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Protein Ontology report - profilin-2
PR:000012586 - http://purl.obolibrary.org/obo/PR_000012586
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000012586   
  PRO nameprofilin-2 
  Synonyms
PRO-Short-label: EXACT:PFN2
Other: EXACT:profilin II
  Definition"A profilin that is a translation product of the human PFN2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000050050 profilin
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 7                                        
         Modification1                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000012586

profilin-2

PFN2


"A profilin that is a translation product of the human PFN2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P35080

profilin-2 (human)

hPFN2


"A profilin-2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P35080]


organism-sequence



PR:P35080-1

profilin-2 isoform 1 (human)

hPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-sequence



PR:P35080-2

profilin-2 isoform 2 (human)

hPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-gene



PR:Q9EPC6

profilin-2 (rat)

rPFN2


"A profilin-2 that is encoded in the genome of rat." [OMA:Q9EPC6, PRO:DNx]


organism-sequence



PR:Q9EPC6-1

profilin-2 isoform IIa (rat)

rPFN2/iso:IIa


"A profilin-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EPC6-1." [PRO:DNx, UniProtKB:Q9EPC6]


organism-sequence



PR:Q9EPC6-2

profilin-2 isoform IIb (rat)

rPFN2/iso:IIb


"A profilin-2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EPC6-2." [PRO:DNx, UniProtKB:Q9EPC6]


organism-gene



PR:Q9JJV2

profilin-2 (mouse)

mPFN2


"A profilin-2 that is encoded in the genome of mouse." [OMA:Q9JJV2, PRO:DNx]


organism-sequence



PR:Q9JJV2-1

profilin-2 isoform 1 (mouse)

mPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]

Yes

organism-sequence



PR:Q9JJV2-2

profilin-2 isoform 2 (mouse)

mPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]


organism-sequence



PR:Q9JJV2-3

profilin-2 isoform m3 (mouse)

mPFN2/iso:m3


"A profilin-2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV2-3." [PRO:DNx, UniProtKB:Q9JJV2]


sequence



PR:000037455

profilin-2 isoform 1

PFN2/iso:1


"A profilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV2-1 or a 1:1 ortholog thereof." [PMID:11034907, PRO:HJD]


organism-sequence



PR:P35080-1

profilin-2 isoform 1 (human)

hPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-sequence



PR:Q9JJV2-1

profilin-2 isoform 1 (mouse)

mPFN2/iso:1


"A profilin-2 isoform 1 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]

Yes

sequence



PR:000037456

profilin-2 isoform 2

PFN2/iso:2


"A profilin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJV2-2 or a 1:1 ortholog thereof." [PMID:11034907, PRO:HJD]


organism-sequence



PR:P35080-2

profilin-2 isoform 2 (human)

hPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35080]


organism-sequence



PR:Q9JJV2-2

profilin-2 isoform 2 (mouse)

mPFN2/iso:2


"A profilin-2 isoform 2 that is encoded in the genome of mouse." [PMID:11034907, PRO:HJD]


modification



PR:000020938

profilin-2, initiator methionine removed form

PFN2/InitMet-


"A profilin-2 that has had the initiator methionine removed." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q9JJV2-1 mPFN2/iso:1 acts_upstream_of_or_withinGO:0030837 negative regulation of actin filament polymerization MGI_ref:4844066; PMID:18001770
located_inGO:0043195 terminal bouton MGI_ref:3714870; PMID:17541406