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Protein Ontology report - tumor necrosis factor proteolytic cleavage product
PR:000018285 - http://purl.obolibrary.org/obo/PR_000018285
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000018285   
  PRO nametumor necrosis factor proteolytic cleavage product 
  Synonyms
PRO-Short-label: EXACT:TNF/ClvPrd
  Definition"A tumor necrosis factor that has been processed by proteolytic cleavage." [PRO:DNx] 
  PRO Categorymodification 
  ParentPR:000000134 tumor necrosis factor
PR:000018264 proteolytic cleavage product
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
modification



PR:000018285

tumor necrosis factor proteolytic cleavage product

TNF/ClvPrd


"A tumor necrosis factor that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000604

tumor necrosis factor isoform 1 cleaved 1

TNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [PMID:12135369]


organism-modification



PR:000036504

tumor necrosis factor isoform 1 cleaved 1 (human)

hTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]

Yes

organism-modification



PR:000036505

tumor necrosis factor isoform 1 cleaved 1 (mouse)

mTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]

Yes

modification



PR:000000605

tumor necrosis factor isoform 1 cleaved 2

TNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 that is the inactive soluble form after alternative protein processing. The resulting protein is 10 amino acids longer than the active form." [PMID:2777790, PRO:CNA, PRO:DAN]


organism-modification



PR:000036506

tumor necrosis factor isoform 1 cleaved 2 (mouse)

mTNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000036505 mTNF/iso:1/Clv:1 PMID:9305915
GO:0006915 apoptotic processPR:000036504 hTNF/iso:1/Clv:1 PMID:3856324

Molecular Function GO Term

Protein Forms & Complexes

Evidence
NOT GO:0005125 cytokine activityPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005164 tumor necrosis factor receptor bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
GO:0042802 identical protein bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005576 extracellular regionPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005615 extracellular spacePR:000036505 mTNF/iso:1/Clv:1 PMID:10089307