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Protein Ontology report - serine/threonine-protein kinase PLK1
PR:000012870 - http://purl.obolibrary.org/obo/PR_000012870
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000012870   
  PRO nameserine/threonine-protein kinase PLK1 
  Synonyms
PRO-Short-label: EXACT:PLK1
Gene-based: RELATED:PLK
Other: EXACT:PLK-1 | Polo-like kinase 1 | STPK13
RELATED:serine/threonine-protein kinase 13
  Definition"A protein that is a translation product of the human PLK1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2168
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000012870 serine/threonine-protein kinase PLK1
PLK1

organism-gene


PR:P52304 serine/threonine-protein kinase polo (fruit fly)
fly-PLK1

organism-gene


PR:P53350 serine/threonine-protein kinase PLK1 (human)
hPLK1
Yes
Yes
organism-sequence


PR:P53350-1 serine/threonine-protein kinase PLK1 isoform 1 (human)
hPLK1/iso:1

organism-modification


PR:000035669 serine/threonine-protein kinase PLK1 unphosphorylated form (human)
hPLK1/PhosRes-

organism-modification


PR:000044818 serine/threonine-protein kinase PLK1 phosphorylated 1 (human)
hPLK1/Phos:1
Yes
organism-modification


PR:000045826 serine/threonine-protein kinase PLK1 phosphorylated 2 (human)
hPLK1/Phos:2

organism-modification


PR:000048813 serine/threonine-protein kinase PLK1 phosphorylated 3 (human)
hPLK1/Phos:3

organism-modification


PR:000068734 serine/threonine-protein kinase PLK1 methylated 1 (human)
hPLK1/Me:1

organism-modification


PR:000075930 serine/threonine-protein kinase PLK1 deaminated 1 (human)
hPLK1/Deam:1

organism-modification


PR:000076381 serine/threonine-protein kinase PLK1 methylated 2 (human)
hPLK1/Me:2

organism-modification


PR:000083595 serine/threonine-protein kinase PLK1 cysteinylated 1 (human)
hPLK1/Cyst:1

organism-gene


PR:Q07832 serine/threonine-protein kinase PLK1 (mouse)
mPLK1

organism-sequence


PR:Q07832-1 serine/threonine-protein kinase PLK1 isoform 1 (mouse)
mPLK1/iso:1

organism-gene


PR:Q62673 serine/threonine-protein kinase PLK1 (rat)
rPLK1

sequence


PR:000039726 serine/threonine-protein kinase PLK1 isoform 1
PLK1/iso:1

organism-sequence


PR:P53350-1 serine/threonine-protein kinase PLK1 isoform 1 (human)
hPLK1/iso:1

organism-sequence


PR:Q07832-1 serine/threonine-protein kinase PLK1 isoform 1 (mouse)
mPLK1/iso:1

modification


PR:000035668 serine/threonine-protein kinase PLK1 unphosphorylated form
PLK1/PhosRes-

organism-modification


PR:000035669 serine/threonine-protein kinase PLK1 unphosphorylated form (human)
hPLK1/PhosRes-

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PLK1 forms found in complexes   

PLK1 Component
 Complexes
PR:P53350 hPLK1 PR:000035581 phosphoBUB1:PLK1 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000044818 hPLK1/Phos:1
UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047		 acts_upstream_of_or_withinGO:0007091 metaphase/anaphase transition of mitotic cell cycle PMID:23695676
enablesGO:0071889 14-3-3 protein binding with PR:P61981 hYWHAG PMID:23695676
PR:P53350 hPLK1 acts_upstream_of_or_withinGO:0008608 attachment of spindle microtubules to kinetochore PMID:17376779
NOT GO:0031577 spindle checkpoint signaling PMID:16760428
GO:0034092 negative regulation of maintenance of sister chromatid cohesion PMID:16580887
NOT GO:0034501 protein localization to kinetochore PMID:16760428
NOT GO:0034501 protein localization to kinetochore PMID:16760428
NOT GO:0034501 protein localization to kinetochore PMID:16760428
GO:0051310 metaphase chromosome alignment PMID:17376779
enablesGO:0004672 protein kinase activity PMID:16760428
GO:0005515 protein binding with PR:O43683 BUB1 BioGRID:BG-338598
GO:0005515 protein binding with PR:O60566 BUB1B BioGRID:BG-338598
GO:0005515 protein binding with PR:Q5FBB7 hSGO1 BioGRID:BG-338598
GO:0005515 protein binding BioGRID:BG-338598
located_inGO:0000776 kinetochore PMID:20624902
GO:0000922 spindle pole PMID:20823832
GO:0000940 outer kinetochore PMID:16760428
GO:0005813 centrosome PMID:16760428