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Protein Ontology report - presenilin-2
PR:000013345 - http://purl.obolibrary.org/obo/PR_000013345
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000013345   
  PRO namepresenilin-2 
  Synonyms
PRO-Short-label: EXACT:PSEN2
Gene-based: RELATED:AD4 | Ad4h | Alg3 | PS2 | PSNL2 | STM2
Other: EXACT:AD3LP | AD5 | E5-1 | PS-2 | STM-2
  Definition"A protein that is a translation product of the human PSEN2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  CommentRequested by=Alzforum. 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence3                                                  Organism-Sequence 56                                        
         Modification4                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2403
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000013345

presenilin-2

PSEN2


"A protein that is a translation product of the human PSEN2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O02194

presenilin homolog (fruit fly)

fly-PSEN2


"A presenilin-2 that is encoded in the genome of fruit fly." [OMA:O02194, PRO:DNx]


organism-sequence



PR:O02194-1

presenilin homolog isoform 1 (fruit fly)

fly-PSEN2/iso:1


"A presenilin homolog (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O02194-1." [PRO:DNx, UniProtKB:O02194]


organism-sequence



PR:O02194-2

presenilin homolog isoform 2 (fruit fly)

fly-PSEN2/iso:2


"A presenilin homolog (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O02194-2." [PRO:DNx, UniProtKB:O02194]


organism-sequence



PR:O02194-3

presenilin homolog isoform 3 (fruit fly)

fly-PSEN2/iso:3


"A presenilin homolog (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O02194-3." [PRO:DNx, UniProtKB:O02194]


organism-gene



PR:O88777

presenilin-2 (rat)

rPSEN2


"A presenilin-2 that is encoded in the genome of rat." [OMA:O88777, PRO:DNx]


organism-gene



PR:P49810

presenilin-2 (human)

hPSEN2


"A presenilin-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49810]


organism-sequence



PR:000036286

presenilin-2 sequence variant (human)

hPSEN2/var+


"A presenilin-2 (human) that has at least one amino acid residue that differs from the corresponding residue found in another presenilin-2 (human) when such a difference arises as the result of genetic differences, i.e., different alleles of presenilin-2 (human). Operationally, this means the sequence representation of the presenilin-2 (human) has at least one amino acid residue that differs from the corresponding residue found in the sequence represened by UniProtKB:P49810-1." [PRO:DAN]


organism-sequence



PR:000037741

presenilin-2 sequence variant R29H (human)

hPSEN2/var:R29H


"A presenilin-2 sequence variant (human) that has a His residue at the position equivalent to Arg-29 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Arg-29, CHEBI:29979." [Alzforum:KD, PMID:18667258, PRO:DAN]


organism-sequence



PR:000037742

presenilin-2 sequence variant G34S (human)

hPSEN2/var:G34S


"A presenilin-2 sequence variant (human) that has a Ser residue at the position equivalent to Gly-34 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Gly-34, CHEBI:29999." [Alzforum:KD, PMID:15130954, PRO:DAN]


organism-sequence



PR:000037743

presenilin-2 sequence variant R62H (human)

hPSEN2/var:R62H


"A presenilin-2 sequence variant (human) that has a His residue at the position equivalent to Arg-62 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Arg-62, CHEBI:29979." [Alzforum:KD, PMID:19768372, PMID:9384602, PRO:DAN]


organism-sequence



PR:000037744

presenilin-2 sequence variant R62C (human)

hPSEN2/var:R62C


"A presenilin-2 sequence variant (human) that has a Cys residue at the position equivalent to Arg-62 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Arg-62, CHEBI:29950." [Alzforum:KD, PMID:15130954, PMID:17914065, PMID:18608129, PRO:DAN]


organism-sequence



PR:000037745

presenilin-2 sequence variant P69A (human)

hPSEN2/var:P69A


"A presenilin-2 sequence variant (human) that has an Ala residue at the position equivalent to Pro-69 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Pro-69, CHEBI:46217." [Alzforum:KD, PMID:22221884, PRO:DAN]


organism-sequence



PR:000037746

presenilin-2 sequence variant R71W (human)

hPSEN2/var:R71W


"A presenilin-2 sequence variant (human) that has a Trp residue at the position equivalent to Arg-71 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Arg-71, CHEBI:29954." [Alzforum:KD, PMID:15130954, PRO:DAN]


organism-sequence



PR:000037747

presenilin-2 sequence variant A85V (human)

hPSEN2/var:A85V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Ala-85 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-85, CHEBI:30015." [Alzforum:KD, PMID:18427071, PRO:DAN]

Yes

organism-sequence



PR:000037748

presenilin-2 sequence variant T122P (human)

hPSEN2/var:T122P


"A presenilin-2 sequence variant (human) that has a Pro residue at the position equivalent to Thr-122 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Thr-122, CHEBI:50342." [Alzforum:KD, PMID:10631141, PRO:DAN]

Yes

organism-sequence



PR:000037749

presenilin-2 sequence variant T122R (human)

hPSEN2/var:T122R


"A presenilin-2 sequence variant (human) that has an Arg residue at the position equivalent to Thr-122 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Thr-122, CHEBI:29952." [Alzforum:KD, PMID:14681895, PRO:DAN]


organism-sequence



PR:000037750

presenilin-2 sequence variant E126K (human)

hPSEN2/var:E126K


"A presenilin-2 sequence variant (human) that has a Lys residue at the position equivalent to Glu-126 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Glu-126, CHEBI:29967." [Alzforum:KD, PMID:24844686, PRO:DAN]

Yes

organism-sequence



PR:000037751

presenilin-2 sequence variant S130L (human)

hPSEN2/var:S130L


"A presenilin-2 sequence variant (human) that has a Leu residue at the position equivalent to Ser-130 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ser-130, CHEBI:30006." [Alzforum:KD, PMID:14623725, PRO:DAN]


organism-sequence



PR:000037752

presenilin-2 sequence variant V139M (human)

hPSEN2/var:V139M


"A presenilin-2 sequence variant (human) that has a Met residue at the position equivalent to Val-139 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Val-139, CHEBI:16044." [Alzforum:KD, PMID:18350357, PRO:DAN]


organism-sequence



PR:000037753

presenilin-2 sequence variant N141I (human)

hPSEN2/var:N141I


"A presenilin-2 sequence variant (human) that has an Ile residue at the position equivalent to Asn-141 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Asn-141, CHEBI:30009." [Alzforum:KD, PMID:7638622, PMID:7651536, PRO:DAN]

Yes

organism-sequence



PR:000037754

presenilin-2 sequence variant N141Y (human)

hPSEN2/var:N141Y


"A presenilin-2 sequence variant (human) that has a Tyr residue at the position equivalent to Asn-141 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Asn-141, CHEBI:46858." [Alzforum:KD, PMID:24838186, PRO:DAN]

Yes

organism-sequence



PR:000037755

presenilin-2 sequence variant L143H (human)

hPSEN2/var:L143H


"A presenilin-2 sequence variant (human) that has a His residue at the position equivalent to Leu-143 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Leu-143, CHEBI:29979." [Alzforum:KD, PMID:18667258, PRO:DAN]


organism-sequence



PR:000037756

presenilin-2 sequence variant V148I (human)

hPSEN2/var:V148I


"A presenilin-2 sequence variant (human) that has an Ile residue at the position equivalent to Val-148 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Val-148, CHEBI:30009." [Alzforum:KD, PMID:10732806, PRO:DAN]

Yes

organism-sequence



PR:000037757

presenilin-2 sequence variant R163H (human)

hPSEN2/var:R163H


"A presenilin-2 sequence variant (human) that has a His residue at the position equivalent to Arg-163 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Arg-163, CHEBI:29979." [Alzforum:KD, PMID:19632874, PRO:DAN]


organism-sequence



PR:000037758

presenilin-2 sequence variant M174V (human)

hPSEN2/var:M174V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Met-174 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Met-174, CHEBI:30015." [Alzforum:KD, PMID:18667258, PMID:18846634, PRO:DAN]


organism-sequence



PR:000037759

presenilin-2 sequence variant S175C (human)

hPSEN2/var:S175C


"A presenilin-2 sequence variant (human) that has a Cys residue at the position equivalent to Ser-175 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ser-175, CHEBI:29950." [Alzforum:KD, PMID:20164579, PRO:DAN]

Yes

organism-sequence



PR:000037760

presenilin-2 sequence variant V214L (human)

hPSEN2/var:V214L


"A presenilin-2 sequence variant (human) that has a Leu residue at the position equivalent to Val-214 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Val-214, CHEBI:30006." [Alzforum:KD, PMID:24885952, PRO:DAN]

Yes

organism-sequence



PR:000037761

presenilin-2 sequence variant Q228L (human)

hPSEN2/var:Q228L


"A presenilin-2 sequence variant (human) that has a Leu residue at the position equivalent to Gln-228 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Gln-228, CHEBI:30006." [Alzforum:KD, PMID:14769392, PRO:DAN]

Yes

organism-sequence



PR:000037762

presenilin-2 sequence variant Y231C (human)

hPSEN2/var:Y231C


"A presenilin-2 sequence variant (human) that has a Cys residue at the position equivalent to Tyr-231 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Tyr-231, CHEBI:29950." [Alzforum:KD, PMID:19276543, PRO:DAN]


organism-sequence



PR:000037763

presenilin-2 sequence variant M239V (human)

hPSEN2/var:M239V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Met-239 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Met-239, CHEBI:30015." [Alzforum:KD, PMID:7651536, PRO:DAN]

Yes

organism-sequence



PR:000037764

presenilin-2 sequence variant M239I (human)

hPSEN2/var:M239I


"A presenilin-2 sequence variant (human) that has an Ile residue at the position equivalent to Met-239 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Met-239, CHEBI:30009." [Alzforum:KD, PMID:10822446, PRO:DAN]

Yes

organism-sequence



PR:000037765

presenilin-2 sequence variant A252T (human)

hPSEN2/var:A252T


"A presenilin-2 sequence variant (human) that has a Thr residue at the position equivalent to Ala-252 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-252, CHEBI:30013." [Alzforum:KD, PMID:18667258, PRO:DAN]


organism-sequence



PR:000037766

presenilin-2 sequence variant P334R (human)

hPSEN2/var:P334R


"A presenilin-2 sequence variant (human) that has an Arg residue at the position equivalent to Pro-334 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Pro-334, CHEBI:29952." [Alzforum:KD, PMID:11803125, PRO:DAN]


organism-sequence



PR:000037767

presenilin-2 sequence variant V393M (human)

hPSEN2/var:V393M


"A presenilin-2 sequence variant (human) that has a Met residue at the position equivalent to Val-393 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Val-393, CHEBI:16044." [Alzforum:KD, PMID:18727676, PRO:DAN]


organism-sequence



PR:000037768

presenilin-2 sequence variant T430M (human)

hPSEN2/var:T430M


"A presenilin-2 sequence variant (human) that has a Met residue at the position equivalent to Thr-430 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Thr-430, CHEBI:16044." [Alzforum:KD, PMID:12925374, PRO:DAN]

Yes

organism-sequence



PR:000037769

presenilin-2 sequence variant D439A (human)

hPSEN2/var:D439A


"A presenilin-2 sequence variant (human) that has an Ala residue at the position equivalent to Asp-439 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Asp-439, CHEBI:46217." [Alzforum:KD, PMID:11723295, PRO:DAN]


organism-sequence



PR:000044560

presenilin-2 sequence variant G212V (human)

hPSEN2/var:G212V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Gly-212 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Gly-212, CHEBI:30015." [Alzforum:KD, PRO:DAN]

Yes

organism-sequence



PR:000044561

presenilin-2 sequence variant L238P (human)

hPSEN2/var:L238P


"A presenilin-2 sequence variant (human) that has a Pro residue at the position equivalent to Leu-238 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Leu-238, CHEBI:50342." [Alzforum:KD, PRO:DAN]

Yes

organism-sequence



PR:000044562

presenilin-2 sequence variant P348L (human)

hPSEN2/var:P348L


"A presenilin-2 sequence variant (human) that has a Leu residue at the position equivalent to Pro-348 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Pro-348, CHEBI:30006." [Alzforum:KD, PRO:DAN]


organism-sequence



PR:000044563

presenilin-2 sequence variant T18M (human)

hPSEN2/var:T18M


"A presenilin-2 sequence variant (human) that has a Met residue at the position equivalent to Thr-18 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Thr-18, CHEBI:16044." [Alzforum:KD, PRO:DAN]


organism-sequence



PR:000045476

presenilin-2 sequence variant K82R (human)

hPSEN2/var:K82R


"A presenilin-2 sequence variant (human) that has an Arg residue at the position equivalent to Lys-82 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Lys-82, CHEBI:29952." [Alzforum:KD, PMID:25323700, PRO:DAN]


organism-sequence



PR:000045477

presenilin-2 sequence variant V101M (human)

hPSEN2/var:V101M


"A presenilin-2 sequence variant (human) that has a Met residue at the position equivalent to Val-101 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Val-101, CHEBI:16044." [Alzforum:KD, PMID:25937274, PRO:DAN]


organism-sequence



PR:000045478

presenilin-2 sequence variant P123L (human)

hPSEN2/var:P123L


"A presenilin-2 sequence variant (human) that has a Leu residue at the position equivalent to Pro-123 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Pro-123, CHEBI:30006." [Alzforum:KD, PMID:26422362, PRO:DAN]


organism-sequence



PR:000045479

presenilin-2 sequence variant K161R (human)

hPSEN2/var:K161R


"A presenilin-2 sequence variant (human) that has an Arg residue at the position equivalent to Lys-161 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Lys-161, CHEBI:29952." [Alzforum:KD, PMID:22475797, PRO:DAN]

Yes

organism-sequence



PR:000045480

presenilin-2 sequence variant H169N (human)

hPSEN2/var:H169N


"A presenilin-2 sequence variant (human) that has an Asn residue at the position equivalent to His-169 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, His-169, CHEBI:50347." [Alzforum:KD, PMID:25323700, PRO:DAN]


organism-sequence



PR:000045481

presenilin-2 sequence variant I235F (human)

hPSEN2/var:I235F


"A presenilin-2 sequence variant (human) that has a Phe residue at the position equivalent to Ile-235 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ile-235, CHEBI:29997." [Alzforum:KD, PMID:25333068, PRO:DAN]


organism-sequence



PR:000045482

presenilin-2 sequence variant A237V (human)

hPSEN2/var:A237V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Ala-237 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-237, CHEBI:30015." [Alzforum:KD, PMID:25104557, PRO:DAN]


organism-sequence



PR:000045483

presenilin-2 sequence variant L238F (human)

hPSEN2/var:L238F


"A presenilin-2 sequence variant (human) that has a Phe residue at the position equivalent to Leu-238 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Leu-238, CHEBI:29997." [Alzforum:KD, PMID:25937274, PRO:DAN]


organism-sequence



PR:000045484

presenilin-2 sequence variant A258T (human)

hPSEN2/var:A258T


"A presenilin-2 sequence variant (human) that has a Thr residue at the position equivalent to Ala-258 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-258, CHEBI:30013." [Alzforum:KD, PMID:25937274, PRO:DAN]


organism-sequence



PR:000045485

presenilin-2 sequence variant T301M (human)

hPSEN2/var:T301M


"A presenilin-2 sequence variant (human) that has a Met residue at the position equivalent to Thr-301 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Thr-301, CHEBI:16044." [Alzforum:KD, PMID:15258222, PRO:DAN]


organism-sequence



PR:000045486

presenilin-2 sequence variant P334A (human)

hPSEN2/var:P334A


"A presenilin-2 sequence variant (human) that has an Ala residue at the position equivalent to Pro-334 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Pro-334, CHEBI:46217." [Alzforum:KD, PMID:25333068, PRO:DAN]


organism-sequence



PR:000045487

presenilin-2 sequence variant A377V (human)

hPSEN2/var:A377V


"A presenilin-2 sequence variant (human) that has a Val residue at the position equivalent to Ala-377 of the amino acid sequence represented by UniProtKB:P49810-1. Example: UniProtKB:P49810-1, Ala-377, CHEBI:30015." [Alzforum:KD, PMID:25333068, PRO:DAN]


organism-sequence



PR:000036856

presenilin-2 isoform PS2beta (human)

hPSEN2/iso:PS2beta


"A presenilin-2 isoform PS2beta that is encoded in the genome of human." [PMID:19376115, PRO:CNA]


organism-sequence



PR:P49810-1

presenilin-2 isoform 1 (human)

hPSEN2/iso:1


"A presenilin-2 isoform 1 that is encoded in the genome of human." [PMID:19376115, PRO:CNA]


organism-sequence



PR:P49810-2

presenilin-2 isoform h2 (human)

hPSEN2/iso:h2


"A presenilin-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49810-2." [PRO:DNx, UniProtKB:P49810]


organism-sequence



PR:P49810-3

presenilin-2 isoform h3 (human)

hPSEN2/iso:h3


"A presenilin-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49810-3." [PRO:DNx, UniProtKB:P49810]


organism-gene



PR:P52166

presenilin sel-12 (worm)

PSEN2 (worm)


"A presenilin-2 that is encoded in the genome of worm." [OMA:P52166, PRO:DNx]


organism-gene



PR:Q61144

presenilin-2 (mouse)

mPSEN2


"A presenilin-2 that is encoded in the genome of mouse." [OMA:Q61144, PRO:CNA]


organism-sequence



PR:000036858

presenilin-2 isoform PS2short (mouse)

mPSEN2/iso:PS2short


"A presenilin-2 isoform PS2short that is encoded in the genome of mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:KRC]

Yes

union



PR:000036891

PS2s (mouse)

mPS2s


"A presenilin-2 (mouse) that results from either translation of an alternative short PS2 transcript or by proteolysis of PS2 isoform 1. Example: UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:KRC]


organism-sequence



PR:000036858

presenilin-2 isoform PS2short (mouse)

mPSEN2/iso:PS2short


"A presenilin-2 isoform PS2short that is encoded in the genome of mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:KRC]


organism-modification



PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)

mPSEN2/iso:1/Clv:CTF


"A presenilin-2 isoform 1 CTF subunit in mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]


organism-sequence



PR:Q61144-1

presenilin-2 isoform 1 (mouse)

mPSEN2/iso:1


"A presenilin-2 isoform 1 that is encoded in the genome of mouse." [PMID:19376115, PRO:KRC]


organism-modification



PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Cter


"A presenilin-2 isoform 1 C-terminal fragment in mouse. UniProtKB:Q61144-1, 330-448." [PMID:9353287, PRO:KRC]


organism-modification



PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Nter


"A presenilin-2 isoform 1 N-terminal fragment in mouse. UniProtKB:Q61144-1, 1-329." [PMID:9353287, PRO:KRC]


organism-modification



PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)

mPSEN2/iso:1/Clv:CTF


"A presenilin-2 isoform 1 CTF subunit in mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]


organism-sequence



PR:Q61144-2

presenilin-2 isoform PS2beta (mouse)

mPSEN2/iso:PS2beta


"A presenilin-2 isoform PS2beta that is encoded in the genome of mouse. The sequence is shorter (361 residues long) than isoform 1 sharing the same sequence up to residue 357, followed by the sequence SKGA." [PMID:19376115, PRO:KRC]

Yes

organism-gene



PR:Q90ZE4

presenilin-2 (zebrafish)

z-PSEN2


"A presenilin-2 that is encoded in the genome of zebrafish." [OMA:Q90ZE4, PRO:DNx]


sequence



PR:000036851

presenilin-2 isoform 1

PSEN2/iso:1


"A presenilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61144-1 or a 1:1 ortholog thereof." [PMID:19376115, PRO:CNA]


organism-sequence



PR:P49810-1

presenilin-2 isoform 1 (human)

hPSEN2/iso:1


"A presenilin-2 isoform 1 that is encoded in the genome of human." [PMID:19376115, PRO:CNA]


organism-sequence



PR:Q61144-1

presenilin-2 isoform 1 (mouse)

mPSEN2/iso:1


"A presenilin-2 isoform 1 that is encoded in the genome of mouse." [PMID:19376115, PRO:KRC]


organism-modification



PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Cter


"A presenilin-2 isoform 1 C-terminal fragment in mouse. UniProtKB:Q61144-1, 330-448." [PMID:9353287, PRO:KRC]


organism-modification



PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Nter


"A presenilin-2 isoform 1 N-terminal fragment in mouse. UniProtKB:Q61144-1, 1-329." [PMID:9353287, PRO:KRC]


organism-modification



PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)

mPSEN2/iso:1/Clv:CTF


"A presenilin-2 isoform 1 CTF subunit in mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]


modification



PR:000036881

presenilin-2 isoform 1 C-terminal fragment

PSEN2/iso:1/Clv:Cter


"A presenilin-2 isoform 1 that has been cleaved at the caspase-3 consensus site DSYD to yield the C-terminal region. Example: UniProtKB:Q61144-1, 330-448." [PMID:9353287, PRO:CNA]


organism-modification



PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Cter


"A presenilin-2 isoform 1 C-terminal fragment in mouse. UniProtKB:Q61144-1, 330-448." [PMID:9353287, PRO:KRC]


modification



PR:000036887

presenilin-2 isoform 1 N-terminal fragment

PSEN2/iso:1/Clv:Nter


"A presenilin-2 isoform 1 that has been cleaved at the caspase-3 consensus site DSYD to yield the N-terminal region. Example: UniProtKB:Q61144-1, 1-329." [PMID:9353287, PRO:CNA]


organism-modification



PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Nter


"A presenilin-2 isoform 1 N-terminal fragment in mouse. UniProtKB:Q61144-1, 1-329." [PMID:9353287, PRO:KRC]


modification



PR:000036889

presenilin-2 isoform 1 CTF subunit

PSEN2/iso:1/Clv:CTF


"A presenilin-2 isoform 1 that has been proteolytically cleaved to yield the C-terminal region analogous to the amino acid region 298-448 in mouse sequence. Example: UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]


organism-modification



PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)

mPSEN2/iso:1/Clv:CTF


"A presenilin-2 isoform 1 CTF subunit in mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]


sequence



PR:000036853

presenilin-2 isoform PS2beta

PSEN2/iso:PS2beta


"A presenilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61144-2 or a 1:1 ortholog thereof. This isoform contains N-terminal fragment (NTF) and hydrophilic loop domain, but not C-terminal fragment (CTF)." [PMID:19376115, PRO:CNA]


organism-sequence



PR:000036856

presenilin-2 isoform PS2beta (human)

hPSEN2/iso:PS2beta


"A presenilin-2 isoform PS2beta that is encoded in the genome of human." [PMID:19376115, PRO:CNA]


organism-sequence



PR:Q61144-2

presenilin-2 isoform PS2beta (mouse)

mPSEN2/iso:PS2beta


"A presenilin-2 isoform PS2beta that is encoded in the genome of mouse. The sequence is shorter (361 residues long) than isoform 1 sharing the same sequence up to residue 357, followed by the sequence SKGA." [PMID:19376115, PRO:KRC]

Yes

sequence



PR:000036857

presenilin-2 isoform PS2short

PSEN2/iso:PS2short


"A presenilin-2 that is a translation product of some mRNA produced by alternative promoter usage, giving rise to a protein with the amino acid sequence represented by residues 298 to 448 in UniProtKB:Q61144 or a 1:1 ortholog thereof." [PMID:9353287, PRO:CNA]


organism-sequence



PR:000036858

presenilin-2 isoform PS2short (mouse)

mPSEN2/iso:PS2short


"A presenilin-2 isoform PS2short that is encoded in the genome of mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:KRC]

Yes

modification



PR:000036880

presenilin-2 proteolytic cleavage product

PSEN2/ClvPrd


"A presenilin-2 that has been processed by proteolytic cleavage." [PRO:CNA, PRO:DAN]


modification



PR:000036881

presenilin-2 isoform 1 C-terminal fragment

PSEN2/iso:1/Clv:Cter


"A presenilin-2 isoform 1 that has been cleaved at the caspase-3 consensus site DSYD to yield the C-terminal region. Example: UniProtKB:Q61144-1, 330-448." [PMID:9353287, PRO:CNA]


organism-modification



PR:000036886

presenilin-2 isoform 1 C-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Cter


"A presenilin-2 isoform 1 C-terminal fragment in mouse. UniProtKB:Q61144-1, 330-448." [PMID:9353287, PRO:KRC]


modification



PR:000036887

presenilin-2 isoform 1 N-terminal fragment

PSEN2/iso:1/Clv:Nter


"A presenilin-2 isoform 1 that has been cleaved at the caspase-3 consensus site DSYD to yield the N-terminal region. Example: UniProtKB:Q61144-1, 1-329." [PMID:9353287, PRO:CNA]


organism-modification



PR:000036888

presenilin-2 isoform 1 N-terminal fragment (mouse)

mPSEN2/iso:1/Clv:Nter


"A presenilin-2 isoform 1 N-terminal fragment in mouse. UniProtKB:Q61144-1, 1-329." [PMID:9353287, PRO:KRC]


modification



PR:000036889

presenilin-2 isoform 1 CTF subunit

PSEN2/iso:1/Clv:CTF


"A presenilin-2 isoform 1 that has been proteolytically cleaved to yield the C-terminal region analogous to the amino acid region 298-448 in mouse sequence. Example: UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]


organism-modification



PR:000036890

presenilin-2 isoform 1 CTF subunit (mouse)

mPSEN2/iso:1/Clv:CTF


"A presenilin-2 isoform 1 CTF subunit in mouse. UniProtKB:Q61144-1, 298-448." [PMID:9353287, PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036858 mPSEN2/iso:PS2short
UniProtKB:Q61144-1, 298-448
acts_upstream_of_or_withinGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors MGI_ref:1099227; PMID:9353287
PR:000037747 hPSEN2/var:A85V
Example: UniProtKB:P49810-1, Ala-85, CHEBI:30015
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-a85v
PR:000037748 hPSEN2/var:T122P
Example: UniProtKB:P49810-1, Thr-122, CHEBI:50342
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-t122p
PR:000037750 hPSEN2/var:E126K
Example: UniProtKB:P49810-1, Glu-126, CHEBI:29967
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-e126k
PR:000037753 hPSEN2/var:N141I
Example: UniProtKB:P49810-1, Asn-141, CHEBI:30009
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-n141i-volga-german
PR:000037754 hPSEN2/var:N141Y
Example: UniProtKB:P49810-1, Asn-141, CHEBI:46858
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-n141y
PR:000037756 hPSEN2/var:V148I
Example: UniProtKB:P49810-1, Val-148, CHEBI:30009
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-v148i
PR:000037759 hPSEN2/var:S175C
Example: UniProtKB:P49810-1, Ser-175, CHEBI:29950
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-s175c
PR:000037760 hPSEN2/var:V214L
Example: UniProtKB:P49810-1, Val-214, CHEBI:30006
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-v214l
PR:000037761 hPSEN2/var:Q228L
Example: UniProtKB:P49810-1, Gln-228, CHEBI:30006
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-q228l
PR:000037763 hPSEN2/var:M239V
Example: UniProtKB:P49810-1, Met-239, CHEBI:30015
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-m239v
PR:000037764 hPSEN2/var:M239I
Example: UniProtKB:P49810-1, Met-239, CHEBI:30009
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-m239i
PR:000037768 hPSEN2/var:T430M
Example: UniProtKB:P49810-1, Thr-430, CHEBI:16044
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-t430m
PR:000044560 hPSEN2/var:G212V
Example: UniProtKB:P49810-1, Gly-212, CHEBI:30015
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-g212v
PR:000044561 hPSEN2/var:L238P
Example: UniProtKB:P49810-1, Leu-238, CHEBI:50342
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-l238p
PR:000045479 hPSEN2/var:K161R
Example: UniProtKB:P49810-1, Lys-161, CHEBI:29952
associated_with_disease_progressionDO:10652 Alzheimer's disease Alzforum:psen2-k161r
PR:Q61144-2 mPSEN2/iso:PS2beta
The sequence is shorter (361 residues long) than isoform 1 sharing the same sequence up to residue 357, followed by the sequence SKGA
acts_upstream_of_or_withinGO:0031333 negative regulation of protein-containing complex assembly MGI_ref:3843380; PMID:19376115
GO:0032091 negative regulation of protein binding MGI_ref:3843380; PMID:19376115
located_inGO:0005783 endoplasmic reticulum MGI_ref:3843380; PMID:19376115