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Protein Ontology report - type 1B DNA topoisomerase 1
PR:000016542 - http://purl.obolibrary.org/obo/PR_000016542
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000016542   
  PRO nametype 1B DNA topoisomerase 1 
  Synonyms
PRO-Short-label: EXACT:TOP1
Gene-based: RELATED:Top-1
Other: DNA topoisomerase I (BROAD)
  Definition"A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2636
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000016542
type 1B DNA topoisomerase 1
TOP1
"A protein that is a translation product of the human TOP1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P11387
DNA topoisomerase 1 (human)
hTOP1
"A type 1B DNA topoisomerase 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11387]

organism-modification


PR:000049508
DNA topoisomerase 1, initiator methionine removed form (human)
hTOP1/InitMet-
"A DNA topoisomerase 1 (human) that has had the initiator methionine removed. UniProtKB:P11387, 2-765." [PRO:DNx, Reactome:R-HSA-4641363]

organism-modification


PR:000049509
DNA topoisomerase 1, initiator methionine removed sumoylated 1 (human)
hTOP1/InitMet-/Sumo:1
"A DNA topoisomerase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include sumoylated lysine at position 117 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, 2-765, Lys-117, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641364]

organism-modification


PR:000066763
DNA topoisomerase 1 deaminated 1 (human)
hTOP1/Deam:1
"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-601 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Gln-601, MOD:00685." [IEDB_epitope:1313507, PRO:DNx]

organism-modification


PR:000069264
DNA topoisomerase 1 deaminated 2 (human)
hTOP1/Deam:2
"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-611 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-611, MOD:00684." [IEDB_epitope:1332910, PRO:DNx]

organism-modification


PR:000069839
DNA topoisomerase 1 deaminated 3 (human)
hTOP1/Deam:3
"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-620 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-620, MOD:00684." [IEDB_epitope:1357057, PRO:DNx]

organism-modification


PR:000071666
DNA topoisomerase 1 deaminated 4 (human)
hTOP1/Deam:4
"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-296 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-296, MOD:00684." [IEDB_epitope:1312361, PRO:DNx]

organism-modification


PR:000073654
DNA topoisomerase 1 deaminated 5 (human)
hTOP1/Deam:5
"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-600 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Gln-600, MOD:00685." [IEDB_epitope:1312137, IEDB_epitope:1313851, PRO:DNx]

organism-modification


PR:000076794
DNA topoisomerase 1 deaminated 6 (human)
hTOP1/Deam:6
"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Gln-599 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Gln-599, MOD:00685." [IEDB_epitope:1312136, IEDB_epitope:1313506, PRO:DNx]

organism-modification


PR:000079112
DNA topoisomerase 1 phosphorylated 1 (human)
hTOP1/Phos:1
"A DNA topoisomerase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-667 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Ser-667, MOD:00046." [IEDB_epitope:2148795, PRO:DNx]

organism-modification


PR:000081429
DNA topoisomerase 1 hydroxylated 1 (human)
hTOP1/Hy:1
"A DNA topoisomerase 1 (human) that has been hydroxylated on the residue at the position equivalent to Lys-248 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Lys-248, MOD:00681." [IEDB_epitope:1328915, PRO:DNx]

organism-modification


PR:000084472
DNA topoisomerase 1 deaminated 7 (human)
hTOP1/Deam:7
"A DNA topoisomerase 1 (human) that has been deaminated on the residue at the position equivalent to Asn-539 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, Asn-539, MOD:00684." [IEDB_epitope:1575969, PRO:DNx]

organism-gene


PR:P30189
DNA topoisomerase 1 (fruit fly)
fly-TOP1
"A type 1B DNA topoisomerase 1 that is encoded in the genome of fruit fly." [OMA:P30189, PRO:DNx]

organism-gene


PR:Q04750
DNA topoisomerase 1 (mouse)
mTOP1
"A type 1B DNA topoisomerase 1 that is encoded in the genome of mouse." [OMA:Q04750, PRO:DNx]

organism-sequence


PR:Q04750-1
DNA topoisomerase 1 isoform 1 (mouse)
mTOP1/iso:1
"A type 1B DNA topoisomerase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-gene


PR:Q9WUL0
DNA topoisomerase 1 (rat)
rTOP1
"A type 1B DNA topoisomerase 1 that is encoded in the genome of rat." [OMA:Q9WUL0, PRO:DNx]

organism-sequence


PR:Q9WUL0-1
DNA topoisomerase 1 isoform 1 (rat)
rTOP1/iso:1
"A type 1B DNA topoisomerase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]

sequence


PR:000040273
type 1B DNA topoisomerase 1 isoform 1
TOP1/iso:1
"A type 1B DNA topoisomerase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04750-1 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:Q04750-1
DNA topoisomerase 1 isoform 1 (mouse)
mTOP1/iso:1
"A type 1B DNA topoisomerase 1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-sequence


PR:Q9WUL0-1
DNA topoisomerase 1 isoform 1 (rat)
rTOP1/iso:1
"A type 1B DNA topoisomerase 1 isoform 1 that is encoded in the genome of rat." [PRO:DNx]

modification


PR:000021719
type 1B DNA topoisomerase 1, initiator methionine removed form
TOP1/InitMet-
"A type 1B DNA topoisomerase 1 that has had the initiator methionine removed." [PRO:DNx]

organism-modification


PR:000049508
DNA topoisomerase 1, initiator methionine removed form (human)
hTOP1/InitMet-
"A DNA topoisomerase 1 (human) that has had the initiator methionine removed. UniProtKB:P11387, 2-765." [PRO:DNx, Reactome:R-HSA-4641363]

organism-modification


PR:000049509
DNA topoisomerase 1, initiator methionine removed sumoylated 1 (human)
hTOP1/InitMet-/Sumo:1
"A DNA topoisomerase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include sumoylated lysine at position 117 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, 2-765, Lys-117, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641364]