:000036531 mTGFB2/iso:A/Clv:2 PMID:14985127
GO:0042803 protein homodimerization activityPR:000036530 hTGFB2/iso:A/Clv:1 PMID:2119582; PMID:3476488
PR:000036533 hTGFB2/iso:A/Clv:3 PMID:3476488

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000036530 hTGFB2/iso:A/Clv:1 PMID:3162913
PR:000036533 hTGFB2/iso:A/Clv:3 PMID:3162913
PR:000036534 hTGFB2/iso:B/Clv:1 PMID:1777240
PR:000036535 hTGFB2/iso:B/Clv:2 PMID:1777240
GO:0032991 protein-containing complexPR:000036532 hTGFB2/iso:A/Clv:2 PMID:3162913