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Protein Ontology report - transcriptional coactivator YAP1
PR:000017522 - http://purl.obolibrary.org/obo/PR_000017522
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000017522   
  PRO nametranscriptional coactivator YAP1 
  Synonyms
PRO-Short-label: EXACT:YAP1
Gene-based: RELATED:Yap | YAP65
Other: EXACT:65 kDa Yes-associated protein | protein yorkie homolog | Yes-associated protein 1 | Yes-associated protein YAP65 homolog | yorkie homolog
  Definition"A protein that is a translation product of the human YAP1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence0                                                  Organism-Sequence 15                                        
         Modification0                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000017522

transcriptional coactivator YAP1

YAP1


"A protein that is a translation product of the human YAP1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P46936

transcriptional coactivator YAP1 (chicken)

chick-YAP1


"A transcriptional coactivator YAP1 that is encoded in the genome of chicken." [PRO:DNx]


organism-gene



PR:P46937

transcriptional coactivator YAP1 (human)

hYAP1


"A transcriptional coactivator YAP1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-1

transcriptional coactivator YAP1 isoform h1 (human)

hYAP1/iso:h1


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-1." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-2

transcriptional coactivator YAP1 isoform h2 (human)

hYAP1/iso:h2


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-2." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-3

transcriptional coactivator YAP1 isoform 3 (human)

hYAP1/iso:3


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-3." [PRO:DNx, UniProtKB:P46937]


organism-modification



PR:000037507

transcriptional coactivator YAP1 isoform 3 unphosphorylated 1 (human)

hYAP1/iso:3/UnPhos:1


"A transcriptional coactivator YAP1 isoform 3 (human) that lacks a phosphorylated Tyr residue at position 357. UniProtKB:P46937-3, Tyr-357, PR:000026291." [PMID:21214929, PMID:21945154, PRO:KER]

Yes

organism-modification



PR:000037508

transcriptional coactivator YAP1 isoform 3 phosphorylated 1 (human)

hYAP1/iso:3/Phos:1


"A transcriptional coactivator YAP1 isoform 3 (human) that has been phosphorylated on a Tyr residue at position 357. UniProtKB:P46937-3, Tyr-357, MOD:00048." [PMID:21214929, PMID:21945154, PRO:KER]

Yes

organism-sequence



PR:P46937-4

transcriptional coactivator YAP1 isoform h4 (human)

hYAP1/iso:h4


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-4." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-5

transcriptional coactivator YAP1 isoform h5 (human)

hYAP1/iso:h5


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-5." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-6

transcriptional coactivator YAP1 isoform h6 (human)

hYAP1/iso:h6


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-6." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-7

transcriptional coactivator YAP1 isoform h7 (human)

hYAP1/iso:h7


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-7." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-8

transcriptional coactivator YAP1 isoform h8 (human)

hYAP1/iso:h8


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-8." [PRO:DNx, UniProtKB:P46937]


organism-sequence



PR:P46937-9

transcriptional coactivator YAP1 isoform h9 (human)

hYAP1/iso:h9


"A transcriptional coactivator YAP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46937-9." [PRO:DNx, UniProtKB:P46937]


organism-modification



PR:000037509

transcriptional coactivator YAP1 unphosphorylated 1 (human)

hYAP1/UnPhos:1


"A transcriptional coactivator YAP1 (human) that lacks phosphorylation on the residue at the position equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-127, PR:000026291." [PMID:21214929, PMID:21945154, PRO:KER]


organism-modification



PR:000037510

transcriptional coactivator YAP1 phosphorylated 1 (human)

hYAP1/Phos:1


"A transcriptional coactivator YAP1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-127 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-127, MOD:00046." [PMID:20153295, PMID:21214929, PMID:21945154, PRO:KER]

Yes

organism-modification



PR:000045791

transcriptional coactivator YAP1 phosphorylated 2 (human)

hYAP1/Phos:2


"A transcriptional coactivator YAP1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-94 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Ser-94, MOD:00046." [iPTMnet:P46937, PMID:25751140]


organism-modification



PR:000049715

transcriptional coactivator YAP1 phosphorylated 3 (human)

hYAP1/Phos:3


"A transcriptional coactivator YAP1 (human) that has been post-translationally modified to include phosphoserine at positions 61, 109, 127, 164 and 397 of the amino acid sequence represented by UniProtKB:P46937. UniProtKB:P46937, Ser-61/Ser-109/Ser-127/Ser-164/Ser-397, MOD:00046." [PRO:DNx, Reactome:R-HSA-2028554]


organism-modification



PR:000063813

transcriptional coactivator YAP1 phosphotyrosine form (human)

hYAP1/PhosTyr+


"A transcriptional coactivator YAP1 (human) that includes at least one phosphorylated tyrosine. UniProtKB:P46937, MOD:00048." [PRO:DNx, Reactome:R-HSA-8937843, Reactome:R-HSA-8937857]


organism-modification



PR:000064465

transcriptional coactivator YAP1 phosphorylated 4 (human)

hYAP1/Phos:4


"A transcriptional coactivator YAP1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-407 of the amino acid sequence represented by UniProtKB:P46937-1. Example: UniProtKB:P46937-1, Tyr-407, MOD:00048." [PRO:DNx, Reactome:R-HSA-8956661]


organism-gene



PR:P46938

transcriptional coactivator YAP1 (mouse)

mYAP1


"A transcriptional coactivator YAP1 that is encoded in the genome of mouse." [OMA:P46938, PRO:DNx]


organism-sequence



PR:P46938-1

transcriptional coactivator YAP1 isoform m1 (mouse)

mYAP1/iso:m1


"A transcriptional coactivator YAP1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46938-1." [PRO:DNx, UniProtKB:P46938]


organism-sequence



PR:P46938-2

transcriptional coactivator YAP1 isoform m2 (mouse)

mYAP1/iso:m2


"A transcriptional coactivator YAP1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46938-2." [PRO:DNx, UniProtKB:P46938]


organism-gene



PR:Q1L8J7

transcriptional coactivator YAP1 (zebrafish)

z-YAP1


"A transcriptional coactivator YAP1 that is encoded in the genome of zebrafish." [OMA:Q1L8J7, PRO:DNx]


organism-gene



PR:Q2EJA0

transcriptional coactivator YAP1 (rat)

rYAP1


"A transcriptional coactivator YAP1 that is encoded in the genome of rat." [OMA:Q2EJA0, PRO:DNx]


organism-sequence



PR:Q2EJA0-1

transcriptional coactivator YAP1 isoform r1 (rat)

rYAP1/iso:r1


"A transcriptional coactivator YAP1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q2EJA0-1." [PRO:DNx, UniProtKB:Q2EJA0]


organism-sequence



PR:Q2EJA0-2

transcriptional coactivator YAP1 isoform r2 (rat)

rYAP1/iso:r2


"A transcriptional coactivator YAP1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q2EJA0-2." [PRO:DNx, UniProtKB:Q2EJA0]


organism-sequence



PR:Q2EJA0-3

transcriptional coactivator YAP1 isoform r3 (rat)

rYAP1/iso:r3


"A transcriptional coactivator YAP1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q2EJA0-3." [PRO:DNx, UniProtKB:Q2EJA0]


organism-sequence



PR:Q2EJA0-4

transcriptional coactivator YAP1 isoform r4 (rat)

rYAP1/iso:r4


"A transcriptional coactivator YAP1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q2EJA0-4." [PRO:DNx, UniProtKB:Q2EJA0]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037507 hYAP1/iso:3/UnPhos:1
UniProtKB:P46937-3, Tyr-357, PR:000026291
enablesGO:0005515 protein binding with PR:O15350 hTP73 PMID:21214929; PMID:21562856
PR:000037508 hYAP1/iso:3/Phos:1
UniProtKB:P46937-3, Tyr-357, MOD:00048
associated_with_disease_progressionDO:10652 Alzheimer's disease PMID:21562856
enablesincreased GO:0005515 protein binding with PR:O15350 hTP73 PMID:21214929; PMID:21562856
located_inD162 cancer PMID:21214929
GO:0005634 nucleus PMID:21562856
PR:000037510 hYAP1/Phos:1
Example: UniProtKB:P46937-1, Ser-127, MOD:00046
associated_with_disease_progressionDO:162 cancer PMID:21214929
enablesdecreased GO:0005515 protein binding with PR:000003237 fam:14-3-3 PMID:21945154
decreased GO:0005515 protein binding with PR:O15350 hTP73 PMID:21945154
located_inD10652 Alzheimer's disease PMID:21945154