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Protein Ontology report - NAD-dependent protein deacetylase sirtuin-1
PR:000014888 - http://purl.obolibrary.org/obo/PR_000014888
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000014888   
  PRO nameNAD-dependent protein deacetylase sirtuin-1 
  Synonyms
PRO-Short-label: EXACT:SIRT1
Gene-based: RELATED:SIR2L1
Other: EXACT:NAD-dependent deacetylase sirtuin-1 | NAD-dependent protein deacylase sirtuin-1 | regulatory protein SIR2 homolog 1 | sir2 | SIR2-like protein 1 | SIR2a | SIR2alpha
  Definition"A protein that is a translation product of the human SIRT1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 4                                        
         Modification1                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2707
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000014888
NAD-dependent protein deacetylase sirtuin-1
SIRT1
"A protein that is a translation product of the human SIRT1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:A0A0G2JZ79
NAD-dependent protein deacetylase sirtuin-1 (rat)
rSIRT1
"An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of rat." [OMA:A0A0G2JZ79, PRO:DNx]

organism-gene


PR:Q923E4
NAD-dependent protein deacetylase sirtuin-1 (mouse)
mSIRT1
"An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of mouse." [OMA:Q923E4, PRO:DNx]

organism-sequence


PR:Q923E4-1
NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse)
mSIRT1/iso:m1
"An NAD-dependent protein deacetylase sirtuin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q923E4-1." [PRO:DNx, UniProtKB:Q923E4]

organism-modification


PR:000050034
NAD-dependent protein deacetylase sirtuin-1 isoform m1 phosphorylated 1 (mouse)
mSIRT1/iso:m1/Phos:1
"An NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse) that has been phosphorylated at Thr-522. UniProtKB:Q923E4-1, Thr-522, MOD:00047." [PMID:28364022, PRO:HJD]

organism-modification


PR:000050035
NAD-dependent protein deacetylase sirtuin-1 isoform m1 unphosphorylated 1 (mouse)
mSIRT1/iso:m1/UnPhos:1
"An NAD-dependent protein deacetylase sirtuin-1 isoform m1 (mouse) that lacks phosphorylation at Thr-522. UniProtKB:Q923E4-1, Thr-522, PR:000026291." [PMID:28364022, PRO:HJD]

organism-sequence


PR:Q923E4-2
NAD-dependent protein deacetylase sirtuin-1 isoform m2 (mouse)
mSIRT1/iso:m2
"An NAD-dependent protein deacetylase sirtuin-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q923E4-2." [PRO:DNx, UniProtKB:Q923E4]

organism-gene


PR:Q96EB6
NAD-dependent protein deacetylase sirtuin-1 (human)
hSIRT1
"An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96EB6]

organism-sequence


PR:Q96EB6-1
NAD-dependent protein deacetylase sirtuin-1 isoform h1 (human)
hSIRT1/iso:h1
"An NAD-dependent protein deacetylase sirtuin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96EB6-1." [PRO:DNx, UniProtKB:Q96EB6]

organism-sequence


PR:Q96EB6-2
NAD-dependent protein deacetylase sirtuin-1 isoform h2 (human)
hSIRT1/iso:h2
"An NAD-dependent protein deacetylase sirtuin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96EB6-2." [PRO:DNx, UniProtKB:Q96EB6]

organism-modification


PR:000049252
NAD-dependent protein deacetylase sirtuin-1, initiator methionine removed form (human)
hSIRT1/InitMet-
"An NAD-dependent protein deacetylase sirtuin-1 (human) that has had the initiator methionine removed. UniProtKB:Q96EB6, 2-747." [PRO:DNx, Reactome:R-HSA-427531]

organism-modification


PR:000083724
NAD-dependent protein deacetylase sirtuin-1 methylated 1 (human)
hSIRT1/Me:1
"An NAD-dependent protein deacetylase sirtuin-1 (human) that has been methylated on the residue at the position equivalent to Cys-490 of the amino acid sequence represented by UniProtKB:Q96EB6-1. Example: UniProtKB:Q96EB6-1, Cys-490, MOD:00660." [IEDB_epitope:1020807, PRO:DNx]

modification


PR:000021480
NAD-dependent protein deacetylase sirtuin-1, initiator methionine removed form
SIRT1/InitMet-
"An NAD-dependent protein deacetylase sirtuin-1 that has had the initiator methionine removed." [PRO:DNx]

organism-modification


PR:000049252
NAD-dependent protein deacetylase sirtuin-1, initiator methionine removed form (human)
hSIRT1/InitMet-
"An NAD-dependent protein deacetylase sirtuin-1 (human) that has had the initiator methionine removed. UniProtKB:Q96EB6, 2-747." [PRO:DNx, Reactome:R-HSA-427531]