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Protein Ontology report - transcription factor p65
PR:000013875 - http://purl.obolibrary.org/obo/PR_000013875
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000013875   
  PRO nametranscription factor p65 
  Synonyms
PRO-Short-label: EXACT:RELA
Gene-based: RELATED:NFKB3
Other: EXACT:nuclear factor NF-kappa-B p65 subunit | nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
  Definition"A protein that is a translation product of the human RELA gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 7                                        
         Modification2                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000013875
transcription factor p65
RELA
"A protein that is a translation product of the human RELA gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P98152
transcription factor p65 (chicken)
chick-RELA
"A transcription factor p65 that is encoded in the genome of chicken." [OMA:P98152, PRO:DNx]

organism-gene


PR:Q04206
transcription factor p65 (human)
hRELA
"A transcription factor p65 that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:Q04206-1
transcription factor p65 isoform 1 (human)
hRELA/iso:1
"A transcription factor p65 isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000027918
transcription factor p65 isoform 1 acetylated 1 (human)
hRELA/iso:1/Ac:1
"A transcription factor p65 isoform 1 acetylated 1 in human. UniProtKB:Q04206-1, Lys-310/Lys-314/Lys-315, MOD:00064." [KAT:Q04206, PMID:20064247]

organism-modification


PR:000027920
transcription factor p65 isoform 1 acetylated 2 (human)
hRELA/iso:1/Ac:2
"A transcription factor p65 isoform 1 acetylated 2 in human. UniProtKB:Q04206-1, Lys-122/Lys-123, MOD:00064." [KAT:Q04206, PMID:12419806]

organism-sequence


PR:Q04206-2
transcription factor p65 isoform h2 (human)
hRELA/iso:h2
"A transcription factor p65 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04206-2." [PRO:DNx, UniProtKB:Q04206]

organism-sequence


PR:Q04206-3
transcription factor p65 isoform h3 (human)
hRELA/iso:h3
"A transcription factor p65 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04206-3." [PRO:DNx, UniProtKB:Q04206]

organism-sequence


PR:Q04206-4
transcription factor p65 isoform h4 (human)
hRELA/iso:h4
"A transcription factor p65 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04206-4." [PRO:DNx, UniProtKB:Q04206]

organism-modification


PR:000045875
transcription factor p65 phosphorylated 1 (human)
hRELA/Phos:1
"A transcription factor p65 (human) that has been phosphorylated on the residue at the position equivalent to Ser-536 of the amino acid sequence represented by UniProtKB:Q04206-1. Example: UniProtKB:Q04206-1, Ser-536, MOD:00046." [iPTMnet:Q04206, PMID:15128824, PMID:15485852, PMID:15489227, PMID:16840782, PMID:17785205]

organism-modification


PR:000049038
transcription factor p65 phosphorylated 2 (human)
hRELA/Phos:2
"A transcription factor p65 (human) that has been phosphorylated on the residue at the position equivalent to Ser-276 of the amino acid sequence represented by UniProtKB:Q04206. UniProtKB:Q04206, Ser-276, MOD:00046." [PRO:DNx, Reactome:R-HSA-5624468]

organism-modification


PR:000061115
transcription factor p65 monomethylated 1 (human)
hRELA/Me1:1
"A transcription factor p65 (human) that has been monomethylated on the residue at the position equivalent to Lys-310 of the amino acid sequence represented by UniProtKB:Q04206-1. Example: UniProtKB:Q04206-1, Lys-310, MOD:00085." [PRO:DNx, Reactome:R-HSA-8865233]

organism-modification


PR:000061138
transcription factor p65 acetylated and phosphorylated 1 (human)
hRELA/AcPhos:1
"A transcription factor p65 (human) that has been acetylated on the residues at the positions equivalent to Lys-122, Lys-123, Lys-218, Lys-221 and Lys-310, and phosphorylated on the residue at the position equivalent to Ser-276 of the amino acid sequence represented by UniProtKB:Q04206-1. Example: UniProtKB:Q04206-1, Lys-122/Lys-123/Lys-218/Lys-221/Lys-310, MOD:00064|Ser-276, MOD:00046." [PRO:DNx, Reactome:R-HSA-5660642]

organism-modification


PR:000064756
transcription factor p65 sumoylated 1 (human)
hRELA/Sumo:1
"A transcription factor p65 (human) that has been sumoylated on the residues at the positions equivalent to Lys-37, Lys-122, and Lys-123 of the amino acid sequence represented by UniProtKB:Q04206-1. Example: UniProtKB:Q04206-1, Lys-37/Lys-122/Lys-123, MOD:01149." [PRO:DNx, Reactome:R-HSA-4755466]

organism-modification


PR:000081156
transcription factor p65 methylated 1 (human)
hRELA/Me:1
"A transcription factor p65 (human) that has been methylated on the residue at the position equivalent to Cys-160 of the amino acid sequence represented by UniProtKB:Q04206-1. Example: UniProtKB:Q04206-1, Cys-160, MOD:00660." [IEDB_epitope:1060827, PRO:DNx]

organism-gene


PR:Q04207
transcription factor p65 (mouse)
mRELA
"A transcription factor p65 that is encoded in the genome of mouse." [OMA:Q04207, PMID:2001591, PRO:CNA]

Yes
organism-sequence


PR:000050576
transcription factor p65 isoform m3 (mouse)
mRELA/iso:m3
"A transcription factor p65 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by GenPept:QOP57500." [PMID:34824310, PRO:HJD]

organism-sequence


PR:Q04207-1
transcription factor p65 isoform mp65 (mouse)
mRELA/iso:mp65
"A transcription factor p65 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04207-1." [PRO:DNx, UniProtKB:Q04207]

organism-sequence


PR:Q04207-2
transcription factor p65 isoform mp65 delta (mouse)
mRELA/iso:mp65 delta
"A transcription factor p65 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04207-2." [PRO:DNx, UniProtKB:Q04207]

organism-modification


PR:000045876
transcription factor p65 phosphorylated 1 (mouse)
mRELA/Phos:1
"A transcription factor p65 (mouse) that has been phosphorylated on the residue at the position equivalent to Ser-276 of the amino acid sequence represented by UniProtKB:Q04207-1. Example: UniProtKB:Q04207-1, Ser-276, MOD:00046." [iPTMnet:Q04207, PMID:15833743]

sequence


PR:000027915
transcription factor p65 isoform 1
RELA/iso:1
"A transcription factor p65 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04206-1 or a 1:1 ortholog thereof." [PMID:20064247]

organism-sequence


PR:Q04206-1
transcription factor p65 isoform 1 (human)
hRELA/iso:1
"A transcription factor p65 isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-modification


PR:000027918
transcription factor p65 isoform 1 acetylated 1 (human)
hRELA/iso:1/Ac:1
"A transcription factor p65 isoform 1 acetylated 1 in human. UniProtKB:Q04206-1, Lys-310/Lys-314/Lys-315, MOD:00064." [KAT:Q04206, PMID:20064247]

organism-modification


PR:000027920
transcription factor p65 isoform 1 acetylated 2 (human)
hRELA/iso:1/Ac:2
"A transcription factor p65 isoform 1 acetylated 2 in human. UniProtKB:Q04206-1, Lys-122/Lys-123, MOD:00064." [KAT:Q04206, PMID:12419806]

modification


PR:000027917
transcription factor p65 isoform 1 acetylated 1
RELA/iso:1/Ac:1
"A transcription factor p65 isoform 1 that has been acetylated in the Lys residues within the conserved sequence KSIMKK. Example: UniProtKB:Q04206-1, Lys-310/Lys-314/Lys-315, MOD:00064." [KAT:Q04206, PMID:20064247]

organism-modification


PR:000027918
transcription factor p65 isoform 1 acetylated 1 (human)
hRELA/iso:1/Ac:1
"A transcription factor p65 isoform 1 acetylated 1 in human. UniProtKB:Q04206-1, Lys-310/Lys-314/Lys-315, MOD:00064." [KAT:Q04206, PMID:20064247]

modification


PR:000027919
transcription factor p65 isoform 1 acetylated 2
RELA/iso:1/Ac:2
"A transcription factor p65 isoform 1 that has been acetylated in the Lys residues within the conserved sequence KKRDLE. Example: UniProtKB:Q04206-1, Lys-122/Lys-123, MOD:00064." [KAT:Q04206, PMID:12419806]

organism-modification


PR:000027920
transcription factor p65 isoform 1 acetylated 2 (human)
hRELA/iso:1/Ac:2
"A transcription factor p65 isoform 1 acetylated 2 in human. UniProtKB:Q04206-1, Lys-122/Lys-123, MOD:00064." [KAT:Q04206, PMID:12419806]

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RELA forms found in complexes   

RELA Component
 Complexes
PR:Q04206 hRELA PR:000035835 NF-kappaB p50/p65 complex (human)
PR:Q04207 mRELA PR:000028542 NF-kappaB p50/p65 complex (mouse)
PR:000036043 IRF3-P:p65 complex (mouse)
PR:000036047 IRF3-P:p65:ISRE complex (mouse)