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Protein Ontology report - serine palmitoyltransferase 2
PR:000015597 - http://purl.obolibrary.org/obo/PR_000015597
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000015597   
  PRO nameserine palmitoyltransferase 2 
  Synonyms
PRO-Short-label: EXACT:SPTLC2
Gene-based: RELATED:KIAA0526 | LCB2
Other: EXACT:LCB 2 | LCB2a | long chain base biosynthesis protein 2 | long chain base biosynthesis protein 2a | serine-palmitoyl-CoA transferase 2 | SPT 2
  Definition"A eukaryotic serine palmitoyltransferase that is a translation product of the human SPTLC2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000026126 eukaryotic serine palmitoyltransferase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2510
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000015597 serine palmitoyltransferase 2
SPTLC2

organism-gene


PR:O15270 serine palmitoyltransferase 2 (human)
hSPTLC2

Yes
organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human)
hSPTLC2/iso:1

organism-modification


PR:000049342 serine palmitoyltransferase 2 pyridoxal phosphate lysine-containing 1 (human)
hSPTLC2/Pyrdox:1

organism-modification


PR:000073274 serine palmitoyltransferase 2 methylated 1 (human)
hSPTLC2/Me:1

organism-modification


PR:000083083 serine palmitoyltransferase 2 methylated 2 (human)
hSPTLC2/Me:2

organism-gene


PR:P97363 serine palmitoyltransferase 2 (mouse)
mSPTLC2
Yes
Yes
organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse)
mSPTLC2/iso:1
Yes
organism-gene


PR:Q3B7D2 serine palmitoyltransferase 2 (rat)
rSPTLC2

sequence


PR:000022020 serine palmitoyltransferase 2 isoform 1
SPTLC2/iso:1

organism-sequence


PR:O15270-1 serine palmitoyltransferase 2 isoform 1 (human)
hSPTLC2/iso:1

organism-sequence


PR:P97363-1 serine palmitoyltransferase 2 isoform 1 (mouse)
mSPTLC2/iso:1
Yes
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SPTLC2 forms found in complexes   

SPTLC2 Component
 Complexes
PR:O15270 hSPTLC2 PR:000026144 serine palmitoyltransferase complex core 1 (human)
PR:000026153 serine palmitoyltransferase complex 5 (human)
PR:000026154 serine palmitoyltransferase complex 6 (human)
PR:000026155 serine palmitoyltransferase complex A (human)
PR:P97363 mSPTLC2 PR:000025761 serine palmitoyltransferase complex (mouse)
PR:000025762 serine palmitoyltransferase complex A (mouse)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006686 sphingomyelin biosynthetic processPR:P97363 mSPTLC2 PMID:16216550
GO:0046511 sphinganine biosynthetic processPR:P97363-1 mSPTLC2/iso:1 PMID:9363775
GO:0046512 sphingosine biosynthetic processPR:P97363 mSPTLC2 PMID:16216550
GO:0046513 ceramide biosynthetic processPR:P97363 mSPTLC2 PMID:16216550

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004758 serine C-palmitoyltransferase activityPR:P97363-1 mSPTLC2/iso:1 PMID:9363775

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005739 mitochondrionPR:P97363-1 mSPTLC2/iso:1 PMID:18614015