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Protein Ontology report - E3 ubiquitin-protein ligase SIAH1
PR:000014860 - http://purl.obolibrary.org/obo/PR_000014860
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014860   
  PRO nameE3 ubiquitin-protein ligase SIAH1 
  Synonyms
PRO-Short-label: EXACT:SIAH1
Gene-based: RELATED:HUMSIAH
Other: EXACT:seven in absentia homolog 1 | seven in absentia homolog 1a | Siah-1 | Siah-1a
  Definition"A protein that is a translation product of the human SIAH1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification1                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000014860
E3 ubiquitin-protein ligase SIAH1
SIAH1
"A protein that is a translation product of the human SIAH1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P21461
E3 ubiquitin-protein ligase sina (fruit fly)
fly-SIAH1
"An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of fruit fly." [OMA:P21461, PRO:DNx]

organism-gene


PR:P61092
E3 ubiquitin-protein ligase SIAH1A (mouse)
mSIAH1
"An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of mouse." [OMA:P61092, PRO:DNx]

organism-sequence


PR:P61092-1
E3 ubiquitin-protein ligase SIAH1A isoform 1 (mouse)
mSIAH1/iso:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-gene


PR:Q7ZVG6
E3 ubiquitin-protein ligase Siah1 (zebrafish)
z-SIAH1
"An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of zebrafish." [OMA:Q7ZVG6, PRO:DNx]

organism-gene


PR:Q8IUQ4
E3 ubiquitin-protein ligase SIAH1 (human)
hSIAH1
"An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IUQ4]

organism-sequence


PR:Q8IUQ4-1
E3 ubiquitin-protein ligase SIAH1 isoform 1 (human)
hSIAH1/iso:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000025641
E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)
hSIAH1/iso:1/Phos:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 in human. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048." [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]
Yes
organism-modification


PR:000045369
E3 ubiquitin-protein ligase SIAH1 isoform 1 unphosphorylated 1 (human)
hSIAH1/iso:1/UnPhos:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 (human) that lacks phosphorylation at Tyr-100 and Tyr-126. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291." [PRO:JAN]
Yes
organism-sequence


PR:Q8IUQ4-2
E3 ubiquitin-protein ligase SIAH1 isoform h2 (human)
hSIAH1/iso:h2
"An E3 ubiquitin-protein ligase SIAH1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUQ4-2." [PRO:DNx, UniProtKB:Q8IUQ4]

organism-sequence


PR:Q8IUQ4-3
E3 ubiquitin-protein ligase SIAH1 isoform h3 (human)
hSIAH1/iso:h3
"An E3 ubiquitin-protein ligase SIAH1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUQ4-3." [PRO:DNx, UniProtKB:Q8IUQ4]

organism-modification


PR:000069106
E3 ubiquitin-protein ligase SIAH1 deaminated 1 (human)
hSIAH1/Deam:1
"An E3 ubiquitin-protein ligase SIAH1 (human) that has been deaminated on the residue at the position equivalent to Gln-265 of the amino acid sequence represented by UniProtKB:Q8IUQ4-1. Example: UniProtKB:Q8IUQ4-1, Gln-265, MOD:00685." [IEDB_epitope:1591942, PRO:DNx]

organism-gene


PR:Q920M9
E3 ubiquitin-protein ligase SIAH1 (rat)
rSIAH1
"An E3 ubiquitin-protein ligase SIAH1 that is encoded in the genome of rat." [OMA:Q920M9, PRO:DNx]

organism-sequence


PR:Q920M9-1
E3 ubiquitin-protein ligase SIAH1 isoform 1 (rat)
rSIAH1/iso:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]
Yes
sequence


PR:000025622
E3 ubiquitin-protein ligase SIAH1 isoform 1
SIAH1/iso:1
"An E3 ubiquitin-protein ligase SIAH1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IUQ4-1 or a 1:1 ortholog thereof." [PRO:CNA]

organism-sequence


PR:P61092-1
E3 ubiquitin-protein ligase SIAH1A isoform 1 (mouse)
mSIAH1/iso:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-sequence


PR:Q8IUQ4-1
E3 ubiquitin-protein ligase SIAH1 isoform 1 (human)
hSIAH1/iso:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000025641
E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)
hSIAH1/iso:1/Phos:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 in human. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048." [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]
Yes
organism-modification


PR:000045369
E3 ubiquitin-protein ligase SIAH1 isoform 1 unphosphorylated 1 (human)
hSIAH1/iso:1/UnPhos:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 (human) that lacks phosphorylation at Tyr-100 and Tyr-126. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291." [PRO:JAN]
Yes
organism-sequence


PR:Q920M9-1
E3 ubiquitin-protein ligase SIAH1 isoform 1 (rat)
rSIAH1/iso:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]
Yes
modification


PR:000025627
E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1
SIAH1/iso:1/Phos:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 that has been phosphorylated on Tyr residues by activation of the JNK pathway. Example: UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048." [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]

organism-modification


PR:000025641
E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 (human)
hSIAH1/iso:1/Phos:1
"An E3 ubiquitin-protein ligase SIAH1 isoform 1 phosphorylated 1 in human. UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048." [PMID:16230351, PMID:9482736, PRO:DAN, PRO:JAN]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025641 hSIAH1/iso:1/Phos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, MOD:00048		 acts_upstream_of_or_withinGO:0043525 positive regulation of neuron apoptotic process PMID:16230351
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351
enablesincreased GO:0005515 protein binding with PR:Q69ZI1-1 PMID:16230351
PR:000045369 hSIAH1/iso:1/UnPhos:1
UniProtKB:Q8IUQ4-1, Tyr-100/Tyr-126, PR:000026291		 acts_upstream_of_or_withinGO:0043525 positive regulation of neuron apoptotic process PMID:16230351
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade PMID:16230351
enablesGO:0005515 protein binding with PR:Q69ZI1 Kiaa1494 PMID:16230351
PR:Q920M9-1 rSIAH1/iso:1 enablesGO:0005515 protein binding with PR:Q71F54 plenty of SH3s (rat) PMID:16230351