back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - solute carrier family 12 member 1
PR:000014924 - http://purl.obolibrary.org/obo/PR_000014924
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014924   
  PRO namesolute carrier family 12 member 1 
  Synonyms
PRO-Short-label: EXACT:SLC12A1
Gene-based: RELATED:NKCC2
Other: EXACT:BSC1 | bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 | kidney-specific Na-K-Cl symporter | Na-K-2Cl cotransporter 2
  Definition"A protein that is a translation product of the human SLC12A1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
IUPHARobj:968
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000014924

solute carrier family 12 member 1

SLC12A1


"A protein that is a translation product of the human SLC12A1 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P55014

solute carrier family 12 member 1 (mouse)

mSLC12A1


"A solute carrier family 12 member 1 that is encoded in the genome of mouse." [OMA:P55014, PRO:DNx]


organism-sequence



PR:P55014-1

solute carrier family 12 member 1 isoform A (mouse)

mSlc12a1/iso:A


"A solute carrier family 12 member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55014-1." [PRO:DNx, UniProtKB:P55014]

Yes

organism-sequence



PR:P55014-2

solute carrier family 12 member 1 isoform A4 (mouse)

mSlc12a1/iso:A4


"A solute carrier family 12 member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55014-2." [PRO:DNx, UniProtKB:P55014]


organism-sequence



PR:P55014-3

solute carrier family 12 member 1 isoform B (mouse)

mSlc12a1/iso:B


"A solute carrier family 12 member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55014-3." [PRO:DNx, UniProtKB:P55014]


organism-sequence



PR:P55014-4

solute carrier family 12 member 1 isoform F (mouse)

mSlc12a1/iso:F


"A solute carrier family 12 member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55014-4." [PRO:DNx, UniProtKB:P55014]

Yes

organism-gene



PR:P55016

solute carrier family 12 member 1 (rat)

rSLC12A1


"A solute carrier family 12 member 1 that is encoded in the genome of rat." [OMA:P55016, PRO:DNx]


organism-gene



PR:Q13621

solute carrier family 12 member 1 (human)

hSLC12A1


"A solute carrier family 12 member 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13621]


organism-sequence



PR:000061002

solute carrier family 12 member 1 sequence variant G319R (human)

hSLC12A1/var:G319R


"A solute carrier family 12 member 1 (human) that has an Arg residue at the position equivalent to Gly-319 of the amino acid sequence represented by UniProtKB:Q13621-1. Example: UniProtKB:Q13621-1, Gly-319, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-5623607]


organism-sequence



PR:000062019

solute carrier family 12 member 1 sequence variant R302Q (human)

hSLC12A1/var:R302Q


"A solute carrier family 12 member 1 (human) that has a Gln residue at the position equivalent to Arg-302 of the amino acid sequence represented by UniProtKB:Q13621-1. Example: UniProtKB:Q13621-1, Arg-302, CHEBI:30011." [PRO:DNx, Reactome:R-HSA-5623568]


organism-sequence



PR:000062587

solute carrier family 12 member 1 sequence variant G278F (human)

hSLC12A1/var:G278F


"A solute carrier family 12 member 1 (human) that has a Phe residue at the position equivalent to Gly-278 of the amino acid sequence represented by UniProtKB:Q13621-1. Example: UniProtKB:Q13621-1, Gly-278, CHEBI:29997." [PRO:DNx, Reactome:R-HSA-5623585]


organism-sequence



PR:000064376

solute carrier family 12 member 1 sequence variant D648N (human)

hSLC12A1/var:D648N


"A solute carrier family 12 member 1 (human) that has an Asn residue at the position equivalent to Asp-648 of the amino acid sequence represented by UniProtKB:Q13621-1. Example: UniProtKB:Q13621-1, Asp-648, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-5623595]


organism-sequence



PR:Q13621-1

solute carrier family 12 member 1 isoform A (human)

hSLC12A1/iso:A


"A solute carrier family 12 member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13621-1." [PRO:DNx, UniProtKB:Q13621]


organism-sequence



PR:Q13621-2

solute carrier family 12 member 1 isoform B (human)

hSLC12A1/iso:B


"A solute carrier family 12 member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13621-2." [PRO:DNx, UniProtKB:Q13621]


organism-sequence



PR:Q13621-3

solute carrier family 12 member 1 isoform F (human)

hSLC12A1/iso:F


"A solute carrier family 12 member 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13621-3." [PRO:DNx, UniProtKB:Q13621]


Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P55014-1 mSlc12a1/iso:A acts_upstream_of_or_withinGO:0070886 positive regulation of calcineurin-NFAT signaling cascade MGI_ref:4947009; PMID:21228109
GO:0071475 cellular hyperosmotic salinity response MGI_ref:4947009; PMID:21228109
PR:P55014-4 mSlc12a1/iso:F enablesGO:0005515 protein binding with PR:000044370|PR:G1JLS7|PR:Q9Z1W9-1 MGI_ref:5538439; PMID:24133122
GO:0008511 sodium:potassium:chloride symporter activity MGI_ref:5538439; PMID:24133122