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Protein Ontology report - tumor protein 63
PR:000016567 - http://purl.obolibrary.org/obo/PR_000016567
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000016567   
  PRO nametumor protein 63 
  Synonyms
PRO-Short-label: EXACT:TP63
Gene-based: RELATED:KET | P73H | P73L | TP73L | Trp63
Other: EXACT:chronic ulcerative stomatitis protein | CUSP | keratinocyte transcription factor KET | p73L | transformation-related protein 63 | tumor protein p73-like
  Definition"A protein that is a translation product of the human TP63 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence6                                                  Organism-Sequence 27                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000016567

tumor protein 63

TP63


"A protein that is a translation product of the human TP63 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O88898

tumor protein 63 (mouse)

mTP63


"A tumor protein 63 that is encoded in the genome of mouse." [OMA:O88898, PRO:DNx]


organism-seqgroup



PR:000044373

tumor protein 63 DeltaN isoform (mouse)

mTP63/iso:DeltaN


"A tumor protein 63 (mouse) that encodes any of the DeltaN splice variants." [PMID:17079275, PRO:KRC]

Yes





PR:O88898-2

tumor protein 63 isoform 2 (mouse)











PR:O88898-4

tumor protein 63 isoform 4 (mouse)











PR:O88898-6

tumor protein 63 isoform 6 (mouse)







organism-seqgroup



PR:000044374

tumor protein 63 TA isoform (mouse)

mTP63/iso:TA


"A tumor protein 63 (mouse) that encodes any of the TA splice variants." [PMID:17079275, PRO:KRC]






PR:O88898-1

tumor protein 63 isoform 1 (mouse)











PR:O88898-3

tumor protein 63 isoform 3 (mouse)











PR:O88898-5

tumor protein 63 isoform 5 (mouse)







organism-sequence



PR:O88898-1

tumor protein 63 isoform 1 (mouse)

mTP63/iso:1


"A tumor protein 63 isoform 1 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]

Yes

organism-sequence



PR:O88898-2

tumor protein 63 isoform 2 (mouse)

mTP63/iso:2


"A tumor protein 63 isoform 2 that is encoded in the genome of mouse." [PMID:17079275, PMID:9703973, PMID:9774969, PRO:HJD, PRO:KRC]

Yes

organism-sequence



PR:O88898-3

tumor protein 63 isoform 3 (mouse)

mTP63/iso:3


"A tumor protein 63 isoform 3 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


organism-sequence



PR:O88898-4

tumor protein 63 isoform 4 (mouse)

mTP63/iso:4


"A tumor protein 63 isoform 4 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


organism-sequence



PR:O88898-5

tumor protein 63 isoform 5 (mouse)

mTP63/iso:5


"A tumor protein 63 isoform 5 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


organism-sequence



PR:O88898-6

tumor protein 63 isoform 6 (mouse)

mTP63/iso:6


"A tumor protein 63 isoform 6 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


organism-gene



PR:Q9H3D4

tumor protein 63 (human)

hTP63


"A tumor protein 63 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-1

tumor protein 63 isoform 1 (human)

hTP63/iso:1


"A tumor protein 63 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9H3D4-10

tumor protein 63 isoform h10 (human)

hTP63/iso:h10


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-10." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-11

tumor protein 63 isoform h11 (human)

hTP63/iso:h11


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-11." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-12

tumor protein 63 isoform h12 (human)

hTP63/iso:h12


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-12." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-2

tumor protein 63 isoform 2 (human)

hTP63/iso:2


"A tumor protein 63 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9H3D4-3

tumor protein 63 isoform 3 (human)

hTP63/iso:3


"A tumor protein 63 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9H3D4-4

tumor protein 63 isoform 4 (human)

hTP63/iso:4


"A tumor protein 63 isoform 4 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9H3D4-5

tumor protein 63 isoform h5 (human)

hTP63/iso:h5


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-5." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-6

tumor protein 63 isoform h6 (human)

hTP63/iso:h6


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-6." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-7

tumor protein 63 isoform h7 (human)

hTP63/iso:h7


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-7." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-8

tumor protein 63 isoform h8 (human)

hTP63/iso:h8


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-8." [PRO:DNx, UniProtKB:Q9H3D4]


organism-sequence



PR:Q9H3D4-9

tumor protein 63 isoform h9 (human)

hTP63/iso:h9


"A tumor protein 63 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H3D4-9." [PRO:DNx, UniProtKB:Q9H3D4]


organism-modification



PR:000070189

tumor protein 63 phosphorylated 1 (human)

hTP63/Phos:1


"A tumor protein 63 (human) that has been phosphorylated on the residue at the position equivalent to Ser-612 of the amino acid sequence represented by UniProtKB:Q9H3D4-1. Example: UniProtKB:Q9H3D4-1, Ser-612, MOD:00046." [IEDB_epitope:608639, PRO:DNx]


organism-modification



PR:000075035

tumor protein 63 methylated 1 (human)

hTP63/Me:1


"A tumor protein 63 (human) that has been methylated on the residue at the position equivalent to Cys-14 of the amino acid sequence represented by UniProtKB:Q9H3D4-1. Example: UniProtKB:Q9H3D4-1, Cys-14, MOD:00660." [IEDB_epitope:1004131, PRO:DNx]


organism-gene



PR:Q9JJP6

tumor protein 63 (rat)

rTP63


"A tumor protein 63 that is encoded in the genome of rat." [OMA:Q9JJP6, PRO:DNx]


organism-sequence



PR:Q9JJP6-1

tumor protein 63 isoform r1 (rat)

rTP63/iso:r1


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-1." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-2

tumor protein 63 isoform r2 (rat)

rTP63/iso:r2


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-2." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-3

tumor protein 63 isoform r3 (rat)

rTP63/iso:r3


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-3." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-4

tumor protein 63 isoform r4 (rat)

rTP63/iso:r4


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-4." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-5

tumor protein 63 isoform r5 (rat)

rTP63/iso:r5


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-5." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-6

tumor protein 63 isoform r6 (rat)

rTP63/iso:r6


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-6." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-7

tumor protein 63 isoform r7 (rat)

rTP63/iso:r7


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-7." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-8

tumor protein 63 isoform r8 (rat)

rTP63/iso:r8


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-8." [PRO:DNx, UniProtKB:Q9JJP6]


organism-sequence



PR:Q9JJP6-9

tumor protein 63 isoform r9 (rat)

rTP63/iso:r9


"A tumor protein 63 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJP6-9." [PRO:DNx, UniProtKB:Q9JJP6]


sequence



PR:000035582

tumor protein 63 isoform 1

TP63/iso:1


"A tumor protein 63 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88898-1 or a 1:1 ortholog thereof. This form is produced by alternative promoter usage." [PMID:9774969, PRO:HJD]


organism-sequence



PR:O88898-1

tumor protein 63 isoform 1 (mouse)

mTP63/iso:1


"A tumor protein 63 isoform 1 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]

Yes

organism-sequence



PR:Q9H3D4-1

tumor protein 63 isoform 1 (human)

hTP63/iso:1


"A tumor protein 63 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000035584

tumor protein 63 isoform 2

TP63/iso:2


"A tumor protein 63 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88898-2 or a 1:1 ortholog thereof. This form is produced by alternative promoter usage." [PMID:9703973, PMID:9774969, PRO:HJD]


organism-sequence



PR:O88898-2

tumor protein 63 isoform 2 (mouse)

mTP63/iso:2


"A tumor protein 63 isoform 2 that is encoded in the genome of mouse." [PMID:17079275, PMID:9703973, PMID:9774969, PRO:HJD, PRO:KRC]

Yes

organism-sequence



PR:Q9H3D4-2

tumor protein 63 isoform 2 (human)

hTP63/iso:2


"A tumor protein 63 isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000035586

tumor protein 63 isoform 3

TP63/iso:3


"A tumor protein 63 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88898-3 or a 1:1 ortholog thereof. This form is produced by alterantive splicing of isoform 1." [PMID:9774969, PRO:HJD]


organism-sequence



PR:O88898-3

tumor protein 63 isoform 3 (mouse)

mTP63/iso:3


"A tumor protein 63 isoform 3 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


organism-sequence



PR:Q9H3D4-3

tumor protein 63 isoform 3 (human)

hTP63/iso:3


"A tumor protein 63 isoform 3 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000035588

tumor protein 63 isoform 4

TP63/iso:4


"A tumor protein 63 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88898-4 or a 1:1 ortholog thereof. This form is produced by alterantive splicing of isoform 2." [PMID:9774969, PRO:HJD]


organism-sequence



PR:O88898-4

tumor protein 63 isoform 4 (mouse)

mTP63/iso:4


"A tumor protein 63 isoform 4 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


organism-sequence



PR:Q9H3D4-4

tumor protein 63 isoform 4 (human)

hTP63/iso:4


"A tumor protein 63 isoform 4 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000035590

tumor protein 63 isoform 5

TP63/iso:5


"A tumor protein 63 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88898-5 or a 1:1 ortholog thereof. This form is produced by alterantive splicing of isoform 1." [PMID:9774969, PRO:HJD]


organism-sequence



PR:O88898-5

tumor protein 63 isoform 5 (mouse)

mTP63/iso:5


"A tumor protein 63 isoform 5 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


sequence



PR:000035592

tumor protein 63 isoform 6

TP63/iso:6


"A tumor protein 63 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88898-6 or a 1:1 ortholog thereof. This form is produced by alterantive splicing of isoform 2." [PMID:9774969, PRO:HJD]


organism-sequence



PR:O88898-6

tumor protein 63 isoform 6 (mouse)

mTP63/iso:6


"A tumor protein 63 isoform 6 that is encoded in the genome of mouse." [PMID:17079275, PMID:9774969, PRO:HJD, PRO:KRC]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044373 mTP63/iso:DeltaN acts_upstream_of_or_withinGO:0002053 positive regulation of mesenchymal cell proliferation MGI_ref:3703103; PMID:17079275
GO:0043066 negative regulation of apoptotic process MGI_ref:3703103; PMID:17079275
GO:0048745 smooth muscle tissue development MGI_ref:3703103; PMID:17079275
GO:0060157 urinary bladder development MGI_ref:3703103; PMID:17079275
PR:O88898-1 mTP63/iso:1 acts_upstream_of_or_withinGO:0008544 epidermis development MGI_ref:3761221; PMID:16601749
located_inGO:0005634 nucleus MGI_ref:3761221; PMID:16601749
PR:O88898-2 mTP63/iso:2 acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II MGI_ref:3623698; PMID:16618808
GO:0000122 negative regulation of transcription by RNA polymerase II MGI_ref:3623698; PMID:16618808
GO:0002064 epithelial cell development MGI_ref:3761221; PMID:16601749
GO:0008544 epidermis development MGI_ref:3761221; PMID:16601749
GO:0043616 keratinocyte proliferation MGI_ref:3761221; PMID:16601749
GO:0045617 negative regulation of keratinocyte differentiation MGI_ref:3623698; PMID:16618808
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:3794467; PMID:18326838
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:3794467; PMID:18326838
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:3794467; PMID:18326838
GO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:3794467; PMID:18326838
enablesGO:0003682 chromatin binding MGI_ref:3761221; PMID:16601749
GO:0043565 sequence-specific DNA binding MGI_ref:3794467; PMID:18326838
GO:0043565 sequence-specific DNA binding MGI_ref:3794467; PMID:18326838
located_inGO:0005634 nucleus MGI_ref:3761221; PMID:16601749