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Protein Ontology report - proto-oncogene tyrosine-protein kinase receptor Ret
PR:000013895 - http://purl.obolibrary.org/obo/PR_000013895
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000013895   
  PRO nameproto-oncogene tyrosine-protein kinase receptor Ret 
  Synonyms
PRO-Short-label: EXACT:RET
Gene-based: RELATED:CDHF12 | CDHR16 | PTC | RET51
Other: EXACT:cadherin family member 12 | proto-oncogene c-Ret
  Definition"A protein that is a translation product of the human RET gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2185
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000013895

proto-oncogene tyrosine-protein kinase receptor Ret

RET


"A protein that is a translation product of the human RET gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:G3V9H8

proto-oncogene tyrosine-protein kinase receptor Ret (rat)

rRET


"A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of rat." [OMA:G3V9H8, PRO:DNx]


organism-sequence



PR:G3V9H8-1

proto-oncogene tyrosine-protein kinase receptor Ret isoform r1 (rat)

rRET/iso:r1


"A proto-oncogene tyrosine-protein kinase receptor Ret (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G3V9H8-1." [PRO:DNx, UniProtKB:G3V9H8]


organism-sequence



PR:G3V9H8-2

proto-oncogene tyrosine-protein kinase receptor Ret isoform r2 (rat)

rRET/iso:r2


"A proto-oncogene tyrosine-protein kinase receptor Ret (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G3V9H8-2." [PRO:DNx, UniProtKB:G3V9H8]


organism-gene



PR:P07949

proto-oncogene tyrosine-protein kinase receptor Ret (human)

hRET


"A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human." [PRO:DNx, UniProtKB:P07949]


organism-sequence



PR:P07949-1

proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 (human)

hRET/iso:1


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07949]


organism-sequence



PR:P07949-2

proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 (human)

hRET/iso:2


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07949]


organism-modification



PR:000045653

proto-oncogene tyrosine-protein kinase receptor Ret phosphorylated 1 (human)

hRET/Phos:1


"A proto-oncogene tyrosine-protein kinase receptor Ret (human) that has been phosphorylated on the residue at the position equivalent to Thr-675 of the amino acid sequence represented by UniProtKB:P07949-1. Example: UniProtKB:P07949-1, Thr-675, MOD:00047." [iPTMnet:P07949, PMID:22128160]


organism-modification



PR:000049041

proto-oncogene tyrosine-protein kinase receptor Ret, signal peptide removed form (human)

hRET/SigPep-


"A proto-oncogene tyrosine-protein kinase receptor Ret (human) that has had the signal peptide removed. UniProtKB:P07949, 29-1114." [PRO:DNx, Reactome:R-HSA-8853797]


organism-modification



PR:000049042

proto-oncogene tyrosine-protein kinase receptor Ret, signal peptide removed phosphorylated 2 (human)

hRET/SigPep-/Phos:2


"A proto-oncogene tyrosine-protein kinase receptor Ret (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 905, 981, 1015, 1062 and 1096 of the amino acid sequence represented by UniProtKB:P07949. UniProtKB:P07949, 29-1114, Tyr-905/Tyr-981/Tyr-1015/Tyr-1062/Tyr-1096, MOD:00048." [PRO:DNx, Reactome:R-HSA-8854162]


organism-modification



PR:000073154

proto-oncogene tyrosine-protein kinase receptor Ret deaminated 1 (human)

hRET/Deam:1


"A proto-oncogene tyrosine-protein kinase receptor Ret (human) that has been deaminated on the residue at the position equivalent to Gln-497 of the amino acid sequence represented by UniProtKB:P07949-1. Example: UniProtKB:P07949-1, Gln-497, MOD:00685." [IEDB_epitope:2138679, PRO:DNx]


organism-gene



PR:P35546

proto-oncogene tyrosine-protein kinase receptor Ret (mouse)

mRET


"A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of mouse." [OMA:P35546, PRO:DNx]


organism-sequence



PR:P35546-1

proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 (mouse)

mRET/iso:1


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 that is encoded in the genome of mouse." [PMID:8455936, PRO:HJD]


organism-sequence



PR:P35546-2

proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 (mouse)

mRET/iso:2


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]

Yes

sequence



PR:000037459

proto-oncogene tyrosine-protein kinase receptor Ret isoform 1

RET/iso:1


"A proto-oncogene tyrosine-protein kinase receptor Ret that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35546-1 or a 1:1 ortholog thereof." [PMID:8455936, PRO:HJD]


organism-sequence



PR:P07949-1

proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 (human)

hRET/iso:1


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07949]


organism-sequence



PR:P35546-1

proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 (mouse)

mRET/iso:1


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 1 that is encoded in the genome of mouse." [PMID:8455936, PRO:HJD]


sequence



PR:000037460

proto-oncogene tyrosine-protein kinase receptor Ret isoform 2

RET/iso:2


"A proto-oncogene tyrosine-protein kinase receptor Ret that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35546-2 or a 1:1 ortholog thereof." [PMID:16141072, PRO:HJD]


organism-sequence



PR:P07949-2

proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 (human)

hRET/iso:2


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P07949]


organism-sequence



PR:P35546-2

proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 (mouse)

mRET/iso:2


"A proto-oncogene tyrosine-protein kinase receptor Ret isoform 2 that is encoded in the genome of mouse." [PMID:16141072, PRO:HJD]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P35546-2 mRET/iso:2 acts_upstream_of_or_withinGO:0001838 embryonic epithelial tube formation MGI_ref:3513229; PMID:15569713