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Protein Ontology report - phosphatidylinositol 3-kinase regulatory subunit alpha
PR:000012724 - http://purl.obolibrary.org/obo/PR_000012724
 
  Protein Forms  Complex      
Ontology Information Show OBO stanza
  PRO ID
PR:000012724   
  PRO namephosphatidylinositol 3-kinase regulatory subunit alpha 
  Synonyms
PRO-Short-label: EXACT:PIK3R1
Gene-based: RELATED:GRB1
Other: EXACT:phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha | PI3-kinase regulatory subunit alpha | PI3-kinase subunit p85-alpha | PI3K regulatory subunit alpha | PtdIns-3-kinase regulatory subunit alpha | PtdIns-3-kinase regulatory subunit p85-alpha
  Definition"A protein that is a translation product of the human PIK3R1 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 17                                        
         Modification0                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2503
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000012724
phosphatidylinositol 3-kinase regulatory subunit alpha
PIK3R1
"A protein that is a translation product of the human PIK3R1 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P26450
phosphatidylinositol 3-kinase regulatory subunit alpha (mouse)
mPIK3R1
"A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of mouse." [OMA:P26450, PRO:DNx]

organism-sequence


PR:P26450-1
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (mouse)
mPIK3R1/iso:1
"A phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-gene


PR:P27986
phosphatidylinositol 3-kinase regulatory subunit alpha (human)
hPIK3R1
"A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:000060710
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant K379E (human)
hPIK3R1/var:K379E
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Glu residue at the position equivalent to Lys-379 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Lys-379, CHEBI:29972." [PRO:DNx, Reactome:R-HSA-8944148]

organism-sequence


PR:000061166
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant R574I (human)
hPIK3R1/var:R574I
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has an Ile residue at the position equivalent to Arg-574 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Arg-574, CHEBI:30009." [PRO:DNx, Reactome:R-HSA-2399536]

organism-sequence


PR:000061750
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant G376R (human)
hPIK3R1/var:G376R
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has an Arg residue at the position equivalent to Gly-376 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Gly-376, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-2399717]

organism-sequence


PR:000062211
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant D560Y (human)
hPIK3R1/var:D560Y
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Tyr residue at the position equivalent to Asp-560 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asp-560, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-2399421]

organism-sequence


PR:000062219
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant R574T (human)
hPIK3R1/var:R574T
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Thr residue at the position equivalent to Arg-574 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Arg-574, CHEBI:30013." [PRO:DNx, Reactome:R-HSA-2399540]

organism-sequence


PR:000063145
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant D560H (human)
hPIK3R1/var:D560H
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a His residue at the position equivalent to Asp-560 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asp-560, CHEBI:29979." [PRO:DNx, Reactome:R-HSA-2399432]

organism-sequence


PR:000064239
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant N564D (human)
hPIK3R1/var:N564D
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has an Asp residue at the position equivalent to Asn-564 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asn-564, CHEBI:29958." [PRO:DNx, Reactome:R-HSA-2399427]

organism-sequence


PR:000064611
phosphatidylinositol 3-kinase regulatory subunit alpha sequence variant N564K (human)
hPIK3R1/var:N564K
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has a Lys residue at the position equivalent to Asn-564 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Asn-564, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-2399431]

organism-sequence


PR:P27986-1
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (human)
hPIK3R1/iso:1
"A phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 that is encoded in the genome of human." [PRO:DNx]

organism-sequence


PR:P27986-2
phosphatidylinositol 3-kinase regulatory subunit alpha isoform h2 (human)
hPIK3R1/iso:h2
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-2." [PRO:DNx, UniProtKB:P27986]

organism-sequence


PR:P27986-3
phosphatidylinositol 3-kinase regulatory subunit alpha isoform h3 (human)
hPIK3R1/iso:h3
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-3." [PRO:DNx, UniProtKB:P27986]

organism-sequence


PR:P27986-4
phosphatidylinositol 3-kinase regulatory subunit alpha isoform h4 (human)
hPIK3R1/iso:h4
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-4." [PRO:DNx, UniProtKB:P27986]

organism-sequence


PR:P27986-5
phosphatidylinositol 3-kinase regulatory subunit alpha isoform h5 (human)
hPIK3R1/iso:h5
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-5." [PRO:DNx, UniProtKB:P27986]

organism-modification


PR:000045733
phosphatidylinositol 3-kinase regulatory subunit alpha phosphorylated 1 (human)
hPIK3R1/Phos:1
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has been phosphorylated on the residue at the position equivalent to Tyr-688 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Tyr-688, MOD:00048." [iPTMnet:P27986, PMID:11337495]

organism-modification


PR:000048770
phosphatidylinositol 3-kinase regulatory subunit alpha ubiquitinated form (human)
hPIK3R1/UbiqLys+
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P27986, MOD:01148." [PRO:DNx, Reactome:R-HSA-3080572]

organism-modification


PR:000063059
phosphatidylinositol 3-kinase regulatory subunit alpha phosphotyrosine form (human)
hPIK3R1/PhosTyr+
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that includes at least one phosphorylated tyrosine. UniProtKB:P27986, MOD:00048." [PRO:DNx, Reactome:R-HSA-9680647]

organism-modification


PR:000066843
phosphatidylinositol 3-kinase regulatory subunit alpha deaminated 1 (human)
hPIK3R1/Deam:1
"A phosphatidylinositol 3-kinase regulatory subunit alpha (human) that has been deaminated on the residue at the position equivalent to Gln-415 of the amino acid sequence represented by UniProtKB:P27986-1. Example: UniProtKB:P27986-1, Gln-415, MOD:00685." [IEDB_epitope:2138801, PRO:DNx]

organism-gene


PR:Q63787
phosphatidylinositol 3-kinase regulatory subunit alpha (rat)
rPIK3R1
"A phosphatidylinositol 3-kinase regulatory subunit alpha that is encoded in the genome of rat." [OMA:Q63787, PRO:DNx]

organism-sequence


PR:Q63787-1
phosphatidylinositol 3-kinase regulatory subunit alpha isoform rp85-alpha (rat)
rPIK3R1/iso:rp85-alpha
"A phosphatidylinositol 3-kinase regulatory subunit alpha (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63787-1." [PRO:DNx, UniProtKB:Q63787]

organism-sequence


PR:Q63787-2
phosphatidylinositol 3-kinase regulatory subunit alpha isoform rp55-alpha (rat)
rPIK3R1/iso:rp55-alpha
"A phosphatidylinositol 3-kinase regulatory subunit alpha (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63787-2." [PRO:DNx, UniProtKB:Q63787]

organism-sequence


PR:Q63787-3
phosphatidylinositol 3-kinase regulatory subunit alpha isoform rp50-alpha (rat)
rPIK3R1/iso:rp50-alpha
"A phosphatidylinositol 3-kinase regulatory subunit alpha (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63787-3." [PRO:DNx, UniProtKB:Q63787]

sequence


PR:000039182
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
PIK3R1/iso:1
"A phosphatidylinositol 3-kinase regulatory subunit alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27986-1 or a 1:1 ortholog thereof." [PRO:DNx]

organism-sequence


PR:P26450-1
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (mouse)
mPIK3R1/iso:1
"A phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 that is encoded in the genome of mouse." [PRO:DNx]

organism-sequence


PR:P27986-1
phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 (human)
hPIK3R1/iso:1
"A phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 that is encoded in the genome of human." [PRO:DNx]

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PIK3R1 forms found in complexes   

PIK3R1 Component
 Complexes
PR:P27986 hPIK3R1 PR:000028429 GPIb-IX-V:vWF:14-3-3-zeta:p85 (human)