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Protein Ontology report - roundabout homolog 3
PR:000014153 - http://purl.obolibrary.org/obo/PR_000014153
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000014153   
  PRO nameroundabout homolog 3 
  Synonyms
PRO-Short-label: EXACT:ROBO3
Gene-based: RELATED:Rbig1
Other: EXACT:retinoblastoma-inhibiting gene 1 protein | Rig-1 | roundabout-like protein 3
  Definition"A ROBO protein that is a translation product of the human ROBO3 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000050051 ROBO protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 9                                        
         Modification0                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000014153

roundabout homolog 3

ROBO3


"A ROBO protein that is a translation product of the human ROBO3 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q96MS0

roundabout homolog 3 (human)

hROBO3


"A roundabout homolog 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96MS0]


organism-sequence



PR:F5GWJ5

roundabout homolog 3 isoform ROBO3B.1 (human)

hROBO3/iso:ROBO3B.1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of human." [PMID:16554811, PMID:19690332, PRO:CNA, UniProtKB:F5GWJ5]


organism-sequence



PR:Q96MS0-1

roundabout homolog 3 isoform ROBO3A.1 (human)

hROBO3/iso:ROBO3A.1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of human." [PMID:15105459, PRO:CNA, UniProtKB:Q96MS0]


organism-modification



PR:000060958

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed form (human)

hROBO3/iso:ROBO3A.1/SigPep-


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed. UniProtKB:Q96MS0-1, 21-1386." [PRO:DNx, Reactome:R-HSA-426410]


organism-modification



PR:000061592

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 1 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:1


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Ser-1330 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Ser-1330, MOD:00046." [PRO:DNx, Reactome:R-HSA-9010775]


organism-modification



PR:000062739

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 2 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:2


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-1019 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Tyr-1019, MOD:00048." [PRO:DNx, Reactome:R-HSA-9011239]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


organism-sequence



PR:Q96MS0-2

roundabout homolog 3 isoform h2 (human)

hROBO3/iso:h2


"A roundabout homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96MS0-2." [PRO:DNx, UniProtKB:Q96MS0]


organism-modification



PR:000081279

roundabout homolog 3 deaminated 1 (human)

hROBO3/Deam:1


"A roundabout homolog 3 (human) that has been deaminated on the residue at the position equivalent to Gln-697 of the amino acid sequence represented by UniProtKB:Q96MS0-1. Example: UniProtKB:Q96MS0-1, Gln-697, MOD:00685." [IEDB_epitope:2144025, PRO:DNx]


organism-gene



PR:Q9Z2I4

roundabout homolog 3 (mouse)

mROBO3


"A roundabout homolog 3 that is encoded in the genome of mouse." [OMA:Q9Z2I4, PRO:DNx]


seqgroup



PR:000037776

roundabout homolog 3 isoform ROBO3B (mouse)

mROBO3/iso:ROBO3B[1/2]


"A roundabout homolog 3 (mouse) that has a shorter N-terminal sequence than ROBO3A forms." [PMID:16226035, PMID:18466743, PRO:CNA]






PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)











PR:Q9Z2I4-2

roundabout homolog 3 isoform ROBO3B.2 (mouse)







organism-sequence



PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)

mROBO3/iso:ROBO3A1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of mouse. This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16226035, PRO:KRC, UniProtKB:D3Z4M6]

Yes

organism-sequence



PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)

mROBO3/iso:B1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of mouse. This isoform has a shorter N-terminal sequence in comparison with ROBO3A isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16554811, PMID:18466743, PRO:KRC]


organism-sequence



PR:Q9Z2I4-1

roundabout homolog 3 isoform ROBO3A.2 (mouse)

mROBO3/iso:ROBO3A.2


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-1. Isoforms ROBO3A have a longer N-terminal sequence than isoforms ROBO3B. Isoforms ROBO3.2 have a unique C-terminal sequence due to retention of the intron between exons 26 and 27." [PMID:16226035, PMID:18466743, PRO:KRC, UniProtKB:Q9Z2I4]


organism-sequence



PR:Q9Z2I4-2

roundabout homolog 3 isoform ROBO3B.2 (mouse)

mROBO3/iso:ROBO3B.2


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-2. Isoforms ROBO3B have a shorter N-terminal sequence than isoforms ROBO3A. Isoforms ROBO3.2 have a unique C-terminal sequence due to retention of the intron between exons 26 and 27." [PMID:10049565, PMID:16226035, PMID:18466743, PRO:KRC, UniProtKB:Q9Z2I4]


organism-sequence



PR:Q9Z2I4-3

roundabout homolog 3 isoform m1 (mouse)

mROBO3/iso:m1


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-3." [PRO:DNx, UniProtKB:Q9Z2I4]


organism-sequence



PR:Q9Z2I4-4

roundabout homolog 3 isoform m3 (mouse)

mROBO3/iso:m3


"A roundabout homolog 3 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z2I4-4." [PRO:DNx, UniProtKB:Q9Z2I4]


seqgroup



PR:000037775

roundabout homolog 3 isoform ROBO3A (mouse)

mROBO3/iso:ROBO3A[1/2]


"A roundabout homolog 3 (mouse) that has a longer N-terminal sequence than ROBO3B forms." [PMID:16226035, PMID:18466743, PRO:CNA]






PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)











PR:Q9Z2I4-1

roundabout homolog 3 isoform ROBO3A.2 (mouse)







seqgroup



PR:000037777

roundabout homolog 3 isoform ROBO3.1 (mouse)

mROBO3/iso:ROBO3[A/B]1


"A roundabout homolog 3 (mouse) that has a C-terminal sequence that includes the region encoded by exons 26, 27 and 28. The resulting 78 amino acid peptide is highly enriched in arginine/serine dipeptide repeats." [PMID:16554811, PMID:18466743, PRO:KRC]

Yes





PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)











PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)







seqgroup



PR:000037778

roundabout homolog 3 isoform ROBO3.2 (mouse)

mROBO3/iso:ROBO3[A/B]2


"A roundabout homolog 3 (mouse) that has a unique C-terminal sequence due to retention of the intron between exons 26 and 27." [PMID:16554811, PMID:18466743, PRO:KRC]

Yes





PR:Q9Z2I4-1

roundabout homolog 3 isoform ROBO3A.2 (mouse)











PR:Q9Z2I4-2

roundabout homolog 3 isoform ROBO3B.2 (mouse)







sequence



PR:000037773

roundabout homolog 3 isoform ROBO3A.1

ROBO3/iso:ROBO3A.1


"A roundabout homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96MS0-1 or a 1:1 ortholog thereof. Isoforms ROBO3A have a longer N-terminal sequence than isoforms ROBO3B. Isoforms ROBO3.1 have a C-terminal sequence highly enriched in arginine/serine dipeptide repeats." [PMID:15105459, PMID:16226035, PMID:18466743, PRO:CNA]


organism-sequence



PR:D3Z4M6

roundabout homolog 3 isoform ROBO3A.1 (mouse)

mROBO3/iso:ROBO3A1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of mouse. This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16226035, PRO:KRC, UniProtKB:D3Z4M6]

Yes

organism-sequence



PR:Q96MS0-1

roundabout homolog 3 isoform ROBO3A.1 (human)

hROBO3/iso:ROBO3A.1


"A roundabout homolog 3 isoform ROBO3A.1 that is encoded in the genome of human." [PMID:15105459, PRO:CNA, UniProtKB:Q96MS0]


organism-modification



PR:000060958

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed form (human)

hROBO3/iso:ROBO3A.1/SigPep-


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed. UniProtKB:Q96MS0-1, 21-1386." [PRO:DNx, Reactome:R-HSA-426410]


organism-modification



PR:000061592

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 1 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:1


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Ser-1330 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Ser-1330, MOD:00046." [PRO:DNx, Reactome:R-HSA-9010775]


organism-modification



PR:000062739

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed phosphorylated 2 (human)

hROBO3/iso:ROBO3A.1/SigPep-/Phos:2


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that has been phosphorylated on the residue at the position equivalent to Tyr-1019 of the amino acid sequence represented by UniProtKB:Q96MS0-1. UniProtKB:Q96MS0-1, 21-1386, Tyr-1019, MOD:00048." [PRO:DNx, Reactome:R-HSA-9011239]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


organism-modification



PR:000064762

roundabout homolog 3 isoform ROBO3A.1, signal peptide removed ubiquitinated form (human)

hROBO3/iso:ROBO3A.1/SigPep-/UbiqLys+


"A roundabout homolog 3 isoform ROBO3A.1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:Q96MS0-1, 21-1386, MOD:01148." [PRO:DNx, Reactome:R-HSA-9011301]


sequence



PR:000037774

roundabout homolog 3 isoform ROBO3B.1

ROBO3/iso:ROBO3B.1


"A roundabout homolog 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:E9QPQ1 or a 1:1 ortholog thereof. Isoforms ROBO3B have a shorter N-terminal sequence than isoforms ROBO3A. Isoforms ROBO3.1 have a C-terminal sequence highly enriched in arginine/serine dipeptide repeats." [PMID:18466743, PRO:CNA]


organism-sequence



PR:E9QPQ1

roundabout homolog 3 isoform ROBO3B.1 (mouse)

mROBO3/iso:B1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of mouse. This isoform has a shorter N-terminal sequence in comparison with ROBO3A isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats." [PMID:16554811, PMID:18466743, PRO:KRC]


organism-sequence



PR:F5GWJ5

roundabout homolog 3 isoform ROBO3B.1 (human)

hROBO3/iso:ROBO3B.1


"A roundabout homolog 3 isoform ROBO3B.1 that is encoded in the genome of human." [PMID:16554811, PMID:19690332, PRO:CNA, UniProtKB:F5GWJ5]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000037777 mROBO3/iso:ROBO3[A/B]1
The resulting 78 amino acid peptide is highly enriched in arginine/serine dipeptide repeats
acts_upstream_of_or_withinGO:0061642 chemoattraction of axon MGI_ref:3834283; PMID:18466743
located_inGO:0030424 axon MGI_ref:3834283; PMID:18466743
PR:000037778 mROBO3/iso:ROBO3[A/B]2 acts_upstream_of_or_withinGO:0061643 chemorepulsion of axon MGI_ref:3834283; PMID:18466743
located_inGO:0030424 axon MGI_ref:3834283; PMID:18466743
PR:D3Z4M6 mROBO3/iso:ROBO3A1
This isoform has a longer N-terminal sequence in comparison with ROBO3B isoforms and the C-terminal sequence arises from splicing of exon 26 to exon 27 and then to exon 28, with the resulting 78 amino acid peptide highly enriched in arginine/serine dipeptide repeats
acts_upstream_of_or_withinGO:0016199 axon midline choice point recognition MGI_ref:3834283; PMID:18466743
GO:0061642 chemoattraction of axon MGI_ref:3834283; PMID:18466743
GO:0071679 commissural neuron axon guidance MGI_ref:3834283; PMID:18466743