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Protein Ontology report - proprotein convertase subtilisin/kexin type 5
PR:000012437 - http://purl.obolibrary.org/obo/PR_000012437
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000012437   
  PRO nameproprotein convertase subtilisin/kexin type 5 
  Synonyms
PRO-Short-label: EXACT:PCSK5
Gene-based: RELATED:PC5 | PC6
Other: EXACT:proprotein convertase 5 | proprotein convertase 6 | SPC6 | subtilisin-like proprotein convertase 6 | subtilisin/kexin-like protease PC5
  Definition"A subtilisin/kexin-type proprotein convertase that is a translation product of the human PCSK5 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000003136 subtilisin/kexin-type proprotein convertase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence0                                                  Organism-Sequence 8                                        
         Modification2                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2385
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000012437

proprotein convertase subtilisin/kexin type 5

PCSK5


"A subtilisin/kexin-type proprotein convertase that is a translation product of the human PCSK5 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P30432

furin-like protease 2 (fruit fly)

fly-PCSK5


"A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of fruit fly." [PRO:DNx]


organism-sequence



PR:P30432-1

furin-like protease 2 isoform D (fruit fly)

fly-PCSK5/iso:D


"A furin-like protease 2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30432-1." [PRO:DNx, UniProtKB:P30432]


organism-sequence



PR:P30432-2

furin-like protease 2 isoform A (fruit fly)

fly-PCSK5/iso:A


"A furin-like protease 2 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P30432-2." [PRO:DNx, UniProtKB:P30432]


organism-gene



PR:P41413

proprotein convertase subtilisin/kexin type 5 (rat)

rPCSK5


"A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of rat." [OMA:P41413, PRO:DNx]


organism-sequence



PR:P41413-1

proprotein convertase subtilisin/kexin type 5 isoform rPC5B (rat)

rPCSK5/iso:rPC5B


"A proprotein convertase subtilisin/kexin type 5 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41413-1." [PRO:DNx, UniProtKB:P41413]


organism-sequence



PR:P41413-2

proprotein convertase subtilisin/kexin type 5 isoform rPC5A (rat)

rPCSK5/iso:rPC5A


"A proprotein convertase subtilisin/kexin type 5 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41413-2." [PRO:DNx, UniProtKB:P41413]


organism-gene



PR:Q04592

proprotein convertase subtilisin/kexin type 5 (mouse)

mPCSK5


"A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of mouse." [OMA:Q04592, PRO:DNx]


organism-sequence



PR:Q04592-1

proprotein convertase subtilisin/kexin type 5 isoform PC5B (mouse)

mPCSK5/iso:PC5B


"A proprotein convertase subtilisin/kexin type 5 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04592-1." [PMID:8335106, PRO:HJD, UniProtKB:Q04592]

Yes

organism-sequence



PR:Q04592-2

proprotein convertase subtilisin/kexin type 5 isoform PC5A (mouse)

mPCSK5/iso:PC5A


"A proprotein convertase subtilisin/kexin type 5 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q04592-2." [PMID:8468318, PRO:HJD, UniProtKB:Q04592]

Yes

organism-gene



PR:Q92824

proprotein convertase subtilisin/kexin type 5 (human)

hPCSK5


"A proprotein convertase subtilisin/kexin type 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q92824]


organism-sequence



PR:Q92824-1

proprotein convertase subtilisin/kexin type 5 isoform hPC6B (human)

hPCSK5/iso:hPC6B


"A proprotein convertase subtilisin/kexin type 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92824-1." [PRO:DNx, UniProtKB:Q92824]


organism-sequence



PR:Q92824-2

proprotein convertase subtilisin/kexin type 5 isoform hPC6A (human)

hPCSK5/iso:hPC6A


"A proprotein convertase subtilisin/kexin type 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92824-2." [PRO:DNx, UniProtKB:Q92824]


modification



PR:000020887

proprotein convertase subtilisin/kexin type 5, signal peptide removed form

PCSK5/SigPep-


"A proprotein convertase subtilisin/kexin type 5 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000020888

proprotein convertase subtilisin/kexin type 5 proteolytic cleavage product

PCSK5/ClvPrd


"A proprotein convertase subtilisin/kexin type 5 that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q04592-1 mPCSK5/iso:PC5B located_inGO:0005794 Golgi apparatus MGI_ref:84424; PMID:8947550
PR:Q04592-2 mPCSK5/iso:PC5A located_inGO:0030141 secretory granule MGI_ref:84424; PMID:8947550