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Protein Ontology report - nuclear factor of activated T-cells, cytoplasmic 2
PR:000011164 - http://purl.obolibrary.org/obo/PR_000011164
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000011164   
  PRO namenuclear factor of activated T-cells, cytoplasmic 2 
  Synonyms
PRO-Short-label: EXACT:NFATC2
Gene-based: RELATED:NFAT1 | NFATP
Other: EXACT:NF-ATc2 | NF-ATp | NFAT pre-existing subunit | NFATc2 | T-cell transcription factor NFAT1
  Definition"A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence0                                                  Organism-Sequence 9                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000011164

nuclear factor of activated T-cells, cytoplasmic 2

NFATC2


"A protein that is a translation product of the human NFATC2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q13469

nuclear factor of activated T-cells, cytoplasmic 2 (human)

hNFATC2


"A nuclear factor of activated T-cells, cytoplasmic 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13469]


organism-sequence



PR:Q13469-1

nuclear factor of activated T-cells, cytoplasmic 2 isoform h1 (human)

hNFATC2/iso:h1


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13469-1." [PRO:DNx, UniProtKB:Q13469]


organism-sequence



PR:Q13469-2

nuclear factor of activated T-cells, cytoplasmic 2 isoform h2 (human)

hNFATC2/iso:h2


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13469-2." [PRO:DNx, UniProtKB:Q13469]


organism-sequence



PR:Q13469-3

nuclear factor of activated T-cells, cytoplasmic 2 isoform h3 (human)

hNFATC2/iso:h3


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13469-3." [PRO:DNx, UniProtKB:Q13469]


organism-sequence



PR:Q13469-4

nuclear factor of activated T-cells, cytoplasmic 2 isoform h4 (human)

hNFATC2/iso:h4


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13469-4." [PRO:DNx, UniProtKB:Q13469]


organism-sequence



PR:Q13469-5

nuclear factor of activated T-cells, cytoplasmic 2 isoform h5 (human)

hNFATC2/iso:h5


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13469-5." [PRO:DNx, UniProtKB:Q13469]


organism-modification



PR:000048590

nuclear factor of activated T-cells, cytoplasmic 2 phosphorylated 1 (human)

hNFATC2/Phos:1


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that has been post-translationally modified to include phosphoserine at positions 171, 172, 174, 175, 177, 213, 217, 221, 243, 268, 274, 276, 280 and 326 of the amino acid sequence represented by UniProtKB:Q13469. UniProtKB:Q13469, Ser-171/Ser-172/Ser-174/Ser-175/Ser-177/Ser-213/Ser-217/Ser-221/Ser-243/Ser-268/Ser-274/Ser-276/Ser-280/Ser-326, MOD:00046." [PRO:DNx, Reactome:R-HSA-2025848]


organism-modification



PR:000048591

nuclear factor of activated T-cells, cytoplasmic 2 phosphorylated 2 (human)

hNFATC2/Phos:2


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-243 of the amino acid sequence represented by UniProtKB:Q13469. UniProtKB:Q13469, Ser-243, MOD:00046." [PRO:DNx, Reactome:R-HSA-2025894, Reactome:R-HSA-2685626]


organism-modification



PR:000069052

nuclear factor of activated T-cells, cytoplasmic 2 deaminated 1 (human)

hNFATC2/Deam:1


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that has been deaminated on the residue at the position equivalent to Gln-444 of the amino acid sequence represented by UniProtKB:Q13469-1. Example: UniProtKB:Q13469-1, Gln-444, MOD:00685." [IEDB_epitope:1375721, PRO:DNx]


organism-modification



PR:000070859

nuclear factor of activated T-cells, cytoplasmic 2 phosphorylated 3 (human)

hNFATC2/Phos:3


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-73 of the amino acid sequence represented by UniProtKB:Q13469-1. Example: UniProtKB:Q13469-1, Ser-73, MOD:00046." [IEDB_epitope:609459, PRO:DNx]


organism-modification



PR:000071835

nuclear factor of activated T-cells, cytoplasmic 2 methylated 1 (human)

hNFATC2/Me:1


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that has been methylated on the residue at the position equivalent to Cys-588 of the amino acid sequence represented by UniProtKB:Q13469-1. Example: UniProtKB:Q13469-1, Cys-588, MOD:00660." [IEDB_epitope:1044602, PRO:DNx]


organism-modification



PR:000075392

nuclear factor of activated T-cells, cytoplasmic 2 cysteinylated 1 (human)

hNFATC2/Cyst:1


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-515 of the amino acid sequence represented by UniProtKB:Q13469-1. Example: UniProtKB:Q13469-1, Cys-515, MOD:00765." [IEDB_epitope:882352, PRO:DNx]


organism-modification



PR:000081282

nuclear factor of activated T-cells, cytoplasmic 2 methylated 2 (human)

hNFATC2/Me:2


"A nuclear factor of activated T-cells, cytoplasmic 2 (human) that has been methylated on the residue at the position equivalent to Cys-720 of the amino acid sequence represented by UniProtKB:Q13469-1. Example: UniProtKB:Q13469-1, Cys-720, MOD:00660." [IEDB_epitope:998951, PRO:DNx]


organism-gene



PR:Q60591

nuclear factor of activated T-cells, cytoplasmic 2 (mouse)

mNFATC2


"A nuclear factor of activated T-cells, cytoplasmic 2 that is encoded in the genome of mouse." [OMA:Q60591, PRO:DNx]


organism-sequence



PR:Q60591-1

nuclear factor of activated T-cells, cytoplasmic 2 isoform 1 (mouse)

mNFATC2/iso:1


"A nuclear factor of activated T-cells, cytoplasmic 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60591-1." [PMID:8235597, PMID:8668213, PRO:KRC, UniProtKB:Q60591-1]


organism-sequence



PR:Q60591-2

nuclear factor of activated T-cells, cytoplasmic 2 isoform 2 (mouse)

mNFATC2/iso:2


"A nuclear factor of activated T-cells, cytoplasmic 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60591-2." [PMID:8668213, PRO:KRC, UniProtKB:Q60591]

Yes

organism-sequence



PR:Q60591-3

nuclear factor of activated T-cells, cytoplasmic 2 isoform 3 (mouse)

mNFATC2/iso:3


"A nuclear factor of activated T-cells, cytoplasmic 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60591-3." [PMID:8668213, PRO:KRC, UniProtKB:Q60591]

Yes

organism-sequence



PR:Q60591-4

nuclear factor of activated T-cells, cytoplasmic 2 isoform 4 (mouse)

mNFATC2/iso:4


"A nuclear factor of activated T-cells, cytoplasmic 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q60591-4." [PMID:11278367, PRO:KRC]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q60591-2 mNFATC2/iso:2 acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:81049; PMID:8668213
PR:Q60591-3 mNFATC2/iso:3 acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:81049; PMID:8668213
PR:Q60591-4 mNFATC2/iso:4 acts_upstream_of_or_withinGO:0045944 positive regulation of transcription by RNA polymerase II MGI_ref:2684708; PMID:11278367
enablesGO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding MGI_ref:2684708; PMID:11278367