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Protein Ontology report - DNA polymerase beta
PR:000012962 - http://purl.obolibrary.org/obo/PR_000012962
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000012962   
  PRO nameDNA polymerase beta 
  Synonyms
PRO-Short-label: EXACT:POLB
Other: EXACT:5'-deoxyribose-phosphate lyase | 5'-dRP lyase | AP lyase
  Definition"A protein that is a translation product of the human POLB gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 1                                        
         Modification1                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000012962

DNA polymerase beta

POLB


"A protein that is a translation product of the human POLB gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P06746

DNA polymerase beta (human)

hPOLB


"A DNA polymerase beta that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P06746-1

DNA polymerase beta isoform 1 (human)

hPOLB/iso:1


"A DNA polymerase beta isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028604

DNA polymerase beta acetylated 1 (human)

hPOLB/Ac:1


"A DNA polymerase beta acetylated 1 in human. UniProtKB:P06746, Lys-72, MOD:00064." [KAT:P06746, PMID:12453427, PRO:PD]

Yes

organism-modification



PR:000045373

DNA polymerase beta unacetylated 1 (human)

hPOLB/UnAc:1


"A DNA polymerase beta (human) that lacks acetylation on the residue equivalent to Lys-72 of the amino acid sequence represented by UniProtKB:P06746. UniProtKB:P06746, Lys-72, PR:000026291." [PMID:12453427, PRO:CNA]

Yes

organism-modification



PR:000048840

DNA polymerase beta, initiator methionine removed ubiquitinated form (human)

hPOLB/InitMet-/UbiqLys+


"A DNA polymerase beta (human) that has had the initiator methionine removed and that includes at least one ubiquitinated lysine. UniProtKB:P06746, 2-335, MOD:01148." [PRO:DNx, Reactome:R-HSA-6783152]


organism-gene



PR:P06766

DNA polymerase beta (rat)

rPOLB


"A DNA polymerase beta that is encoded in the genome of rat." [OMA:P06766, PRO:DNx]


organism-gene



PR:Q6DRD3

DNA polymerase beta (zebrafish)

z-POLB


"A DNA polymerase beta that is encoded in the genome of zebrafish." [OMA:Q6DRD3, PRO:DNx]


organism-gene



PR:Q8K409

DNA polymerase beta (mouse)

mPOLB


"A DNA polymerase beta that is encoded in the genome of mouse." [OMA:Q8K409, PRO:DNx]


organism-gene



PR:Q9FNY4

DNA polymerase lambda (Arabidopsis thaliana)

At-POLB


"A DNA polymerase beta that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9FNY4, PRO:DNx]


sequence



PR:000028601

DNA polymerase beta isoform 1

POLB/iso:1


"A DNA polymerase beta that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P06746-1 or a 1:1 ortholog thereof." [PMID:12453427, PRO:PD]


organism-sequence



PR:P06746-1

DNA polymerase beta isoform 1 (human)

hPOLB/iso:1


"A DNA polymerase beta isoform 1 that is encoded in the genome of human." [PRO:PD]


modification



PR:000028603

DNA polymerase beta acetylated 1

POLB/Ac:1


"A DNA polymerase beta that is acetylated on the active site Lys residue. Example: UniProtKB:P06746, Lys-72, MOD:00064." [KAT:P06746, PMID:12453427, PRO:PD]


organism-modification



PR:000028604

DNA polymerase beta acetylated 1 (human)

hPOLB/Ac:1


"A DNA polymerase beta acetylated 1 in human. UniProtKB:P06746, Lys-72, MOD:00064." [KAT:P06746, PMID:12453427, PRO:PD]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000028604 hPOLB/Ac:1
UniProtKB:P06746, Lys-72, MOD:00064
enablesdecreased GO:0016829 lyase activity relative to PR:000045373 DNA polymerase beta unmodified form (human) PMID:12453427
PR:000045373 hPOLB/UnAc:1
UniProtKB:P06746, Lys-72, PR:000026291
acts_upstream_of_or_withinGO:0006284 base-excision repair PMID:12453427
enablesGO:0016829 lyase activity PMID:12453427