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Protein Ontology report - endonuclease 8-like 2
PR:000011123 - http://purl.obolibrary.org/obo/PR_000011123
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000011123   
  PRO nameendonuclease 8-like 2 
  Synonyms
PRO-Short-label: EXACT:NEIL2
Gene-based: RELATED:Gm1212
Other: EXACT:DNA glycosylase/AP lyase Neil2 | DNA-(apurinic or apyrimidinic site) lyase Neil2 | endonuclease VIII-like 2 | NEH2 | Nei homolog 2 | Nei-like protein 2
  Definition"A protein that is a translation product of the human NEIL2 gene or a 1:1 ortholog thereof." [PRO:DNx] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000011123

endonuclease 8-like 2

NEIL2


"A protein that is a translation product of the human NEIL2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q6R2P8

endonuclease 8-like 2 (mouse)

mNEIL2


"An endonuclease 8-like 2 that is encoded in the genome of mouse." [OMA:Q6R2P8, PRO:DNx]


organism-gene



PR:Q969S2

endonuclease 8-like 2 (human)

hNEIL2


"An endonuclease 8-like 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q969S2]


organism-sequence



PR:Q969S2-1

endonuclease 8-like 2 isoform 1 (human)

hNEIL2/iso:1


"An endonuclease 8-like 2 isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028592

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)

hNEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]

Yes

organism-modification



PR:000045372

endonuclease 8-like 2 isoform 1 unacetylated 1 (human)

hNEIL2/iso:1/UnAc:1


"An endonuclease 8-like 2 isoform 1 (human) that lacks acetylation on Lys-50 and Lys-154. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291." [PMID:15175427, PRO:CNA]

Yes

organism-sequence



PR:Q969S2-2

endonuclease 8-like 2 isoform h2 (human)

hNEIL2/iso:h2


"An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-2." [PRO:DNx, UniProtKB:Q969S2]


organism-sequence



PR:Q969S2-3

endonuclease 8-like 2 isoform h3 (human)

hNEIL2/iso:h3


"An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-3." [PRO:DNx, UniProtKB:Q969S2]


organism-sequence



PR:Q969S2-4

endonuclease 8-like 2 isoform h4 (human)

hNEIL2/iso:h4


"An endonuclease 8-like 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-4." [PRO:DNx, UniProtKB:Q969S2]


organism-modification



PR:000048574

endonuclease 8-like 2, initiator methionine removed form (human)

hNEIL2/InitMet-


"An endonuclease 8-like 2 (human) that has had the initiator methionine removed. UniProtKB:Q969S2, 2-332." [PRO:DNx, Reactome:R-HSA-5649650]


organism-modification



PR:000028592

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)

hNEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]

Yes

sequence



PR:000028589

endonuclease 8-like 2 isoform 1

NEIL2/iso:1


"An endonuclease 8-like 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q969S2-1 or a 1:1 ortholog thereof." [PMID:15175427, PRO:PD]


organism-sequence



PR:Q969S2-1

endonuclease 8-like 2 isoform 1 (human)

hNEIL2/iso:1


"An endonuclease 8-like 2 isoform 1 that is encoded in the genome of human." [PRO:PD]


organism-modification



PR:000028592

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)

hNEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]

Yes

organism-modification



PR:000045372

endonuclease 8-like 2 isoform 1 unacetylated 1 (human)

hNEIL2/iso:1/UnAc:1


"An endonuclease 8-like 2 isoform 1 (human) that lacks acetylation on Lys-50 and Lys-154. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291." [PMID:15175427, PRO:CNA]

Yes

modification



PR:000028590

endonuclease 8-like 2 isoform 1, initiator methionine removed form

NEIL2/iso:1/InitMet-


"An endonuclease 8-like 2 isoform 1 that has had the initiator methionine removed." [PMID:12097317, PRO:CNA]


modification



PR:000028591

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1

NEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed form that is acetylated. Example: UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]


organism-modification



PR:000028592

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)

hNEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]

Yes

modification



PR:000020726

endonuclease 8-like 2, initiator methionine removed form

NEIL2/InitMet-


"An endonuclease 8-like 2 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000028590

endonuclease 8-like 2 isoform 1, initiator methionine removed form

NEIL2/iso:1/InitMet-


"An endonuclease 8-like 2 isoform 1 that has had the initiator methionine removed." [PMID:12097317, PRO:CNA]


modification



PR:000028591

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1

NEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed form that is acetylated. Example: UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]


organism-modification



PR:000028592

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)

hNEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]

Yes

organism-modification



PR:000048574

endonuclease 8-like 2, initiator methionine removed form (human)

hNEIL2/InitMet-


"An endonuclease 8-like 2 (human) that has had the initiator methionine removed. UniProtKB:Q969S2, 2-332." [PRO:DNx, Reactome:R-HSA-5649650]


organism-modification



PR:000028592

endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 (human)

hNEIL2/iso:1/InitMet-/Ac:1


"An endonuclease 8-like 2 isoform 1, initiator methionine removed acetylated 1 in human. UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064." [KAT:Q969S2, PMID:15175427, PRO:PD]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000028592 hNEIL2/iso:1/InitMet-/Ac:1
UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, MOD:00064
enablesdecreased GO:0019104 DNA N-glycosylase activity relative to PR:000045372 endonuclease 8-like 2 isoform 1 unmodified form (human) PMID:15175427
PR:000045372 hNEIL2/iso:1/UnAc:1
UniProtKB:Q969S2-1, 2-331, Lys-50/Lys-154, PR:000026291
enablesGO:0019104 DNA N-glycosylase activity PMID:15175427