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Protein Ontology report - dual specificity protein kinase TTK
PR:000016787 - http://purl.obolibrary.org/obo/PR_000016787
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000016787   
  PRO namedual specificity protein kinase TTK 
  Synonyms
PRO-Short-label: EXACT:TTK
Gene-based: RELATED:MPS1 | MPS1L1
Other: EXACT:ESK | Monopolar spindle protein 1 | phosphotyrosine picked threonine-protein kinase | PYT | Regulatory cell proliferation kinase 1
RELATED:RPK1 | serine/threonine-protein kinase MPS1
  Definition"A protein that is a translation product of the human TTK gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2264
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000016787

dual specificity protein kinase TTK

TTK


"A protein that is a translation product of the human TTK gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P33981

dual specificity protein kinase TTK (human)

hTTK


"A dual specificity protein kinase TTK that is encoded in the genome of human." [PMID:20823832, PRO:KER]

Yes

organism-sequence



PR:P33981-1

dual specificity protein kinase TTK isoform h1 (human)

hTTK/iso:h1


"A dual specificity protein kinase TTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33981-1." [PRO:DNx, UniProtKB:P33981]


organism-sequence



PR:P33981-2

dual specificity protein kinase TTK isoform h2 (human)

hTTK/iso:h2


"A dual specificity protein kinase TTK (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P33981-2." [PRO:DNx, UniProtKB:P33981]


organism-modification



PR:000045754

dual specificity protein kinase TTK phosphorylated 1 (human)

hTTK/Phos:1


"A dual specificity protein kinase TTK (human) that has been phosphorylated on the residue at the position equivalent to Thr-676 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, Thr-676, MOD:00047." [iPTMnet:P33981, PMID:18083840, PMID:18680479, PMID:19120698, PRO:KER]

Yes

organism-modification



PR:000049844

TTK activation loop phosphorylated form (human)

hTTK/(Act-loop)Phos+


"A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop, at positions equivalent to Thr-675 or Thr-676 or Ser-677 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)." [PMID:17728254, PMID:18923149, PMID:19120698, PRO:KER]

Yes

organism-modification



PR:000049845

TTK activation loop and P+1 loop phosphorylated form (human)

hTTK/(Act-loop_P+1-loop)Phos+


"A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop and on a Thr residue in the P+1 loop. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047." [PMID:19120698, PRO:KER]

Yes

organism-modification



PR:000083646

dual specificity protein kinase TTK methylated 1 (human)

hTTK/Me:1


"A dual specificity protein kinase TTK (human) that has been methylated on the residue at the position equivalent to Cys-517 of the amino acid sequence represented by UniProtKB:P33981-1. Example: UniProtKB:P33981-1, Cys-517, MOD:00660." [IEDB_epitope:1047616, PRO:DNx]


organism-gene



PR:P35761

dual specificity protein kinase TTK (mouse)

mTTK


"A dual specificity protein kinase TTK that is encoded in the genome of mouse." [OMA:MOUSE23899, PRO:DNx]


organism-sequence



PR:P35761-1

dual specificity protein kinase TTK isoform m1 (mouse)

mTTK/iso:m1


"A dual specificity protein kinase TTK (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35761-1." [PRO:DNx, UniProtKB:P35761]


organism-sequence



PR:P35761-2

dual specificity protein kinase TTK isoform m2 (mouse)

mTTK/iso:m2


"A dual specificity protein kinase TTK (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35761-2." [PRO:DNx, UniProtKB:P35761]


organism-modification



PR:000049885

dual specificity protein kinase TTK isoform m2 phosphorylated 1 (mouse)

mTTK/iso:m2/Phos:1


"A dual specificity protein kinase TTK isoform m2 (mouse) that has been phosphorylated on the residue at the position equivalent to Thr-402 of the amino acid sequence represented by UniProtKB:P35761-2. UniProtKB:P35761-2, Thr-402, MOD:00047." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049886

dual specificity protein kinase TTK isoform m2 phosphorylated 2 (mouse)

mTTK/iso:m2/Phos:2


"A dual specificity protein kinase TTK isoform m2 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-794 of the amino acid sequence represented by UniProtKB:P35761-2. UniProtKB:P35761-2, Ser-794, MOD:00046." [PMID:21183079, PRO:HJD]


organism-modification



PR:000049884

dual specificity protein kinase TTK phosphorylated 1 (mouse)

mTTK/Phos:1


"A dual specificity protein kinase TTK (mouse) that has been phosphorylated on residues at positions equivalent to Thr-284 and Ser-287 of the amino acid sequence represented by UniProtKB:P35761-1. Example: UniProtKB:P35761-1, Thr-284, MOD:00047|Ser-287, MOD:00046." [PMID:21183079, PRO:HJD]


organism-gene



PR:P54199

serine/threonine-protein kinase MPS1 (yeast)

yTTK


"A dual specificity protein kinase TTK that is encoded in the genome of yeast." [PMID:22521787, PMID:8688079, PRO:KER]

Yes

organism-gene



PR:Q8AYG3

dual specificity protein kinase Ttk (zebrafish)

z-TTK


"A dual specificity protein kinase TTK that is encoded in the genome of zebrafish." [OMA:Q8AYG3, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000045754 hTTK/Phos:1
Example: UniProtKB:P33981-1, Thr-676, MOD:00047
acts_upstream_of_or_withinGO:0046777 protein autophosphorylation PMID:18680479; PMID:19120698
GO:0051298 centrosome duplication PMID:17728254
GO:0071174 mitotic spindle checkpoint signaling PMID:18083840
enablesGO:0004672 protein kinase activity PMID:18680479
PR:000049844 hTTK/(Act-loop)Phos+
Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)
acts_upstream_of_or_withinGO:0046777 protein autophosphorylation PMID:18680479; PMID:19120698
enablesGO:0004672 protein kinase activity PMID:18680479; PMID:19120698
PR:000049845 hTTK/(Act-loop_P+1-loop)Phos+
Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047
enablesGO:0004672 protein kinase activity PMID:19120698
PR:P33981 hTTK acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:20624902
GO:0032092 positive regulation of protein binding PMID:22660415
GO:0032092 positive regulation of protein binding PMID:22660415
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
NOT GO:0034501 protein localization to kinetochore PMID:20624902
GO:0045841 negative regulation of mitotic metaphase/anaphase transition PMID:20624902
GO:0051310 metaphase chromosome alignment PMID:20624902; PMID:22732840
enablesGO:0005515 protein binding with PR:Q12834 CDC20 BioGRID:BG-590746
located_inGO:0000776 kinetochore PMID:20624902
PR:P54199 yTTK acts_upstream_of_or_withinGO:0031577 spindle checkpoint signaling PMID:8688079
GO:0034501 protein localization to kinetochore PMID:22521787
GO:0034501 protein localization to kinetochore PMID:22521787
enablesGO:0004672 protein kinase activity PMID:22521787; PMID:8688079