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Protein Ontology report - vascular endothelial growth factor A, long form
PR:000017284 - http://purl.obolibrary.org/obo/PR_000017284
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000017284   
  PRO namevascular endothelial growth factor A, long form 
  Synonyms
PRO-Short-label: EXACT:VEGFA
Gene-based: RELATED:VEGF
Other: EXACT:L-VEGF | vascular endothelial growth factor A | vascular permeability factor | VEGF-A | VPF
  Definition"A protein that is a translation product of the human VEGFA gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence3                                                  Organism-Sequence 30                                        
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000017284
vascular endothelial growth factor A, long form
VEGFA
"A protein that is a translation product of the human VEGFA gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:O73682
vascular endothelial growth factor A-A (zebrafish)
z-VEGFA
"A vascular endothelial growth factor A, long form that is encoded in the genome of zebrafish." [OMA:O73682, PRO:DNx]

organism-sequence


PR:O73682-1
vascular endothelial growth factor A-A isoform VEGF165 (zebrafish)
z-VEGFA/iso:VEGF165
"A vascular endothelial growth factor A-A (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O73682-1." [PRO:DNx, UniProtKB:O73682]

organism-sequence


PR:O73682-2
vascular endothelial growth factor A-A isoform VEGF121 (zebrafish)
z-VEGFA/iso:VEGF121
"A vascular endothelial growth factor A-A (zebrafish) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O73682-2." [PRO:DNx, UniProtKB:O73682]

organism-gene


PR:P15692
vascular endothelial growth factor A, long form (human)
hVEGFA
"A vascular endothelial growth factor A, long form that is encoded in the genome of human." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-1
vascular endothelial growth factor A, long form isoform VEGF206 (human)
hVEGFA/iso:VEGF206
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-1." [PRO:DNx, UniProtKB:P15692]

organism-modification


PR:000049655
vascular endothelial growth factor A isoform VEGF206, signal peptide removed form (human)
hVEGFA/iso:VEGF206/SigPep-
"A vascular endothelial growth factor A, long form isoform VEGF206 (human) that has had the signal peptide removed. UniProtKB:P15692-1, 27-232." [PRO:DNx]

organism-sequence


PR:P15692-10
vascular endothelial growth factor A, long form isoform hVEGF111 (human)
hVEGFA/iso:hVEGF111
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-10." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-11
vascular endothelial growth factor A, long form isoform hL-VEGF165 (human)
hVEGFA/iso:hL-VEGF165
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-11." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-12
vascular endothelial growth factor A, long form isoform hL-VEGF121 (human)
hVEGFA/iso:hL-VEGF121
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-12." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-13
vascular endothelial growth factor A, long form isoform hL-VEGF189 (human)
hVEGFA/iso:hL-VEGF189
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-13." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-14
vascular endothelial growth factor A, long form isoform hL-VEGF206 (human)
hVEGFA/iso:hL-VEGF206
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-14." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-15
vascular endothelial growth factor A, long form isoform h15 (human)
hVEGFA/iso:h15
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-15." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-16
vascular endothelial growth factor A, long form isoform h16 (human)
hVEGFA/iso:h16
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-16." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-17
vascular endothelial growth factor A, long form isoform h17 (human)
hVEGFA/iso:h17
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-17." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-18
vascular endothelial growth factor A, long form isoform h18 (human)
hVEGFA/iso:h18
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-18." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-2
vascular endothelial growth factor A, long form isoform hVEGF189 (human)
hVEGFA/iso:hVEGF189
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-2." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-3
vascular endothelial growth factor A, long form isoform hVEGF183 (human)
hVEGFA/iso:hVEGF183
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-3." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-4
vascular endothelial growth factor A, long form isoform VEGF165 (human)
hVEGFA/iso:VEGF165
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-4." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-5
vascular endothelial growth factor A, long form isoform hVEGF148 (human)
hVEGFA/iso:hVEGF148
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-5." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-6
vascular endothelial growth factor A, long form isoform hVEGF145 (human)
hVEGFA/iso:hVEGF145
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-6." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-8
vascular endothelial growth factor A, long form isoform hVEGF165B (human)
hVEGFA/iso:hVEGF165B
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-8." [PRO:DNx, UniProtKB:P15692]

organism-sequence


PR:P15692-9
vascular endothelial growth factor A, long form isoform hVEGF121 (human)
hVEGFA/iso:hVEGF121
"A vascular endothelial growth factor A, long form (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P15692-9." [PRO:DNx, UniProtKB:P15692]

organism-gene


PR:P16612
vascular endothelial growth factor A (rat)
rVEGFA
"A vascular endothelial growth factor A, long form that is encoded in the genome of rat." [OMA:P16612, PRO:DNx]

organism-sequence


PR:P16612-1
vascular endothelial growth factor A isoform 1 (rat)
rVEGFA/iso:1
"A vascular endothelial growth factor A, long form isoform 1 that is encoded in the genome of rat." [PMID:11163598, PRO:CNA]

organism-sequence


PR:P16612-2
vascular endothelial growth factor A isoform 2 (rat)
rVEGFA/iso:2
"A vascular endothelial growth factor A, long form isoform 2 that is encoded in the genome of rat." [PMID:11163598, PRO:CNA]

organism-sequence


PR:P16612-3
vascular endothelial growth factor A isoform rVEGF-A144 (rat)
rVEGFA/iso:rVEGF-A144
"A vascular endothelial growth factor A (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16612-3." [PRO:DNx, UniProtKB:P16612]

organism-sequence


PR:P16612-4
vascular endothelial growth factor A isoform 3 (rat)
rVEGFA/iso:3
"A vascular endothelial growth factor A, long form isoform 3 that is encoded in the genome of rat." [PMID:11163598, PRO:CNA]

organism-gene


PR:P67964
vascular endothelial growth factor A (chicken)
chick-VEGFA
"A vascular endothelial growth factor A, long form that is encoded in the genome of chicken." [OMA:P67964, PRO:DNx]

organism-gene


PR:Q00731
vascular endothelial growth factor A, long form (mouse)
mVEGFA
"A vascular endothelial growth factor A, long form that is encoded in the genome of mouse." [OMA:Q00731, PRO:DNx]

organism-sequence


PR:Q00731-1
vascular endothelial growth factor A, long form isoform 1 (mouse)
mVEGFA/iso:1
"A vascular endothelial growth factor A, long form isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-sequence


PR:Q00731-2
vascular endothelial growth factor A, long form isoform 2 (mouse)
mVEGFA/iso:2
"A vascular endothelial growth factor A, long form isoform 2 that is encoded in the genome of mouse." [PMID:8614412, PRO:KRC]
Yes
organism-sequence


PR:Q00731-3
vascular endothelial growth factor A, long form isoform 3 (mouse)
mVEGFA/iso:3
"A vascular endothelial growth factor A, long form isoform 3 that is encoded in the genome of mouse." [PMID:8614412, PRO:KRC]
Yes
organism-sequence


PR:Q00731-4
vascular endothelial growth factor A, long form isoform 4 (mouse)
mVEGFA/iso:4
"A vascular endothelial growth factor A, long form (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-4." [PMID:9446618, PRO:KRC]
Yes
organism-sequence


PR:Q00731-5
vascular endothelial growth factor A, long form isoform mVEGF-5 (mouse)
mVEGFA/iso:mVEGF-5
"A vascular endothelial growth factor A, long form (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-5." [PRO:DNx, UniProtKB:Q00731]

organism-sequence


PR:Q00731-6
vascular endothelial growth factor A, long form isoform 6 (mouse)
mVEGFA/iso:6
"A vascular endothelial growth factor A, long form (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-6." [PMID:11731620, PRO:KRC]

organism-sequence


PR:Q00731-7
vascular endothelial growth factor A, long form isoform mL-VEGF-2 (mouse)
mVEGFA/iso:mL-VEGF-2
"A vascular endothelial growth factor A, long form (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-7." [PRO:DNx, UniProtKB:Q00731]

sequence


PR:000037369
vascular endothelial growth factor A, long form isoform 1
VEGFA/iso:1
"A vascular endothelial growth factor A, long form that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-1 or a 1:1 ortholog thereof." [PMID:8614412, PRO:KRC]

organism-sequence


PR:P16612-1
vascular endothelial growth factor A isoform 1 (rat)
rVEGFA/iso:1
"A vascular endothelial growth factor A, long form isoform 1 that is encoded in the genome of rat." [PMID:11163598, PRO:CNA]

organism-sequence


PR:Q00731-1
vascular endothelial growth factor A, long form isoform 1 (mouse)
mVEGFA/iso:1
"A vascular endothelial growth factor A, long form isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

sequence


PR:000037370
vascular endothelial growth factor A, long form isoform 2
VEGFA/iso:2
"A vascular endothelial growth factor A, long form that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-2 or a 1:1 ortholog thereof." [PMID:8614412, PRO:KRC]

organism-sequence


PR:P16612-2
vascular endothelial growth factor A isoform 2 (rat)
rVEGFA/iso:2
"A vascular endothelial growth factor A, long form isoform 2 that is encoded in the genome of rat." [PMID:11163598, PRO:CNA]

organism-sequence


PR:Q00731-2
vascular endothelial growth factor A, long form isoform 2 (mouse)
mVEGFA/iso:2
"A vascular endothelial growth factor A, long form isoform 2 that is encoded in the genome of mouse." [PMID:8614412, PRO:KRC]
Yes
sequence


PR:000037371
vascular endothelial growth factor A, long form isoform 3
VEGFA/iso:3
"A vascular endothelial growth factor A, long form that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00731-3 or a 1:1 ortholog thereof." [PMID:8614412, PRO:KRC]

organism-sequence


PR:P16612-4
vascular endothelial growth factor A isoform 3 (rat)
rVEGFA/iso:3
"A vascular endothelial growth factor A, long form isoform 3 that is encoded in the genome of rat." [PMID:11163598, PRO:CNA]

organism-sequence


PR:Q00731-3
vascular endothelial growth factor A, long form isoform 3 (mouse)
mVEGFA/iso:3
"A vascular endothelial growth factor A, long form isoform 3 that is encoded in the genome of mouse." [PMID:8614412, PRO:KRC]
Yes
modification


PR:000021820
vascular endothelial growth factor A, long form, signal peptide removed form
VEGFA/SigPep-
"A vascular endothelial growth factor A, long form that has had the signal peptide removed." [PRO:DNx]

organism-modification


PR:000049655
vascular endothelial growth factor A isoform VEGF206, signal peptide removed form (human)
hVEGFA/iso:VEGF206/SigPep-
"A vascular endothelial growth factor A, long form isoform VEGF206 (human) that has had the signal peptide removed. UniProtKB:P15692-1, 27-232." [PRO:DNx]

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q00731-2 mVEGFA/iso:2 acts_upstream_of_or_withinGO:0001525 angiogenesis MGI_ref:3758404; PMID:17626017
GO:0001569 branching involved in blood vessel morphogenesis MGI_ref:3710026; PMID:17428830
GO:0001938 positive regulation of endothelial cell proliferation MGI_ref:74931; PMID:1592003
GO:0002053 positive regulation of mesenchymal cell proliferation MGI_ref:3613102; PMID:16375885
GO:0030324 lung development MGI_ref:3613102; PMID:16375885
GO:0048010 vascular endothelial growth factor receptor signaling pathway MGI_ref:74931; PMID:1592003
GO:0048754 branching morphogenesis of an epithelial tube MGI_ref:3613102; PMID:16375885
GO:0060426 lung vasculature development MGI_ref:1927039; PMID:11066091
enablesGO:0005102 signaling receptor binding MGI_ref:3758404; PMID:17626017
GO:0005515 protein binding MGI_ref:1860784; PMID:10705382
GO:0008201 heparin binding MGI_ref:77585; PMID:8614412
GO:0008201 heparin binding MGI_ref:77585; PMID:8614412
GO:0043183 vascular endothelial growth factor receptor 1 binding MGI_ref:3758404; PMID:17626017
GO:0043184 vascular endothelial growth factor receptor 2 binding MGI_ref:1860784; PMID:10705382
GO:0043184 vascular endothelial growth factor receptor 2 binding MGI_ref:1860784; PMID:10705382
GO:0050840 extracellular matrix binding MGI_ref:3758404; PMID:17626017
located_inGO:0005576 extracellular region MGI_ref:77585; PMID:8614412
PR:Q00731-3 mVEGFA/iso:3 acts_upstream_of_or_withinGO:0001525 angiogenesis MGI_ref:3758404; PMID:17626017
GO:0001938 positive regulation of endothelial cell proliferation MGI_ref:74931; PMID:1592003
GO:0048010 vascular endothelial growth factor receptor signaling pathway MGI_ref:74931; PMID:1592003
located_inGO:0005576 extracellular region MGI_ref:77585; PMID:8614412
GO:0005615 extracellular space MGI_ref:74931; PMID:1592003
PR:Q00731-4 mVEGFA/iso:4 acts_upstream_of_or_withinGO:0001938 positive regulation of endothelial cell proliferation MGI_ref:1195544; PMID:9446618
enablesGO:0008083 growth factor activity MGI_ref:1195544; PMID:9446618
located_inGO:0005576 extracellular region MGI_ref:1195544; PMID:9446618