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Protein Ontology report - proprotein convertase subtilisin/kexin type 9
PR:000012440 - http://purl.obolibrary.org/obo/PR_000012440
 
  Protein Forms      
Ontology Information Show OBO stanza
  PRO ID
PR:000012440   
  PRO nameproprotein convertase subtilisin/kexin type 9 
  Synonyms
PRO-Short-label: EXACT:PCSK9
Gene-based: RELATED:NARC1 | PSEC0052
Other: EXACT:NARC-1 | neural apoptosis-regulated convertase 1 | PC9 | proprotein convertase 9 | subtilisin/kexin-like protease PC9
  Definition"A protein that is a translation product of the human PCSK9 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence0                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2388
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000012440
proprotein convertase subtilisin/kexin type 9
PCSK9
"A protein that is a translation product of the human PCSK9 gene or a 1:1 ortholog thereof." [PRO:DNx]

organism-gene


PR:P59996
proprotein convertase subtilisin/kexin type 9 (rat)
rPCSK9
"A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of rat." [OMA:P59996, PRO:DNx]

organism-gene


PR:Q80W65
proprotein convertase subtilisin/kexin type 9 (mouse)
mPCSK9
"A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of mouse." [OMA:Q80W65, PRO:DNx]

organism-gene


PR:Q8NBP7
proprotein convertase subtilisin/kexin type 9 (human)
hPCSK9
"A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8NBP7]

organism-sequence


PR:Q8NBP7-1
proprotein convertase subtilisin/kexin type 9 isoform h1 (human)
hPCSK9/iso:h1
"A proprotein convertase subtilisin/kexin type 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NBP7-1." [PRO:DNx, UniProtKB:Q8NBP7]

organism-sequence


PR:Q8NBP7-2
proprotein convertase subtilisin/kexin type 9 isoform h2 (human)
hPCSK9/iso:h2
"A proprotein convertase subtilisin/kexin type 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NBP7-2." [PRO:DNx, UniProtKB:Q8NBP7]

organism-modification


PR:000050078
proprotein convertase subtilisin/kexin type 9 propeptide (human)
hPCSK9/propeptide
"A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide removed and that corresponds to the N-terminal portion after auto-proteolysis. Example: UniProtKB:Q8NBP7-1, 31-152." [PRO:DAN, UniProtKB:Q8NBP7]

organism-modification


PR:000050079
proprotein convertase subtilisin/kexin type 9, mature form (human)
hPCSK9/mature
"A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:Q8NBP7-1, 153-692." [PRO:DNx, UniProtKB:Q8NBP7]

organism-modification


PR:000082745
proprotein convertase subtilisin/kexin type 9, mature phosphorylated form (human)
hPCSK9/mature/PhosRes+
"A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. Example: UniProtKB:Q8NBP7-1, 153-692, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956943]

organism-modification


PR:000082745
proprotein convertase subtilisin/kexin type 9, mature phosphorylated form (human)
hPCSK9/mature/PhosRes+
"A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. Example: UniProtKB:Q8NBP7-1, 153-692, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956943]

modification


PR:000020891
proprotein convertase subtilisin/kexin type 9, signal peptide removed form
PCSK9/SigPep-
"A proprotein convertase subtilisin/kexin type 9 that has had the signal peptide removed." [PRO:DNx]

organism-modification


PR:000050078
proprotein convertase subtilisin/kexin type 9 propeptide (human)
hPCSK9/propeptide
"A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide removed and that corresponds to the N-terminal portion after auto-proteolysis. Example: UniProtKB:Q8NBP7-1, 31-152." [PRO:DAN, UniProtKB:Q8NBP7]

organism-modification


PR:000050079
proprotein convertase subtilisin/kexin type 9, mature form (human)
hPCSK9/mature
"A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide and propeptide removed. Example: UniProtKB:Q8NBP7-1, 153-692." [PRO:DNx, UniProtKB:Q8NBP7]

organism-modification


PR:000082745
proprotein convertase subtilisin/kexin type 9, mature phosphorylated form (human)
hPCSK9/mature/PhosRes+
"A proprotein convertase subtilisin/kexin type 9 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. Example: UniProtKB:Q8NBP7-1, 153-692, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956943]

modification


PR:000020892
proprotein convertase subtilisin/kexin type 9 proteolytic cleavage product
PCSK9/ClvPrd
"A proprotein convertase subtilisin/kexin type 9 that has been processed by proteolytic cleavage." [PRO:DNx]