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Protein Ontology report - runt-related transcription factor 2
PR:000014364 - http://purl.obolibrary.org/obo/PR_000014364
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014364   
  PRO namerunt-related transcription factor 2 
  Synonyms
PRO-Short-label: EXACT:RUNX2
Gene-based: RELATED:AML3 | CBFA1 | OSF2 | PEBP2A
Other: EXACT:acute myeloid leukemia 3 protein | CBF-alpha-1 | core-binding factor subunit alpha-1 | oncogene AML-3 | osteoblast-specific transcription factor 2 | PEA2-alpha A | PEBP2-alpha A | polyomavirus enhancer-binding protein 2 alpha A subunit | SL3-3 enhancer factor 1 alpha A subunit | SL3/AKV core-binding factor alpha A subunit
RELATED:OSF-2
  Definition"A protein that is a translation product of the human RUNX2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 12                                        
         Modification0                                                  Organism-Modification 16                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000014364

runt-related transcription factor 2

RUNX2


"A protein that is a translation product of the human RUNX2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q08775

runt-related transcription factor 2 (mouse)

mRUNX2


"A runt-related transcription factor 2 that is encoded in the genome of mouse." [OMA:Q08775, PRO:DNx]


organism-sequence



PR:Q08775-1

runt-related transcription factor 2 isoform 1 (mouse)

mRUNX2/iso:1


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-1." [PMID:10524201, PRO:HJD]


organism-sequence



PR:Q08775-2

runt-related transcription factor 2 isoform 2 (mouse)

mRUNX2/iso:2


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-2." [PMID:9238031, PRO:HJD]


organism-sequence



PR:Q08775-3

runt-related transcription factor 2 isoform 3 (mouse)

mRUNX2/iso:3


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-3." [PMID:9238031, PRO:HJD]


organism-sequence



PR:Q08775-4

runt-related transcription factor 2 isoform 4 (mouse)

mRUNX2/iso:4


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-4." [PMID:9238031, PRO:HJD]


organism-sequence



PR:Q08775-5

runt-related transcription factor 2 isoform 5 (mouse)

mRUNX2/iso:5


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-5." [PMID:9238031, PRO:HJD]


organism-sequence



PR:Q08775-6

runt-related transcription factor 2 isoform 6 (mouse)

mRUNX2/iso:6


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-6." [PMID:9238031, PRO:HJD]


organism-sequence



PR:Q08775-7

runt-related transcription factor 2 isoform 7 (mouse)

mRUNX2/iso:7


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-7." [PMID:9238031, PRO:HJD]


organism-sequence



PR:Q08775-8

runt-related transcription factor 2 isoform 8 (mouse)

mRUNX2/iso:8


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-8." [PMID:9238031, PRO:HJD]

Yes

organism-sequence



PR:Q08775-9

runt-related transcription factor 2 isoform 9 (mouse)

mRUNX2/iso:9


"A runt-related transcription factor 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08775-9." [PMID:9238031, PRO:HJD]

Yes

organism-gene



PR:Q13950

runt-related transcription factor 2 (human)

hRUNX2


"A runt-related transcription factor 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13950]


organism-sequence



PR:Q13950-1

runt-related transcription factor 2 isoform h1 (human)

hRUNX2/iso:h1


"A runt-related transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13950-1." [PRO:DNx, UniProtKB:Q13950]


organism-modification



PR:000060799

runt-related transcription factor 2 isoform h1 phosphorylated 1 (human)

hRUNX2/iso:h1/Phos:1


"A runt-related transcription factor 2 isoform h1 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-294, Ser-298, and Ser-302 of the amino acid sequence represented by UniProtKB:Q13950-1. UniProtKB:Q13950-1, Ser-294/Ser-298/Ser-302, MOD:00046." [PRO:DNx, Reactome:R-HSA-9008535]


organism-modification



PR:000061206

runt-related transcription factor 2 isoform h1 phosphorylated 2 (human)

hRUNX2/iso:h1/Phos:2


"A runt-related transcription factor 2 isoform h1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-432 of the amino acid sequence represented by UniProtKB:Q13950-1. UniProtKB:Q13950-1, Ser-432, MOD:00046." [PRO:DNx, Reactome:R-HSA-9008852]


organism-modification



PR:000061349

runt-related transcription factor 2 isoform h1 phosphorylated 3 (human)

hRUNX2/iso:h1/Phos:3


"A runt-related transcription factor 2 isoform h1 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-294 and Ser-312 of the amino acid sequence represented by UniProtKB:Q13950-1. UniProtKB:Q13950-1, Ser-294/Ser-312, MOD:00046." [PRO:DNx, Reactome:R-HSA-9009188]


organism-modification



PR:000062012

runt-related transcription factor 2 isoform h1 phosphorylated 4 (human)

hRUNX2/iso:h1/Phos:4


"A runt-related transcription factor 2 isoform h1 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-196, Thr-198, and Thr-200 of the amino acid sequence represented by UniProtKB:Q13950-1. UniProtKB:Q13950-1, Ser-196, MOD:00046|Thr-198/Thr-200, MOD:00047." [PRO:DNx, Reactome:R-HSA-8939964]


organism-modification



PR:000062401

runt-related transcription factor 2 isoform h1 phosphorylated 5 (human)

hRUNX2/iso:h1/Phos:5


"A runt-related transcription factor 2 isoform h1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-465 of the amino acid sequence represented by UniProtKB:Q13950-1. UniProtKB:Q13950-1, Ser-465, MOD:00046." [PRO:DNx, Reactome:R-HSA-9008409]


organism-modification



PR:000064718

runt-related transcription factor 2 isoform h1 ubiquitinated form (human)

hRUNX2/iso:h1/UbiqLys+


"A runt-related transcription factor 2 isoform h1 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q13950-1, MOD:01148." [PRO:DNx, Reactome:R-HSA-9008082, Reactome:R-HSA-9008125]


organism-modification



PR:000064858

runt-related transcription factor 2 isoform h1 phosphorylated and ubiquitinated 1 (human)

hRUNX2/iso:h1/PhosUbiq:1


"A runt-related transcription factor 2 isoform h1 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-294, Ser-298, and Ser-302 of the amino acid sequence represented by UniProtKB:Q13950-1 and that includes at least one ubiquitinated lysine. UniProtKB:Q13950-1, Ser-294/Ser-298/Ser-302, MOD:00046|MOD:01148." [PRO:DNx]


organism-sequence



PR:Q13950-2

runt-related transcription factor 2 isoform h2 (human)

hRUNX2/iso:h2


"A runt-related transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13950-2." [PRO:DNx, UniProtKB:Q13950]


organism-modification



PR:000061936

runt-related transcription factor 2 isoform h2 phosphorylated 1 (human)

hRUNX2/iso:h2/Phos:1


"A runt-related transcription factor 2 isoform h2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-451 of the amino acid sequence represented by UniProtKB:Q13950-2. UniProtKB:Q13950-2, Ser-451, MOD:00046." [PRO:DNx, Reactome:R-HSA-9008422]


organism-modification



PR:000062350

runt-related transcription factor 2 isoform h2 phosphorylated 2 (human)

hRUNX2/iso:h2/Phos:2


"A runt-related transcription factor 2 isoform h2 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-280, Ser-284, and Ser-288 of the amino acid sequence represented by UniProtKB:Q13950-2. UniProtKB:Q13950-2, Ser-280/Ser-284/Ser-288, MOD:00046." [PRO:DNx, Reactome:R-HSA-9008543]


organism-modification



PR:000062391

runt-related transcription factor 2 isoform h2 phosphorylated 3 (human)

hRUNX2/iso:h2/Phos:3


"A runt-related transcription factor 2 isoform h2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-418 of the amino acid sequence represented by UniProtKB:Q13950-2. UniProtKB:Q13950-2, Ser-418, MOD:00046." [PRO:DNx, Reactome:R-HSA-9008847]


organism-modification



PR:000063344

runt-related transcription factor 2 isoform h2 phosphorylated 4 (human)

hRUNX2/iso:h2/Phos:4


"A runt-related transcription factor 2 isoform h2 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-280 and Ser-298 of the amino acid sequence represented by UniProtKB:Q13950-2. UniProtKB:Q13950-2, Ser-280/Ser-298, MOD:00046." [PRO:DNx, Reactome:R-HSA-9009192]


organism-modification



PR:000064486

runt-related transcription factor 2 isoform h2 phosphorylated 5 (human)

hRUNX2/iso:h2/Phos:5


"A runt-related transcription factor 2 isoform h2 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-182, Thr-184, and Thr-186 of the amino acid sequence represented by UniProtKB:Q13950-2. UniProtKB:Q13950-2, Ser-182, MOD:00046|Thr-184/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-9014875]


organism-modification



PR:000064695

runt-related transcription factor 2 isoform h2 phosphorylated and ubiquitinated 1 (human)

hRUNX2/iso:h2/PhosUbiq:1


"A runt-related transcription factor 2 isoform h2 (human) that has been phosphorylated on the residues at the positions equivalent to Ser-280, Ser-284, and Ser-288 of the amino acid sequence represented by UniProtKB:Q13950-2 and that includes at least one ubiquitinated lysine. UniProtKB:Q13950-2, Ser-280/Ser-284/Ser-288, MOD:00046|MOD:01148." [PRO:DNx]


organism-modification



PR:000064807

runt-related transcription factor 2 isoform h2 ubiquitinated form (human)

hRUNX2/iso:h2/UbiqLys+


"A runt-related transcription factor 2 isoform h2 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q13950-2, MOD:01148." [PRO:DNx, Reactome:R-HSA-9008086, Reactome:R-HSA-9008124]


organism-sequence



PR:Q13950-3

runt-related transcription factor 2 isoform h3 (human)

hRUNX2/iso:h3


"A runt-related transcription factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13950-3." [PRO:DNx, UniProtKB:Q13950]


organism-modification



PR:000066637

runt-related transcription factor 2 phosphorylated 1 (human)

hRUNX2/Phos:1


"A runt-related transcription factor 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-28 of the amino acid sequence represented by UniProtKB:Q13950-1. Example: UniProtKB:Q13950-1, Ser-28, MOD:00046." [IEDB_epitope:1369613, PRO:DNx]


organism-modification



PR:000073738

runt-related transcription factor 2 deaminated 1 (human)

hRUNX2/Deam:1


"A runt-related transcription factor 2 (human) that has been deaminated on the residue at the position equivalent to Gln-209 of the amino acid sequence represented by UniProtKB:Q13950-1. Example: UniProtKB:Q13950-1, Gln-209, MOD:00685." [IEDB_epitope:2143917, PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q08775-8 mRUNX2/iso:8 located_inGO:0005737 cytoplasm MGI_ref:3051083; PMID:15225881
PR:Q08775-9 mRUNX2/iso:9 located_inGO:0005737 cytoplasm MGI_ref:3051083; PMID:15225881